A5057894973- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Genetic Syndromes and Imprinting
- Sports Performance and Training
- Diabetes Management and Research
- Pancreatic function and diabetes
- Pharmacology and Obesity Treatment
- Cardiovascular and exercise physiology
- Diabetes and associated disorders
- Thermoregulation and physiological responses
- Pancreatitis Pathology and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hormonal Regulation and Hypertension
Eli Lilly (United States)
2008-2025
Indiana University School of Medicine
2000-2024
Indiana University
2024
Indianapolis Zoo
2019-2024
Dialyse Centrum Groningen
2024
Foundation Medicine (United States)
2022
California State University, Fresno
2009
Sierra Engineering (United States)
2008
University of Virginia
1994-2003
Université Laval
1999-2003
Retatrutide (LY3437943) is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors. Its dose-response relationships with respect to side effects, safety, efficacy for treatment obesity are not known.We conducted a phase 2, double-blind, randomized, placebo-controlled trial involving adults who had body-mass index (BMI, weight in kilograms divided by square height meters) 30 or higher BMI 27 less than plus at least one weight-related...
Although the use of insulin tolerance test (ITT) for diagnosis adult GH deficiency is well established, diagnostic peak cut-points other commonly used stimulation tests are less clearly established. Despite that fact, majority patients in United States who evaluated do not undergo testing. The aim this study was to evaluate relative utility six different methods testing currently practice and develop each these tests. Thirty-nine (26 male, 13 female) with adult-onset hypothalamic-pituitary...
To determine the effect of tirzepatide, a dual agonist glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptors, on biomarkers nonalcoholic steatohepatitis (NASH) fibrosis in patients with type 2 diabetes mellitus (T2DM).Patients T2DM received either once weekly tirzepatide (1, 5, 10, or 15 mg), dulaglutide (1.5 placebo for 26 weeks. Changes from baseline alanine aminotransferase (ALT), aspartate (AST), keratin-18 (K-18), procollagen III (Pro-C3), adiponectin were...
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease associated with liver-related complications and death. The efficacy safety of tirzepatide, an agonist the glucose-dependent insulinotropic polypeptide glucagon-like peptide-1 receptors, in patients MASH moderate or severe fibrosis unclear.
Abstract Retatrutide is a novel triple agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon receptors. A 48-week phase 2 obesity study demonstrated weight reductions 22.8% 24.2% with retatrutide 8 12 mg, respectively. The primary objective this substudy was to assess mean relative change from baseline in liver fat (LF) at 24 weeks participants that metabolic dysfunction-associated steatotic disease ≥10% LF. Here, randomized, double-blind,...
ABSTRACT Background and Aims The performance of non‐invasive liver tests (NITs) is known to vary across settings subgroups. We systematically evaluated whether the three NITs in detecting advanced fibrosis patients with metabolic dysfunction‐associated steatotic disease (MASLD) varies age, sex, body mass index (BMI), type 2 diabetes mellitus (T2DM) status or enzymes. Methods Data from 586 adult LITMUS Metacohort participants histologically characterised MASLD were included. diagnostic...
Adult GH deficiency (GHD) is currently diagnosed in patients with either a history of childhood-onset GHD or acquired hypothalamic-pituitary disease by stimulation testing. However, tests are invasive, time consuming, and associated side effects. Based on preliminary analyses enrolled the U.S. Hypopituitary Control Complications Study (HypoCCS), we proposed presence adult could be predicted 95% accuracy three more pituitary hormone deficiencies (PHDs) serum IGF-I concentration less than 84...
Serum GH concentrations are increased in fasted or malnourished human subjects. We investigated the dynamic mechanisms underlying this phenomenon nine normal men by analyzing serum measured blood obtained at 5-min intervals over 24 h on a control (fed) day and second of fast with multiple-parameter deconvolution method to simultaneously resolve endogenous secretory clearance rates. Two days fasting induced 5-fold increase 24-h production rate [78 +/- 12 vs. 371 57 micrograms/Lv (Lv, liter...
In humans, serum growth hormone (GH) concentrations are significantly higher in women than men, but the neuroendocrine mechanisms that underlie such gender differences not known. We compared normal episodic GH secretion males and females three distinct settings: two human studies employing quite different assay techniques (immunoradiometric a high-sensitivity immunofluorimetric method) rat study. To quantify amount of regularity data, we utilized approximate entropy (ApEn), scale-...
Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence cardiovascular disease. The stimulatory effects on GH-insulin-like growth factor I (IGF-I) axis orally administered MK-677, a GH-releasing peptide mimetic, were investigated. Thirty-two healthy subjects (15 women 17 men, aged 64-81 yr) enrolled in randomized, double blind, placebo-controlled trial. They received placebo or 2, 10, 25 mg orally, once...
Both fasting and sleep increase the secretion of human GH and, therefore, might explain its predominantly nocturnal release. To study precise temporal relationship between secretory episodes cortical activity, measurements electroencephalogram stage recordings were performed every 30 s for 8 h in six young male volunteers fasted 24 h. was measured two drops whole blood, which directly sampled into assay tube using a continuous blood withdrawal pump fraction collector. Concomitant serum...
