A5085953948- Cancer survivorship and care
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- Lymphatic System and Diseases
- Cancer Risks and Factors
- Cancer-related cognitive impairment studies
- Physical Activity and Health
- Radiation Therapy and Dosimetry
- Cancer Treatment and Pharmacology
- Effects of Radiation Exposure
- Adipokines, Inflammation, and Metabolic Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Clinical practice guidelines implementation
- Glioma Diagnosis and Treatment
- Sports injuries and prevention
University of British Columbia
2016-2025
University of the Fraser Valley
2023
Health Net
2023
National Institutes of Health
2023
Oregon Health & Science University
2011-2022
University of Alberta
2004-2022
Alberta Health Services
2010-2022
University of Calgary
2010-2022
Canadian Physiotherapy Association
2022
McGill University
2016-2022
The number of cancer survivors worldwide is growing, with over 15.5 million in the United States alone-a figure expected to double coming decades. Cancer face unique health challenges as a result their diagnosis and impact treatments on physical mental well-being. For example, often experience declines functioning quality life while facing an increased risk recurrence all-cause mortality compared persons without cancer. 2010 American College Sports Medicine Roundtable was among first reports...
Multiple organizations around the world have issued evidence‐based exercise guidance for patients with cancer and survivors. Recently, American College of Sports Medicine has updated its prevention as well treatment a variety health‐related outcomes (eg, fatigue, anxiety, depression, function, quality life). Despite these guidelines, majority people living beyond are not regularly physically active. Among reasons this is lack clarity on part those who work in oncology clinical settings their...
Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This particularly true postmenopausal women; a population with high prevalence toward whom fewer studies targeted. We conducted year-long, 4-arm randomized trial among 439 overweight-to-obese sedentary women to determine effects calorie-reduced, low-fat diet (D), moderate-intensity, facility-based aerobic exercise program (E), or combination both (D+E), vs. no-lifestyle-change...
Abstract Obese and sedentary persons have increased risk for cancer; inflammation is a hypothesized mechanism. We examined the effects of caloric restriction weight loss diet exercise on inflammatory biomarkers in 439 women. Overweight obese postmenopausal women were randomized to 1-year: (goal 10% loss, N = 118), aerobic (225 min/wk moderate-to-vigorous activity, 117), combined + (N or control 87). Baseline 1-year high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA),...
The objectives of the present study were to evaluate impact a single bout high-intensity aerobic exercise on 1) long-term potentiation (LTP)-like neuroplasticity via response paired associative stimulation (PAS) and 2) temporal spatial components sequence-specific implicit motor learning. Additionally, relationships between exercise-induced increases in systemic brain-derived neurotrophic factor (BDNF) PAS learning evaluated. Sixteen young healthy participants completed six experimental...
Exercise has been underutilized in people with advanced or incurable cancer despite the potential to improve physical function and reduce psychosocial morbidity, especially for bone metastases because of concerns over skeletal complications. The International Bone Metastases Working Group (IBMEWG) was formed develop best practice recommendations exercise programming on basis published research, clinical experience, expert opinion.The IBMEWG undertook sequential steps inform recommendations:...
We examined how an aerobic exercise intervention influenced circulating estradiol, estrone, sex hormone-binding globulin (SHBG), androstenedione, and testosterone levels, which may be involved in the association between physical activity breast cancer risk.
Abstract Background Although lifestyle interventions targeting multiple behaviors are more effective in preventing unhealthy weight gain and chronic diseases than intervening on a single behavior, few studies have compared individual combined effects of diet and/or exercise health-related quality life (HRQOL). In addition, the mechanisms how these affect HRQOL unknown. The primary aim this study was to examine dietary loss psychosocial factors (depression, anxiety, stress, social support)....
Estrogens and androgens are elevated in obesity associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated individual combined effects a reduced-calorie diet exercise serum sex hormones overweight obese women.We conducted single-blind, 12-month, randomized controlled trial from 2005 to 2009. Participants (age 50 75 years; body mass index > 25.0 kg/m(2), exercising < 100 minutes/wk) were randomly assigned using...
To investigate the effect of a yearlong moderate-intensity aerobic exercise intervention on C-reactive protein (CRP), serum amyloid A (SAA), and interleukin 6 (IL-6) among overweight or obese postmenopausal women.In randomized controlled trial, 115 postmenopausal, obese, sedentary women, aged 50-75 yr were to an (60%-75% observed maximal HR), for > = 45 min x d(-1), 5 d wk (n 53), 1-d wk(-1) stretching control 62), intent-to-treat basis. CRP, SAA, IL-6 measured at baseline, 3 months, 12...
Abstract Background Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration adipose‐derived adiponectin leptin levels. We investigated effects 12‐month reduced calorie, loss exercise interventions on concentrations. Methods Overweight/obese postmenopausal women ( n = 439) were randomized as follows: (i)...
Physical activity is a known modifiable lifestyle means for reducing postmenopausal breast cancer risk, but the biologic mechanisms are not well understood. Metabolic factors may be involved. In this study, we aimed to determine effects of exercise on insulin resistance (IR) indicators, IGF1, and adipokines in women. The Alberta Activity Breast Cancer Prevention Trial was two-armed randomized controlled trial postmenopausal, inactive, cancer-free A year-long aerobic intervention 225 min/week...