Alopecia areata is a common cause of nonscarring alopecia that occurs in patchy, confluent, or diffuse pattern. Dermoscopy noninvasive technique for the clinical diagnosis many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used treatment areata. We aimed to evaluate efficacy PRP versus topical AA by evaluation trichoscopic examination. Ninety patients were allocated into three groups; first was treated with solution, second platelets...

Despite the wide therapeutic options available for treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control this disorder is extremely challenging.To evaluate effect microneedling vitamin C in melasma.Thirty female patients melasma received six sessions addition every two weeks. At each session, photos were taken Melasma Area Severity Index (MASI) score was calculated to assess improvement.Mean age eligible 33.2 ± 5.77 years....

Acne vulgaris is the most common dermatological condition encountered in adolescents.It was to determine prevalence of acne and its impact quality life among adolescents attending secondary schools Sohag Province, Upper Egypt.This a cross-sectional study conducted randomly selected governmental technical Egypt. Approval taken from scientific research committee Faculty Medicine also Ministry Education. Every student with subjected full medical history local examination head neck assess...

Background: Plantar warts are skin lesions on the surface of foot resulting from infection keratinocytes by human papilloma virus. Intralesional bleomycin and 5- fluorouracil (5-FU) therapeutic options utilized to treat various dermatological conditions including planter warts. Objectives: This study aimed compare efficacy safety intralesional injection versus 5-FU in patients with plantar Methods: Randomized comparative interventional included 60 complaining warts, they were divided...

Diabetes mellitus, particularly type 2 diabetes, is a growing global health issue, often exacerbated by insulin resistance, metabolic disturbances, and inflammatory responses. Emodin, natural anthraquinone derivative, has been widely recognized for its

Abstract Background: Plantar wart is a common viral infection occurring in the plantar aspect of foot, caused by human papillomavirus (HPV). Intra-lesional immunotherapy has emerged as front-runner treatment option for warts. Objectives: This study aimed to compare efficacy and tolerability intra-lesional injections acyclovir versus candida antigen patients with Methods: randomised-controlled clinical trial was conducted on 40 The included were randomly assigned into two groups: Group 1 (n =...

Acne scarring is a common undesirable complication of acne vulgaris. Fractional erbium-yttrium aluminum garnet (YAG) 2940 nm laser and platelet-rich plasma have been used in treating scars with variable outcomes. The objective this study to assess the efficacy fractional erbium-YAG as single line treatment comparison combined atrophic postacne scars. Seventy-five patients were included trial randomized into three equal groups (25 each). Group A was subjected six sessions for 6 months, group...

Summary Objectives The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role IL‐17 and 25 hydroxycholecalciferol (25(OH)D3) in disease pathogenesis progression. Materials Methods Across‐sectional has been conducted on 135 patients with active vulgaris various severities 150 matched controls. ELISA assays serum tissue levels 25(OH)D3, also immunohistochemical Western blotting demonstration expression patterns...

Acrosome has a vital role in the process of penetration zona pellucida (ZP). It is highly susceptible to elevated reactive oxygen species (ROS) and oxidative stress (OS). As generally accepted that OS deteriorating effects on sperm functions, we studied effect parameters acrosomal structure infertile patients with normal semen parameters. 30 20 fertile controls were included this study. Semen analysis was performed according WHO Oxidative evaluated by measurement Malondialdehyde (MDA)....

Idiopathic oligoathenoteratozoospermia (iOAT) is a common finding in the evaluation of male infertility. Oxidative stress (OS) may underlie its pathology. Tamoxifen and l-carnitine are used to treat idiopathic The aim this work was detect efficacy tamoxifen on sperm parameters, ultrastructure seminal OS iOAT patients. Sixty patients were recruited for study divided into three groups; 1st treated with tamoxifen, 2nd 3rd both drugs. Semen analysis, malondialdehye (MDA) level transmission...

Cutaneous warts (CW), or verrucae, are benign proliferation of skin that result from infection with human papilloma viruses. Cellular immune reactivity plays a significant role in wart regression. The aim this study was to elucidate the cellular status patients CW through measurements their serum levels interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF,) and, identify possible IL-17 MIF CW. We assessed different forms compare results controls.Serum were measured using...

Nerve growth factor (NGF) and its high-affinity receptor, tyrosine kinase A (TrkA), are members of the neurotrophin family. NGF-TrkA involved in murine hair morphogenesis cycling. To date, their expression human follicle (HF) is unknown. In this investigation, we hypothesize that proteins expressed scalp skin. Moreover, HF changes with transitions from anagen-->>catagen-->>telogen stages.To test our hypothesis to fill existing gap literature, immunostaining values (semiquantitative...

Background Neurotrophin (NT)‐3 and its high‐affinity receptor tyrosine kinase C (Trk C) are essential for nervous system development. These members of the NT family also involved in murine hair morphogenesis cycling. However, their role human follicle (HF) biology remains to be elucidated. Objectives To explore NTs skin HF biology. Methods The immunoreactivity (IR) NT‐3 Trk was studied scalp HFs by immunofluorescent light microscopic immunohistology. Skin biopsies were obtained from normal...

Background Dermoscopy is a simple and inexpensive diagnostic technique that permits the visualization of morphologic features are not visible to naked eye, forming link between clinical dermatology microscopic dermatopathology. For many years, skin biopsy was considered only definite tool confirms or excludes diagnosis. Skin biopsies invasive have adverse effects precautions.Objective To evaluate accuracy dermoscope in diagnosis tumors its correlation with pathological diagnosis.Patients...

To verify and compare the therapeutic efficacy safety of superficial cryotherapy using dimethyl ether propane (DMEP) mixture vs. microneedling in treatment mild scalp alopecia areata (AA). In a prospective randomized single-blinded clinical trial, 80 patients with clinically evident AA were randomly assigned into two groups 40 each. Group (1) was treated by DMEP three freeze-thaw cycles 5 s (2) microneedling. Both every 2 weeks for 6 sessions followed up 3 months after last session. Patients...

Abstract Introduction Erectile dysfunction (ED) can precede coronary artery disease. In addition, silent myocardial ischemia (SMI) is more common in diabetic patients and a strong predictor of cardiac events death. Aim To evaluate the presence SMI with diabetes ED using multidetector computed tomographic angiography (MDCT-CA). Methods This study evaluated without any history symptoms or signs. function was Sexual Health Inventory for Men score, erection hardness score (EHS), maximal penile...

Different modalities are used for treatment of common warts, but none them had been proved the best in achieving complete cure. We aim to compare effect cryotherapy, intralesional injection tuberculin purified protein derivative (PPD) and cryotherapy combined with PPD multiple warts. This study is a randomized clinical trial which patients were randomly divided into three groups; group (A) included 25 subjected (B) (C) plus PPD. All groups showed significant improvement (p < 0.001)...