Pulses of growth hormone (GH) release in acromegaly may arise from hypothalamic regulation or random events intrinsic to adenomatous tissue. To distinguish between these possibilities, serum GH concentrations were measured at 5-min intervals for 24 h acromegalic men and women with active (n = 19) inactive 9) disease normal young adults the fed 20) fasted 16) states. Daily secretion rates, calculated by deconvolution analysis, greater patients than (P < 0.05) but not subjects. Significant...
Abstract CLASEY, JODY L., CLAUDE BOUCHARD, C. DAVID TEATES, JILL E. RIBLETT, MICHAEL O. THORNER, MARK L. HARTMAN, AND ARTHUR WELTMAN. the use of anthropometric and dual‐energy X‐ray absorptiometry (DXA) measures to estimate total abdominal visceral fat in men women. Obes Res . Objective : A single‐slice computed tomography (CT) scan provides a criterion measure (TAF) (AVF), but this procedure is often prohibitive due radiation exposure, cost, accessibility. In present study, utility...
Exercise of appropriate intensity is a potent stimulus for GH and cortisol secretion. Circadian diurnal rhythms may modulate the responses to exercise, but nutrition, sleep, prior exercise patterns, body composition are potentially confounding factors. To determine influence time day on response acute we studied 10 moderately trained young men (24.1 +/- 1.1 yr old; maximal oxygen consumption, 47.9 1.4 mL/kg.min; percent fat, 13.2 0.6%). After supervised night sleep standard meal 12 h before...
To determine if insulin-like growth factor I (IGF-I) inhibits pulsatile hormone (GH) secretion in man, recombinant human IGF-I (rhIGF-I) was infused for 6 h at 10 micrograms.kg-1.h-1 during a euglycemic clamp normal men who were fasted 32 to enhance GH secretion. Saline alone an otherwise identical second admission as control. As result of rhIGF-I infusion, total and free concentrations increased three- fourfold, respectively. Mean fell from 6.3 +/- 1.6 0.59 0.07 micrograms/liter after 120...
We investigated whether gender affects the physiological relationships between release of GH and age, body composition, levels physical fitness in humans. studied 32 eumenorrheic females (age = 31 +/- 5 yr) 12 males 27 yr). Significant differences were found for peak oxygen consumption [VO2 40.5 6.9 (females) vs. 50.1 11.6 (males) ml/kg.min-1, P < 0.05] composition [hydrostatic weighing, percentage fat 28.7 5.4 18.1 9.8 (males), but not mass index [BMI 23.7 3.1 24.0 3.3 (males)]. Blood...
To determine if the mode of 17 beta-estradiol (E2) administration affects growth hormone (GH) concentrations, eight postmenopausal women were studied under following conditions: (1) control (no E2), (2) oral E2 (Estrace, 1 mg every 12 h for 2 weeks) and (3) transdermal (Estraderm patch, 0.1 mg, two patches changed daily weeks). Blood was collected 5 min 24 assayed serum GH concentrations using a sensitive chemiluminescence assay. Serum levels comparable during both treatment regimens when...
Modifications were made to a commercially available human (h) GH chemiluminescence assay (Nichols Luma Tag hGH assay), which improved its sensitivity 0.002 micrograms/L. The results of this had high correlation with those the Nichols immunoradiometric (IRMA; r = 0.91; P < 0.001). addition recombinant hGH-binding protein (0.1-10 nmol/L) standards and serum samples caused dose-responsive reduction in measured both IRMA; at physiological concentrations protein, 10-20% was observed. Fifteen...
We investigated non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes (T1D), insulin-naïve insulin-treated 2 (T2D). Baseline data from who had fat content (LFC) evaluated by magnetic resonance imaging four phase 3 studies of basal insulin peglispro (BIL) were analysed. Associations NAFLD clinical characteristics, glycaemic control therapy evaluated. The (defined as LFC ≥ 6%) was low T1D (8.8%) but high T2D, greater (75.6%) vs...
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty (NAFLD), is the most common form of chronic disease. It exists either simple steatosis or its more progressive form, metabolic steatohepatitis (MASH), formerly, (NASH). The global prevalence MASLD estimated to be 32% among adults and projected continue rise with increasing rates obesity, type 2 diabetes, syndrome. While often considered benign reversible, MASH progressive, potentially...
To investigate the effects of exercise intensity on growth hormone (GH) release, 10 male subjects were tested 6 randomly ordered occasions [1 control condition (C), 5 conditions (Ex)]. Serum GH concentrations measured in samples obtained at 10-min intervals between 0700 and 0900 (baseline) 1300 (exercise+ recovery). Integrated (IGHC) calculated by trapezoidal reconstruction. During Ex exercised for 30 min (0900-0930) one following intensities [normalized to lactate threshold (LT)]: 25 75%...
Numerous physiological factors modulate GH secretion, but these variables are not independent of one another. We studied 40 younger (20–29 yr.; 21 men and 19 women) 62 older (57–80 35 27 adults to determine the contributions several demographic variability in integrated 24-h concentrations. Serum was measured every 10 min for 24 h an enhanced sensitivity chemiluminescence assay. The predictor included: age group (young or old), gender, abdominal visceral fat (by computed tomography), total...