A5018791863- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Trauma Management and Diagnosis
- Occupational and environmental lung diseases
- Pneumothorax, Barotrauma, Emphysema
- Ultrasound in Clinical Applications
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Lymphatic Disorders and Treatments
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Global Cancer Incidence and Screening
- Photodynamic Therapy Research Studies
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer survivorship and care
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
Ottawa Hospital
2015-2024
University of Ottawa
2014-2024
Ottawa Hospital Research Institute
2013-2021
Queensway-Carleton Hospital
2018
University of Alberta
2018
Ottawa University
2013
Queen's University
2000-2008
Universitair Ziekenhuis Brussel
2008
University of California, San Diego
2006
National and Kapodistrian University of Athens
2006
Major issues in the implementation of screening for lung cancer by means low-dose computed tomography (CT) are definition a positive result and management nodules detected on scans. We conducted population-based prospective study to determine factors predicting probability that first CT scans malignant or will be found follow-up.We analyzed data from two cohorts participants undergoing screening. The development set included Pan-Canadian Early Detection Lung Cancer Study (PanCan). validation...
IntroductionLung cancer risk prediction models have the potential to make programs more affordable; however, economic evidence is limited.MethodsParticipants in National Lung Cancer Screening Trial (NLST) were retrospectively identified with tool developed from Prostate, Lung, Colorectal and Ovarian Trial. The high-risk subgroup was assessed for lung incidence demographic characteristics compared those low-risk Pan-Canadian Early Detection of Study (PanCan), which an observational study that...
Rationale: The exact site(s) and pathophysiology of air leakage in patients with primary spontaneous pneumothorax (PSP) are unknown. In one patient PSP, fluorescein-enhanced autofluorescence thoracoscopy (FEAT) has shown areas parenchymal abnormality unnoticed during white light (WLT).Objectives: To prospectively perform compare WLT FEAT normal subjects.Methods: One-time inspection systematic mapping semiquantified lesions 12 consecutive PSP was compared one-time sequential bilateral 17...
<i>Background:</i> Interventional bronchoscopic procedures can re-establish airway patency in the majority of individuals suffering from endobronchial obstruction. However, literature provides limited data on impact these individual’s quality life (QoL). <i>Objectives:</i> We evaluated interventional aimed at re-establishing symptoms and QoL who do not receive concomitant chemotherapy or radiation therapy. <i>Methods:</i> Over a 6-month period, we...
<h3>Background:</h3> This study examined the effects of inhaled furosemide on ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD). <h3>Methods:</h3> In a randomised, double-blind, placebo-controlled, crossover study, 20 patients with COPD (mean (SD) forced expiratory volume 1 s 45 (15)% predicted) received either nebulised 40 mg or placebo two separate days. Thirty minutes after each treatment, performed function...
<b><i>Background:</i></b> Tunneled pleural catheters (TPC) are used in the management of malignant effusions (MPE), but impact this palliative procedure on patient quality life (QoL) has not been well described. <b><i>Objectives:</i></b> To ascertain TPCs symptoms and QoL patients with recurrent MPE. <b><i>Methods:</i></b> Patients MPE completed EORTC QLQ-C30 LC13 questionnaires at baseline, 2 14 weeks;...
Exertional dyspnea is an important symptom in cancer patients, and, many cases, its cause remains unexplained after careful clinical assessment. To determine mechanisms of exertional a variety types, we evaluated outpatients with clinically (CD) at rest and during exercise compared the results age-, sex-, stage-matched control (CC) patients age- sex-matched healthy participants (HC). Participants (n = 20/group) were screened to exclude cardiopulmonary disease then completed questionnaires,...
It is estimated that millions of North Americans would qualify for lung cancer screening and billions dollars national health expenditures be required to support population-based computed tomography programs. The decision implement such programs should informed by data on resource utilization costs.Resource were collected prospectively from 2059 participants in the Pan-Canadian Early Detection Lung Cancer Study using low-dose (LDCT). Participants who had 2% or greater risk over 3 years a...
Background Indwelling pleural catheters are an effective treatment option for patients with malignant effusions. Despite their popularity, there remains a paucity of data on the patient experience and key patient-centred outcomes. Objective To investigate receiving indwelling catheter to better inform identify potential areas improvement in care. Methods This was multicentre survey study at three academic, tertiary-care centres Canada. Patients diagnosis effusion who had inserted were...
Background . Treatment options are limited for patients with refractory cirrhotic ascites (RCA). As such, we assessed the safety and effectiveness of PleurX catheter RCA. Methods A retrospective analysis was performed on all RCA who have undergone insertion between 2007 2014 at our clinic. Results Thirty-three were included in study; 4 lost to follow-up. All still symptomatic despite bimonthly large volume paracentesis not candidates TIPS or PV shunt. Technical success achieved 100%...
A 61-year-old woman with locally advanced, high-grade urothelial cell carcinoma was treated the anti-programmed death-ligand 1 antibody atezolizumab. She initially received neoadjuvant chemotherapy and surgery that led to clinical radiographic remission at time of atezolizumab initiation. Within 3 months she developed new mediastinal hilar lymphadenopathy as well pulmonary nodules in a pattern characteristic sarcoidosis. Mediastinal lymph node biopsy by endobronchial ultrasound demonstrated...
BACKGROUND: Management of malignant pleural effusion typically involves insertion an indwelling catheter (IPC) or chemical pleurodesis with agents such as talc. OBJECTIVES: To compare these management strategies regard to success management. METHODS: A retrospective cohort study was designed comparing patients and paramalignant effusions Eastern Cooperative Oncology Group performance status <4 managed IPC talc (TP) through tube thoracostomy during non‐contemporary three‐year periods at a...
Pleural effusions are a common complication of end-stage renal disease.These occasionally refractory to medical management, but few options then available. Indwelling pleural catheter insertion (IPC) has been well described for the management malignant and, more recently, nonmalignant other origin. We aimed analyze our experience and evaluate safety feasibility using IPCs effusion associated with disease.We constructed cohort patients who underwent IPC disease. The were inserted as...
We investigated use of the tunnelled catheter in a large palliative population with malignancy-associated ascites employing retrospective analysis prospectively maintained patient database peritoneal insertions for refractory or new rapidly accumulating ascites. found that 100 percent procedural success rate was achieved 395 catheters inserted 386 patients. Catheters remained situ 66 days, on average. In total 22 cases (5.57 percent), complications developed. Nonfatal infections occurred...
Malignant pleural effusions (MPEs) are associated with significant health service use and healthcare costs, but the current evidence is limited.