A5035353110- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Cancer survivorship and care
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Chemotherapy-induced cardiotoxicity and mitigation
- Asthma and respiratory diseases
- Childhood Cancer Survivors' Quality of Life
- Cardiac Health and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Lymphatic System and Diseases
- Exercise and Physiological Responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- High Altitude and Hypoxia
- Physical Activity and Health
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Cancer Treatment and Pharmacology
- Cardiomyopathy and Myosin Studies
- Neonatal Respiratory Health Research
University of British Columbia
2016-2025
Kelowna General Hospital
2012-2022
Okanagan University College
2012-2021
University of Calgary
2006-2017
Memorial Sloan Kettering Cancer Center
2017
Grace (United States)
2017
BC Cancer Agency
2016
Vancouver General Hospital
2016
GTx (United States)
2012
Alberta Bible College
2012
Despite the importance of blood flow on brainstem control respiratory and autonomic function, little is known about regional cerebral (CBF) during changes in arterial gases.We quantified: (1) anterior posterior CBF reactivity through a wide range steady-state partial pressures CO2 (PaCO2) O2 (PaO2) blood, (2) determined if internal carotid artery (ICA) vertebral (VA) change diameter same range.We used near-concurrent vascular ultrasound measures ICA VA, velocity their downstream arteries...
To determine the effects of preoperative exercise training on cardiorespiratory fitness in patients undergoing thoracic surgery for malignant lung lesions.Using a single-group design, 25 with suspected operable cancer were provided structured until surgical resection. Exercise consisted 5 endurance cycle ergometry sessions per week at intensities varying from 60% to 100% baseline peak oxygen consumption (VO(2 peak)). Participants underwent cardiopulmonary testing, 6-minute walk (6 MW), and...
Abstract BACKGROUND: Identifying strong markers of prognosis is critical to optimize treatment and survival outcomes in patients with nonsmall cell lung cancer (NSCLC). The authors investigated the prognostic significance preoperative cardiorespiratory fitness (peak oxygen consumption [VO 2peak ]) among operable candidates NSCLC. METHODS: By using a prospective design, 398 potentially resectable NSCLC enrolled Cancer Leukemia Group B 9238 were recruited between 1993 1998. Participants...
A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted.Using a single-group design, 20 with stage I-IIIB NSCLC performed 3 cycle ergometry sessions per week at 60% to 100% peak workload for 14 weeks. Peak oxygen consumption (VO(2peak)) assessed using an incremental test. QOL fatigue were Functional Assessment Cancer Therapy-Lung (FACT-L)...
Summary Objectives To investigate the relationship between weight status (body mass index [BMI] percentile and BMI z ‐score) lung volumes in healthy children adolescents. Hypotheses We hypothesized that: (a) there would be a significant inverse age‐ sex‐specific distribution functional residual capacity (FRC), expiratory reserve volume (ERV), respectively; (b) obese have significantly reduced FRC ERV compared to their non‐obese peers. Methods The medical records of all individuals who...
The purpose of this study was to explore whether methods adapted from oncology pharmacological trials have utility in reporting adherence (tolerability) exercise treatment cancer.Using a retrospective analysis randomized trial, 25 prostate cancer patients received an aerobic training regimen 72 supervised treadmill walking sessions delivered thrice weekly between 55% and 100% capacity for 24 consecutive weeks. Treatment assessed using conventional (lost follow-up attendance) exploratory...
Abstract Aims The most appropriate timing of exercise therapy to improve cardiorespiratory fitness (CRF) among patients initiating chemotherapy is not known. effects administered during, following, or during and following were examined in with breast cancer. Methods results Using a parallel-group randomized trial design, 158 inactive women cancer (neo)adjuvant allocated receive (1:1 ratio): usual care one three regimens—concurrent (during only), sequential (after concurrent (continuous) (n =...
Hyperoxia and normoxic helium independently reduce dynamic hyperinflation improve the exercise tolerance of patients with chronic obstructive pulmonary disease (COPD). Combining these gases could have an additive effect on a greater impact respiratory mechanics tolerance.To investigate whether helium-hyperoxia improves COPD.Ten males COPD (FEV(1) = 47 +/- 17%pred [mean SD]) performed randomized constant-load cycling at 60% maximal work rate breathing air, hyperoxia (40% O(2), N(2)), (21% 79%...
There is evidence that female athletes may be more susceptible to exercise-induced arterial hypoxemia and expiratory flow limitation have greater increases in operational lung volumes during exercise relative men. These pulmonary limitations ultimately lead levels of diaphragmatic fatigue women. Accordingly, the purpose this study was determine whether there are sex differences prevalence severity 38 healthy endurance-trained men (n = 19; maximal aerobic capacity 64.0 +/- 1.9 ml x kg(-1)...
It is not known whether the high total work of breathing (WOB) in exercising women higher due to differences resistive or elastic WOB. Accordingly, purpose this study was determine which factors contribute WOB during exercise women. We performed a comprehensive analysis previous data from 16 endurance-trained subjects (8 men and 8 women) that underwent progressive cycle test exhaustion. Esophageal pressure, lung volumes, ventilatory parameters were continuously monitored throughout exercise....
The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and organ components that govern VO2peak in post-operative non-small cell lung cancer (NSCLC) patients. Using single-center, design, 160 subjects (40 patients/study arm) with histologically confirmed stage I-IIIA NSCLC following curative-intent complete surgical resection at Duke...
Current exercise guidelines for clinical populations recommend an therapy (ET) prescription of fixed intensity (moderate), duration (40-50 minutes per session), and volume (120-160 min/wk). A critical overarching element programming that has received minimal attention is dose scheduling. We investigated the tolerability efficacy 2 training regimens on cardiorespiratory fitness patient-reported outcomes in patients with posttreatment primary breast cancer.Using a parallel-group randomized...
Abstract Background Poor cardiorespiratory fitness (CRF) is a cardinal feature of post‐treatment primary lung cancer. The most effective exercise therapy regimen to improve CRF has not been determined. Methods In this parallel‐group factorial randomized controlled trial, cancer survivors with poor (below age–sex sedentary values) were randomly allocated receive 48 consecutive supervised sessions thrice weekly (i) aerobic training (AT)—cycle ergometry at 55% >95% peak oxygen consumption...