A5049578413- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound in Clinical Applications
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Mechanisms and Therapy
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Immunotherapy and Immune Responses
- Chromatin Remodeling and Cancer
- COVID-19 and healthcare impacts
- Pulmonary Hypertension Research and Treatments
McGill University Health Centre
2016-2025
Jewish General Hospital
2019-2024
RELX Group (United States)
2022-2024
Nunavik Regional Board of Health and Social Services
2024
McGill University
2007-2023
La Jolla Alcohol Research
2022-2023
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
Hamilton Health Sciences
2022-2023
Footscray Hospital
2022-2023
Rationale: Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD).Objectives: To examine whether these medications might be associated an excess risk of pneumonia.Methods: We conducted a nested case-control study within cohort COPD from Quebec, Canada, over the period 1988–2003, identified on basis administrative databases linking hospitalization and drug-dispensing information. Each subject hospitalized for pneumonia during follow-up...
Tumor suppressor SMARCA4 (BRG1), a key SWI/SNF chromatin remodeling gene, is frequently inactivated in cancers and not directly druggable. We recently uncovered that loss an ovarian cancer subtype causes cyclin D1 deficiency leading to susceptibility CDK4/6 inhibition. Here, we show this vulnerability conserved non-small cell lung (NSCLC), where also results reduced expression selective sensitivity inhibitors. In addition, SMARCA2, another subunit lost subset of NSCLCs, regulates drug...
Advanced diagnostic bronchoscopy targeting the lung periphery has developed at an accelerated pace over last two decades, whereas evidence to support introduction of innovative technologies been variable and deficient. A major gap relates reporting yield, in addition limited comparative studies.
Severe post tracheostomy (PT) and intubation (PI) tracheal stenosis is an uncommon clinical entity that often requires interventional bronchoscopy before surgery considered. We present our experience with severe PI PT in regards to patient characteristics, possible risk factors, therapy. conducted a retrospective chart review of 31 patients treated at Lahey Clinic over the past 8 years. Demographic body mass index, co-morbidities, type site, procedures performed local treatments applied were...
Abstract The PD-L1 (CD274) immune-checkpoint ligand is often upregulated in cancers to inhibit T cells and elicit immunosuppression. Independent of this activity, has recently been shown also exert a cancer cell–intrinsic function promoting tumorigenesis. Here, we establish tumor-intrinsic role triple-negative breast (TNBC) non–small cell lung (NSCLC). Using FACS-assisted shRNA screens, identified the cell-surface adhesion receptor CD44 as key positive regulator expression these cancers....
Background Studies have reported a high diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis sarcoidosis. We sought to review EBUS-TBNA sarcoidosis at our institution over time, and examine factors that may influence this yield. Methods Patients who underwent suspected between December 2008 November 2011 were identified. EBUS was performed without rapid on-site evaluation (ROSE) samples. The final based on results all invasive...
Abstract Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets ovarian lung cancers. Concomitant loss these key subunits SWI/SNF chromatin remodeling complexes both cancers is associated with chemotherapy resistance poor prognosis. Here, we discover that SMARCA4/2 inhibits chemotherapy-induced apoptosis through disrupting intracellular organelle calcium ion (Ca 2+ ) release By restricting accessibility to ITPR3 , encoding Ca channel IP3R3,...
Abstract Background and objective Little published data exist regarding the learning curve for endobronchial ultrasound‐transbronchial needle aspiration ( EBUS‐TBNA ). We sought to assess improvement in skill as trainees learned a clinical setting. Methods This is multicentre cohort study of technical interventional pulmonology IP ) fellows assessed with computer simulator testing every 25 cases throughout fellowship training. Results Nine from three academic centres U nited S tates C anada...
<b><i>Background:</i></b> Tunneled pleural catheters (TPC) are used in the management of malignant effusions (MPE), but impact this palliative procedure on patient quality life (QoL) has not been well described. <b><i>Objectives:</i></b> To ascertain TPCs symptoms and QoL patients with recurrent MPE. <b><i>Methods:</i></b> Patients MPE completed EORTC QLQ-C30 LC13 questionnaires at baseline, 2 14 weeks;...
Advances in molecular biology are improving the understanding of lung cancer and changing approach to treatment. A satisfactory biopsy that allows for histologic characterization mutation analysis is becoming increasingly important. Most patients with diagnosed at an advanced stage, diagnosis often based on a small or cytology specimen. Here, we review techniques available making cancer, including bronchoscopy, ultrasound-guided mediastinoscopy, transthoracic needle aspiration,...
Rationale: Immunotherapy has become an integral part of management in patients with advanced non–small cell lung cancer (NSCLC). Programmed death ligand 1 (PD-L1) expression at least 50% tumor cells on histologic samples been correlated improved efficacy the immune checkpoint inhibitor pembrolizumab. A limited number studies have examined suitability endobronchial ultrasound–guided transbronchial needle aspiration (EBUS-TBNA) specimens for assessment PD-L1 status. Objective: We sought to...
The field of diagnostic bronchoscopy has developed at an accelerated pace. Certain limitations have plagued the evaluation advanced techniques, including use inconsistently defined measures accuracy, and confusion around definition "diagnostic yield." This methodological review outlines standard accuracy highlights how these differ from We draw examples interventional literature to illustrate key concepts potential pitfalls.
Background Inhaled corticosteroids (ICS) are suggested for potential chemoprevention of lung cancer. Several observational studies in patients with chronic obstructive pulmonary disease (COPD) reported inconsistent results, either significant reductions cancer incidence ICS use or no effect. We assessed this association, using an approach that avoided biases affecting some the studies. Methods A cohort COPD, new users long-acting bronchodilators over 2000–2014, was formed Quebec healthcare...
Abstract RATIONALE: Appropriate management of low-dose computed tomography (LDCT) screening detected lung nodules will have significant implications for health care resource utilization and minimizing harm from radiation exposure related to imaging studies, invasive procedures clinically distress. OBJECTIVES We aimed to: provide a practical, evidence-based best practice framework healthcare professionals (HP) manage LDCT identify areas that require future studies. METHODS The Canadian...