A5018898871- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Advanced X-ray and CT Imaging
- Congenital heart defects research
- Radiation Dose and Imaging
- Coronary Artery Anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Congenital Diaphragmatic Hernia Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular and Diving-Related Complications
- Vascular anomalies and interventions
- Acute Kidney Injury Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
University of Bayreuth
2025
German Center for Lung Research
2024
Deutsches Herzzentrum München
1996-2021
German Cardiac Society
2020
Helen DeVos Children's Hospital
2018
Corewell Health Blodgett Hospital
2018
Spectrum Health
2018
Westpfalz Klinikum
2017
OBJECTIVE: Assessment of right ventricular volume and mass with three dimensional echocardiography comparison magnetic resonance imaging. METHODS: Measurements volumes performed on datasets acquired by transthoracic were compared to those obtained from imaging the same day. Volumes measured in end systole diastole ejection fraction calculated. Right was assessed systole. With both methods, areas a 2 mm thick slice ventricle manually outlined multiplied thickness obtain volume. Slice number...
The impact of an atrial septal defect in the elderly with reduced diastolic elasticity left ventricle is unclear. We studied hemodynamic changes during balloon occlusion defects patients over 60 years age. In 18 (61-78 old; median, 70), pressure and mitral valve inflow was measured complete after deflation balloon. seven patients, E/A ratio increased markedly (P = 0.02). Mean pressures reached values 27 mm Hg v-wave peak 55 Hg. Two received a transcatheter device closure developed congestive...
Abstract Objectives To analyze risk factors for chylothorax in infants after congenital heart surgery and the efficacy of median chain triglyceride diet (MCT). develop our therapeutic pathway management chylothorax. Patients methods Retrospective review institutional surgical database patient charts including detailed perioperative informations between 1/2000 10/2006. Data analyzing with an elimination regression analysis. Results Twenty six out 282 patients had (=9.2%). Secondary chest...
The longevity of valved right ventricle to pulmonary artery (RV-PA) conduits is limited due calcification and degeneration non-viable structures. Xenografts are commonly used because the restricted availability cryopreserved homografts. Tissue-engineered (de-cellularised) valves (TEPVs) were thought be a valuable alternative homografts postoperative seeding with viable autologous vascular endothelial cells.From July 2007 December 2008, xenogenous TEPV (Matrix P plus) implanted in 16 patients...
Modern fluoroscopic angiography systems permit rendering of three-dimensional volumetric data sets using rotational (3D-RA). Along with magnetic resonance imaging (MRI) or multi-detector-row computed tomography (MDCT) sets, they can be fused live fluoroscopy images for roadmapping during therapeutic procedures, but the value multimodality has not been clarified.In a pediatric cardiac catheterization laboratory, we analyzed 78 interventional cardiovascular procedures in which 3D models 3D-RA,...
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and lymphocyte-to-monocyte (LMR) are emerging biomarkers for systemic inflammation have been shown to predict morbidity mortality several diseases. However, lack of pediatric reference intervals (RIs) prevents their comprehensive use in patient care medical research.We calculated corresponding confidence NLR, PLR, LMR from birth 18 years using a data-mining approach: We analyzed 232 746 blood counts 60 685 patients performed...
Cinematic rendering (CR) is based on a new algorithm that creates photo-realistic three-dimensional (3D) picture from cross-sectional images. Previous studies have shown its positive impact preoperative planning. To date, CR presentation has only been possible 2D screens which limited natural 3D perception. depict CR-hearts spatially, we used mixed-reality technology and mapped corresponding hearts as holograms in space. Our aim was to assess the benefits of CR-holograms planning cardiac...
Introduction: Pulmonary hypertension (PH) is a common complication in patients with congenital heart disease (CHD), aggravating the natural, post-operative, or post-interventional course of underlying anomaly. The various CHDs differ substantially characteristics, functionality, and clinical outcomes among each other compared diseases pulmonary hypertension. Objective: To describe current management strategies for adults PH relation to different types CHD based on real-world data. Methods...
Mutations in the human desmin gene cause myopathies and cardiomyopathies. This study aimed to elucidate molecular mechanisms initiated by heterozygous R406W-desmin mutation development of a severe early-onset cardiac phenotype.We report an adolescent patient who underwent transplantation as result restrictive cardiomyopathy caused mutation. Sections explanted heart were analyzed with antibodies specific 406W-desmin intercalated disc proteins. Effects R406W on properties addressed cell...
Numerous genetic studies have established a role for rare genomic variants in Congenital Heart Disease (CHD) at the copy number variation (CNV) and de novo variant (DNV) level. To identify novel haploinsufficient CHD disease genes, we performed an integrative analysis of CNVs DNVs identified probands with including cases sporadic thoracic aortic aneurysm. We assembled CNV data from 7,958 14,082 controls gene-wise burden deletions versus controls. In addition, rate testing 2,489...
Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports D-TGA patients with rare variants individual genes, majority cases remain genetically elusive. Familial recurrence patterns and observation that most sporadic suggest polygenic inheritance for disorder, yet this remains unexplored. Objective: We sought to study role common single nucleotide polymorphisms (SNPs)...
Nephropathy is known to occur in patients with long-standing cyanotic congenital heart disease (CCHD). In order assess the incidence, nature and degree of problem among such patients, discriminating urine analyses were performed 26 CCHD, a mean age 22 (10-42) y. Ten showed reduced glomerular function, six whom also had advanced glomerulopathy. Glomerular filtration rates below normal half occurred glomerular-type proteinuria five, tubular-type one without pathological four. An elevated...
QUESTIONS UNDER STUDY: To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for detection acute kidney injury in patients undergoing congenital heart surgery. METHODS: Serial samples NGAL were collected from 139 consecutive with defects aged 3 days to 30 years after admission intensive care unit, 2 6 hours end cardiopulmonary bypass. Biomarker levels compared perioperative data retrospectively. Acute was defined according...