A5082962100- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Cardiovascular Effects of Exercise
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Pulmonary Hypertension Research and Treatments
- Physical Activity and Health
- Sports Performance and Training
- Behavioral Health and Interventions
- Respiratory and Cough-Related Research
- Health and Wellbeing Research
- Cardiac Health and Mental Health
- Thermoregulation and physiological responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Delphi Technique in Research
- Nutrition and Health in Aging
- Cardiac Arrest and Resuscitation
- Exercise and Physiological Responses
- Body Composition Measurement Techniques
- Renal function and acid-base balance
- Cannabis and Cannabinoid Research
McGill University
2016-2025
McGill University Health Centre
2016-2025
Royal Victoria Hospital
2023
University of Copenhagen
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2018-2020
Universitätsklinikum Erlangen
2018-2020
GTx (United States)
2018
Providence St. Peter Hospital
2009-2018
Canadian Respiratory Research Network
2016
Queen's University
2004-2011
Several studies in mild chronic obstructive pulmonary disease (COPD) have shown a higher than normal ventilatory equivalent for carbon dioxide ([Formula: see text]e/[Formula: text]co2) during exercise. Our objective was to examine gas exchange abnormalities and the mechanisms of high [Formula: text]co2 COPD its impact on dyspnea exercise intolerance.Twenty-two subjects (11 patients with GOLD [Global Initiative Chronic Obstructive Lung Disease] grade 1B COPD, 11 age-matched healthy control...
Rationale: Outdoor air pollution is a potential risk factor for lower lung function and chronic obstructive pulmonary disease (COPD). Little known about how airway abnormalities growth might modify this relationship. Objectives: To evaluate the associations of ambient exposure with COPD examine possible interactions dysanapsis. Methods: We made use cross-sectional postbronchodilator spirometry data from 1,452 individuals enrolled in CanCOLD (Canadian Cohort Obstructive Lung Disease) study...
Rationale: It is increasingly recognized that adults with preserved ratio impaired spirometry (PRISm) are prone to increased morbidity. However, the underlying pathophysiological mechanisms unknown. Objectives: Evaluate of dyspnea and reduced exercise capacity in PRISm. Methods: We completed a cross-sectional analysis CanCOLD population-based study. compared physiological responses 59 participants meeting PRISm spirometric criteria (post-bronchodilator FEV1<80% predicted FEV1/FVC≥0.7), 264...
The natural history of lung hyperinflation in patients with airway obstruction is unknown. In particular, little information exists about the extent air trapping and its reversibility to bronchodilator therapy those mild obstruction. We completed a retrospective analysis data from individuals who attended our pulmonary function laboratory had plethysmographic volume measurements pre- post-bronchodilator (salbutamol). COPD was likely predominant diagnosis but asthma may have been included....
Dyspnoea and activity limitation can occur in smokers who do not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are unknown. Detailed function tests sensory–mechanical relationships during incremental exercise with respiratory pressure measurements diaphragmatic electromyography (EMG di ) were compared 20 without COPD age-matched healthy controls. Smokers (mean± sd post-bronchodilator forced expiratory volume 1 s (FEV )/forced vital...
What is the central question of this study? Does combination a higher neural respiratory drive and greater dynamic mechanical ventilatory constraints during exercise in healthy women versus men form mechanistic basis sex differences activity-related dyspnoea? main finding its importance? Sex dyspnoea health primarily reflected awareness needed to achieve any given ventilation setting relatively women. These findings may have implications for our understanding mechanisms exertional variants...
The objective of the present study was to evaluate effect morphine on exertional breathlessness and exercise endurance in advanced chronic obstructive pulmonary disease (COPD). In a randomised crossover trial, we compared acute immediate-release oral versus placebo physiological perceptual responses during constant-load cardiopulmonary cycle testing (CPET) 20 adults with COPD syndrome. Compared placebo, reduced at isotime by 1.2±0.4 Borg units increased time 2.5±0.9 min (both p≤0.014)....
Rationale: Impaired exercise ventilatory efficiency (high requirements for CO2 [V˙e/V˙co2]) provides an indication of pulmonary gas exchange abnormalities in chronic obstructive disease (COPD). Objectives: To determine 1) the association between high V˙e/V˙co2 and clinical outcomes (dyspnea capacity) its relationship to lung function structural radiographic abnormalities; 2) prevalence a large population-based cohort. Methods: Participants were recruited randomly from population underwent...
Sewage sludge is frequently applied as fertilizers to cultivated land. However, municipal sewage often contains organic contaminants including nonylphenol (NP), an intermediate from nonionic surfactant degradation. Knowledge about NP degradation in sludge-amended soil important prerequisite for adequate risk assessments. In this study, mineralization of 14C-labeled homogenized and nonhomogenized sludge-soil mixtures was investigated. degraded within 38 days aerobic mixtures. nonhomogeneous...
This study examined the effects of human pregnancy on central chemoreflex control breathing. Subjects were two groups (n=11) pregnant subjects (PG, gestational age, 36.5+/-0.4 wk) and nonpregnant (CG), equated for mean body height, prepregnant mass, parity, aerobic fitness. All performed a hyperoxic CO2 rebreathing procedure, which includes prior hyperventilation maintenance iso-oxia. Resting blood gases plasma progesterone estradiol concentrations measured. During trials, end-tidal Pco2...
<h3>Background:</h3> This study examined the effects of inhaled furosemide on ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD). <h3>Methods:</h3> In a randomised, double-blind, placebo-controlled, crossover study, 20 patients with COPD (mean (SD) forced expiratory volume 1 s 45 (15)% predicted) received either nebulised 40 mg or placebo two separate days. Thirty minutes after each treatment, performed function...
Understanding sex differences in the qualitative dimensions of exertional dyspnea may provide insight into why women are more affected by this symptom than men. This study explored evolution 70 healthy, young, physically active adults (35 M and 35 F). Participants rated intensity their breathing discomfort (Borg 0-10 scale) selected phrases that best described from a standardized list (work/effort, unsatisfied inspiration, expiration) throughout each stage symptom-limited incremental-cycle...
A series of studies conducted approximately 40 years ago demonstrated an acute bronchodilator effect smoked cannabis in healthy adults and with asthma. However, the effects vaporized on airway function advanced chronic obstructive pulmonary disease (COPD) remain unknown.To test hypothesis that inhaled would alleviate exertional breathlessness improve exercise endurance by enhancing static dynamic COPD.In a randomized controlled trial 16 COPD (forced expiratory volume 1 second [FEV1], mean ±...
Abstract Background Impaired gait plays an important role for quality of life in patients with Huntington’s disease (HD). Measuring objective parameters HD might provide unbiased assessment motor deficits order to determine potential beneficial effects future treatments. Objective To objectively identify characteristic features using sensor-based analysis. Particularly, were correlated the Unified Disease Rating Scale, total score (TMS), and functional capacity (TFC). Methods Patients...
Abstract In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea generally arises when there is imbalance between ventilatory demand and capacity, but the neurophysiological mechanisms are unclear. We therefore determined if disparity elevated inspiratory neural drive (IND) tidal volume ( V T ) responses (neuromechanical dissociation) impacted intensity quality during exercise, across COPD severity spectrum. this two‐centre, cross‐sectional observational study, 89...