A5001470140- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Systemic Sclerosis and Related Diseases
- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Inflammatory Myopathies and Dermatomyositis
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- Long-Term Effects of COVID-19
- Vasculitis and related conditions
- Emergency and Acute Care Studies
- Heat shock proteins research
- Transplantation: Methods and Outcomes
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Cardiovascular Issues in Pregnancy
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
McMaster University
2016-2025
Vancouver General Hospital
2025
University of British Columbia
2021-2025
University of Calgary
2025
University of Toronto
2021-2025
St. Paul's Hospital
2025
St. Paul's Hospital
2025
Université de Montréal
2025
St. Joseph’s Healthcare Hamilton
2013-2024
St Joseph's Health Care
2024
Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain.Patients were enrolled from the Canadian Registry for Pulmonary Fibrosis between 2015 2020. was defined as a relative forced vital capacity (FVC) decline ≥10%, death, transplantation or any two of: FVC ≥5% <10%, worsening respiratory symptoms fibrosis on computed tomography...
Sarcoidosis is a systemic granulomatous disease of unknown cause. Natural improvement with favorable outcome common, but significant number patients present difficult to manage and progressive disease. The identification biomarkers associated activity progression warranted. Extracellular heat shock protein 90 (HSP90) α signaling molecule released by cells that induces proinflammatory through interaction certain receptors, such as lipoprotein receptor-related 1. HSP90α expression in lung...
Extent of fibrosis, defined by the amount honeycombing and traction bronchiectasis, was consistently associated with death or lung transplant across all interstitial disease subtypes in a dose-dependent fashion.
The CAnadian REgistry for Pulmonary Fibrosis (CARE-PF) is a multi-center, prospective registry designed to study the natural history of fibrotic interstitial lung disease (ILD) in adults. aim this cross-sectional sub-study was describe baseline characteristics, risk factors, and comorbidities patients enrolled CARE-PF date. Patients completed questionnaires clinical measurements at enrollment each follow-up visit. Environmental exposures were assessed by patient self-report Charlson...
Abstract Background Infliximab is a monoclonal antibody that binds and neutralizes circulating tumor necrosis factor-alpha, key inflammatory cytokine in the pathophysiology of sarcoidosis. Despite paucity randomized clinical trials, infliximab often considered therapeutic option for refractory disease. Our study aimed to investigate effectiveness patients with Methods Sarcoidosis from three tertiary centres were retrospectively identified by pharmacy records based on treatment infliximab....
Abstract Objectives Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, immunosuppression response. Methods Patients with CTD-ILD had high-resolution chest CT (HRCT) reviewed by expert radiologists blinded clinical data for overall pattern [usual interstitial pneumonia (UIP); non-specific (NSIP); organizing (OP); fibrotic hypersensitivity pneumonitis (fHP); other]. Transplant-free...
Background . The relative rarity and diversity of fibrotic interstitial lung disease (ILD) have made it challenging to study these diseases in single-centre cohorts. Here we describe formation a multicentre Canadian registry that is needed the outcomes ILD enable detailed healthcare utilization analyses will be cornerstone for future planning. Methods Registry Pulmonary Fibrosis (CARE-PF) prospective cohort anticipated consist at least 2,800 patients with ILD. CARE-PF used (1) natural...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an unknown cause. Two drugs, nintedanib and pirfenidone, have been shown to slow, but not stop, progression. Pulmonary hypertension (PH) frequent complication in IPF patients associated poor prognosis. Macitentan dual endothelin receptor antagonist that approved for arterial treatment. We hypothesised using macitentan treat animals induced by adenoviral vector encoding biologically active transforming growth factor-β1...
Rationale The European Quality of Life 5-Dimensions 5-Levels questionnaire (EQ-5D-5L) is a multidimensional patient-reported that supports calculation quality-adjusted life-years. Our objectives were to demonstrate feasibility use and calculate the minimum important difference (MID) EQ-5D-5L its associated visual analogue scale (EQ-VAS) in patients with fibrotic interstitial lung disease (ILD). Methods Patients who completed identified from prospective multicentre CAnadian REgistry for...
The impact of pulmonary rehabilitation (PR) on survival in patients with fibrotic interstitial lung disease (ILD) is unknown. Given the challenges conducting a large randomised controlled trial, we aimed to determine whether improvement 6-minute walk distance (6MWD) was associated better survival.This retrospective, international cohort study included ILD participating either inpatient or outpatient PR at 12 sites 5 countries. Multivariable models were used estimate association between...
Rationale: Pulmonary rehabilitation improves dyspnea and exercise capacity in idiopathic pulmonary fibrosis (IPF); however, it is unknown whether breathing high amounts of oxygen during training leads to further benefits.Objectives: Herein, we describe the design High Oxygen Delivery Preserve Exercise Capacity IPF Patients Treated with Nintedanib study (the HOPE-IPF study). The primary objective this determine physiological perceptual impact levels patients who are receiving antifibrotic...
Abstract Background and objective Physical frailty is associated with increased mortality hospitalizations in older adults. We describe the prevalence of physical its prognostic impact patients a spectrum fibrotic interstitial lung disease (ILD). Methods Patients ILD at McMaster University programme were prospectively followed up from November 2015 to March 2020. Baseline data used classify as non‐frail (score = 0), pre‐frail 1–2) or frail 3–5) based on modified Fried criteria. The...
Abstract Background and objective Inhalational exposures are a known cause of interstitial lung disease (ILD), but little is understood about their prevalence across ILD subtypes relationship with pulmonary function survival. Methods Patients fibrotic were identified from the multicentre Canadian Registry for Pulmonary Fibrosis. completed questionnaires regarding ILD‐related occupational environmental exposures. The between outcomes baseline age, gender, family history, survival was analysed...
Abstract Background Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, mortality in patients interstitial lung disease (ILD). However, it is unclear how comorbidities lead to these negative outcomes whether they could influence ILD progression. The goal this study was identify clusters based on similar comorbidity profiles determine were rate function decline and/or mortality. Methods Patients a major fibrotic (idiopathic pulmonary...
Survivors of severe SARS-CoV-2 infections frequently suffer from a range post-infection sequelae. Whether survivors mild or asymptomatic can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype function in individuals who had recovered (
Previous studies have shown the importance of frailty in patients with fibrotic interstitial lung disease (ILD).