A5015873957- Sepsis Diagnosis and Treatment
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Reproductive Health and Technologies
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Male Reproductive Health Studies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Advanced Materials and Mechanics
- Reproductive System and Pregnancy
- Neonatal and Maternal Infections
- Organ Transplantation Techniques and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Quantum, superfluid, helium dynamics
- Hemodynamic Monitoring and Therapy
- Urological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sexual function and dysfunction studies
Eli Lilly (United States)
2016-2025
University of Florida
2008-2024
Indianapolis Zoo
2024
Addenbrooke's Hospital
2022
University of Cambridge
2022
Fisher College
2022
Mannar Hospital
2021
Harvard University
1990-2017
University of Kansas Medical Center
2017
University of British Columbia
1999-2014
BACKGROUND: The objective of this prospective controlled trial was to investigate the ability a group serum and peritoneal fluid (PF) markers predict, non-surgically, endometriosis. METHODS AND RESULTS: Serum PF samples were obtained from 130 women while undergoing laparoscopy for pain, infertility, tubal ligation or sterilization reversal. Concentrations six cytokines [interleukin (IL)-1β, IL-6, IL-8, IL-12, IL-13 tumour necrosis factor (TNF)-α] measured in PF, reactive oxygen species (ROS)...
A molecular signature, derived from integrated analysis of clinical data, the metabolome, and proteome in prospective human studies, improved prediction death patients with sepsis, potentially identifying a subset who merit intensive treatment.
Metabolic acidosis and changes in serum osmolarity are consequences of 0.9% normal saline (NS) solution administration. We sought to determine if these physiologic influence patient outcome. Patients undergoing aortic reconstructive surgery were enrolled randomly assigned receive lactated Ringer's (LR) (n = 33) or NS a double-blinded fashion. Anesthetic fluid management standardized. Multiple measures outcome monitored. The patients developed hyperchloremic received more bicarbonate therapy...
The imbalance between reactive oxygen species (ROS) production and total antioxidant capacity (TAC) in seminal fluid indicates oxidative stress is correlated with male infertility. A composite ROS-TAC score may be more strongly infertility than ROS or TAC alone. We measured ROS, TAC, scores semen from 127 patients 24 healthy controls. Of the patients, 56 had varicocele, eight varicocele prostatitis, 35 vasectomy reversals, 28 idiopathic levels were higher among infertile men, especially...
Loss of muscle mass and strength are natural consequences the aging process, accompanied by an increased prevalence chronic health conditions. Research suggests that in elderly, presence comorbidities may impact mass/strength relationship. The objectives this study were to characterize relationship older adults USA examine a variety on Data obtained from National Health Nutrition Examination Survey 1999–2002 databases. Subjects aged 50 years included present study. Muscle was assessed...
In semen, granulocytes are major producers of reactive oxygen species (ROS), which can damage sperm. The diagnosis leukocytospermia is usually based on the World Health Organization (WHO) definition 1 x 10(6) white blood cells per milliliter, but controversy remains over minimum leukocyte level that impairs fertility. goals this study were to clarity relationship between count and oxidative stress establish associated with stress. To do so, we compared in semen samples different counts (by...
ABSTRACT: A total of 28 donor semen samples were used to evaluate the characteristics laboratory variability in measuring reactive oxygen species (ROS). The objectives this study assess interassay (same sample observed on different days by same observers) variability; interdonor, intraobserver (replications day) and interobserver (multiple observers day with sample) luminal‐dependent chemiluminescence assay establish an optimal age sperm concentration. Semen collected from 6 healthy donors...
No AccessJournal of UrologyClinical Urology: Original Articles1 Jul 1999EXCLUSION CRITERIA ENHANCE THE SPECIFICITY AND POSITIVE PREDICTIVE VALUE OF NMP22* BTA STAT [dagger] SHASHIKALA SHARMA, CRAIG D. ZIPPE, LAKSHMI PANDRANGI, DAVID NELSON, and ASHOK AGARWAL SHARMASHASHIKALA SHARMA , ZIPPECRAIG ZIPPE PANDRANGILAKSHMI PANDRANGI NELSONDAVID NELSON AGARWALASHOK View All Author Informationhttps://doi.org/10.1097/00005392-199907000-00014AboutFull TextPDF ToolsAdd to favoritesDownload...
Clinical trials with novel therapeutic agents for severe sepsis have suggested that patients might respond differently depending on causative microorganism. Data from a large, placebo-controlled trial of recombinant human drotrecogin alfa (activated) (DrotAA) were analyzed by type microorganism treatment-associated differences in mortality, coagulopathy, and inflammatory response. Compared placebo, mortality rates associated DrotAA consistently reduced each group (gram-positive bacteria,...
Acute kidney injury (AKI) is common in critically ill patients with severe sepsis (SS), and the predictors of AKI this population have not been well characterized. The study group was placebo Prospective Recombinant Human Activated Protein C Worldwide Evaluation Severe Sepsis (PROWESS) data set. PROWESS a prospective, randomized, controlled use drotrecogin alpha (activated) for treatment SS. Placebo who had an admission renal organ failure score 2 or more were excluded. defined as increase...
Objective: To generate and validate an initial version of the predisposition, insult/infection, response, organ dysfunction (PIRO) staging model for risk stratification in severe sepsis. The goal was to create distinct levels mortality within each four categories (P, I, R, O), that these would be meaningful terms prediction independent other categories. Design: Retrospective analysis using a statistical utilizing two large, global databases patients with Setting Patients: Database #1:...
Examine the association between obesity and glycemic control among patients with type 1 (T1DM) or 2 diabetes mellitus (T2DM).Data from US physician electronic health records (Humedica®) 2009-2011 were utilized. Patients defined as having above-target if they had an HbA1c ≥7% at any time during study period. Multinomial logistic regressions conducted separately for T1DM T2DM patients, examined associations BMI categories probability of (≥7% <8%, ≥8% <9%, ≥9%) while controlling patient...
The aim of the present study was to determine treatment outcome and prognostic factors for survival in patients with peripheral intrahepatic cholangiocarcinoma (ICC). A retrospective chart review performed diagnosed ICC between 2000 2009 at a single institution. We identified total 105 ICC. Among them, 63.8% were older than 60 years age, 50.5% male 88.6% Caucasian. By preoperative imaging approximately half (50.5%) surgical candidates underwent resection. other (49.5%) unresectable....
To investigate breast cancer-specific mortality by early cancer (EBC; Stages I-IIIC) subtype; incidence of high-risk indicators for recurrence (defined in monarchE trial); and risk difference those who did/did not meet these criteria.Analyses included patients with initial EBC diagnosis between 2010-2015 from Surveillance, Epidemiology, End Results (SEER) data (n = 342,149). Cox proportional hazards models Kaplan-Meier estimates examined among 228,031 patients, subtype (hormone receptor...