A5036097685- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Cardiac Health and Mental Health
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Delphi Technique in Research
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Sports Performance and Training
- Emergency and Acute Care Studies
- Hemodynamic Monitoring and Therapy
- Chronic Disease Management Strategies
- Balance, Gait, and Falls Prevention
- Health and Wellbeing Research
- Respiratory and Cough-Related Research
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
Covenant Health
2016-2025
University of Alberta
2016-2025
Pulmonary Associates
2010-2024
Alberta Health
2016-2024
Alberta Health Services
2016-2024
Respiratory Clinical Trials
2024
Alberta Hospital Edmonton
2012-2023
La Jolla Alcohol Research
2022-2023
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
Changing arterial oxygen content (C(aO(2))) has a highly sensitive influence on the rate of peripheral locomotor muscle fatigue development. We examined effects C(aO(2)) exercise performance and its interaction with quadriceps fatigue. Eight trained males performed four 5 km cycling time trials (power output voluntarily adjustable) at levels (17.6-24.4 ml O(2) dl(-1)), induced by variations in inspired fraction (0.15-1.0). Peripheral was assessed via changes force pre- versus post-exercise...
In young, healthy people the alveolar-arterial P(O(2)) difference (A-aDO(2)) is small at rest, but frequently increases during exercise. Previously, investigators have focused on ventilation/perfusion mismatch and diffusion abnormalities to explain impairment in gas exchange, as significant physiological intra-pulmonary shunt has not been found. The aim of this study was use a non-gas exchange method determine if anatomical (I-P) shunts develop exercise, and, so, whether there relationship...
BACKGROUND: Pulmonary rehabilitation (PR) is an effective therapeutic strategy to improve health outcomes in patients with chronic obstructive pulmonary disease (COPD); however, there insufficient PR capacity service all COPD patients, thus necessitating creative solutions increase the availability of PR. OBJECTIVE: To examine efficacy delivered via Telehealth (Telehealth-PR) compared person through a standard outpatient hospital-based program (Standard-PR). METHODS: One hundred forty-seven...
BACKGROUND: Pulmonary rehabilitation (PR) is a recommended intervention in the management of individuals with chronic lung disease. It important to study characteristics and capacity programs Canada confirm best practices identify future areas program improvement research. OBJECTIVE: To all Canadian PR programs, regardless setting, comprehensively describe aspects delivery. The present article reports results survey related type program, characteristics. METHODS: All hospitals were contacted...
BACKGROUND Testicular cancer survivors (TCS) have an increased risk of treatment‐related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects high‐intensity aerobic interval training (HIIT) on traditional and novel CVD factors surrogate markers mortality in a population‐based sample TCS. METHODS This phase 2 trial ( ClinicalTrials.gov identifier NCT02459132) randomly assigned 63 TCS to usual care (UC) or 12 weeks supervised HIIT (ie, alternating...
Subjects with greater aerobic fitness demonstrate better diastolic compliance at rest, but whether modulates exercise cardiac and filling pressures remains to be determined. On the basis of maximal oxygen consumption (V̇o 2max ), healthy male subjects were categorized into either low (LO: V̇o = 43 ± 6 ml·kg −1 ·min ; n 3) or high (HI: 60 3 5) power. performed incremental cycle 90% . Right atrial (RAP) pulmonary artery wedge (PAWP) measured, left ventricular (LV) transmural pressure (TMFP...
The 100% oxygen (O(2)) technique has been used to detect and quantify right-to-left shunt for more than 50 years. goal of this study was determine if breathing O(2) affected intrapulmonary arteriovenous pathways during exercise. Seven healthy subjects (3 females) performed two exercise protocols. In Protocol I an incremental cycle ergometer test (60 W + 30 W/2 min; room air, FIO2 = 0.209) shunting evaluated using saline contrast echocardiography at each stage. Once significant documented...
Cerebral blood flow (CBF) is reduced during passive heat stress, with 50% of this reduction associated hyperventilatory-induced hypocapnia and subsequent cerebral vasoconstriction. It remains unknown, however, what other factors may contribute to the remaining 50%. We tested hypothesis that distribution cardiac output plays an important role in maintaining perfusion mild severe stress. Middle artery posterior velocity (MCAv PCAv; transcranial Doppler) left ventricular end-diastolic...
The cardiopulmonary exercise test (CPET) is an important physiological investigation that can aid clinicians in their evaluation of intolerance and dyspnea. Maximal oxygen consumption (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mover...
Although participation in pulmonary rehabilitation (PR) improves the health outcomes patients with Chronic Obstructive Pulmonary Disease (COPD), there are insufficient resources to provide PR all COPD. Thus, predicting which at risk for drop-out and non-response is necessary order optimize limited resources. This study examined patient characteristics predictive of non-response. 814 COPD took part standard out-patient 8 weeks. Demographic clinical data were collected before program had...
Previous work suggests that women may exhibit a greater respiratory limitation in exercise compared with height-matched men. Diffusion capacity (DlCO) increases incremental exercise, and the smaller lungs of limit membrane diffusing (Dm) pulmonary capillary blood volume (Vc) response to increased oxygen demand. We hypothesized would have lower DlCO, DlCO relative cardiac output (DlCO/Q̇), Dm, Vc, transit time, secondary Vc at peak exercise. Sixteen (112 ± 12% predicted V̇o2peak) sixteen men...
Extreme preterm birth confers risk of long-term impairments in lung function and exercise capacity. There are limited data on the factors contributing to limitation following extreme birth. This study examined respiratory mechanics ventilatory response during a large cohort children born extremely (EP).This included 8-12 years age who were EP (≤28 weeks gestation) between 1997 2004 treated regionalised neonatal intensive care unit western Canada. divided into no/mild bronchopulmonary...
Rationale: Impaired exercise ventilatory efficiency (high requirements for CO2 [V˙e/V˙co2]) provides an indication of pulmonary gas exchange abnormalities in chronic obstructive disease (COPD). Objectives: To determine 1) the association between high V˙e/V˙co2 and clinical outcomes (dyspnea capacity) its relationship to lung function structural radiographic abnormalities; 2) prevalence a large population-based cohort. Methods: Participants were recruited randomly from population underwent...
Higher levels of exercise capacity and physical activity are desired outcomes in the comprehensive management COPD patient. In addition, improvements instrumental to optimising other important therapeutic goals, such as improved health status, reduced healthcare utilisation increased survival. Four general approaches towards increasing individuals with will be discussed this review: 1) pharmacological intervention, especially administration long-acting bronchodilators; 2) pulmonary...
The purpose of this study was to test the accuracy 20-m multi-stage shuttle run (SR) predict [Formula: see text] in young adults. measured during a graded treadmill 60 men and 62 women (mean age 25.3 25.1 years, respectively). Each subject familiarized with SR procedure then completed on separate day. mean terminal stage 9.5 for 7.8 women. regression equations Léger et al. (1988) Gadoury (1989) systematically underpredicted text]max both males females (p < 0.05). New were developed from...
Postmortem microsphere studies in adult human lungs have demonstrated the existence of intrapulmonary arteriovenous pathways using nonphysiological conditions. The aim current study was to determine whether large diameter (>25 and 50 μm) are functional baboon under physiological perfusion ventilation pressures. We used fresh healthy donor obtained for transplantion from baboons ( Papio c. anubis). Lungs were ventilated with room air by a peak inflation pressure 15 cmH 2 O positive...