A5101429322- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Plant Genetic and Mutation Studies
- Pharmacogenetics and Drug Metabolism
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Magnolia and Illicium research
- Estrogen and related hormone effects
- Phytoestrogen effects and research
- Ecology and Conservation Studies
- Phytochemistry and biological activity of medicinal plants
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Cardiac Ischemia and Reperfusion
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Cancer therapeutics and mechanisms
- Light effects on plants
- Phytochemicals and Antioxidant Activities
- Transplantation: Methods and Outcomes
- Ginseng Biological Effects and Applications
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Phytochemical Studies and Bioactivities
- Metabolism, Diabetes, and Cancer
Anqing Normal University
2014-2024
Hubei Provincial Center for Disease Control and Prevention
2011-2024
Inner Mongolia University
2009-2023
Chongqing University
2014-2021
Chongqing Emergency Medical Center
2021
Southern Medical University
2015-2020
Nanfang Hospital
2020
ZheJiang Institute For Food and Drug Control
2018
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2018
Second Military Medical University
2015-2017
Abstract Background Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration adipose‐derived adiponectin leptin levels. We investigated effects 12‐month reduced calorie, loss exercise interventions on concentrations. Methods Overweight/obese postmenopausal women ( n = 439) were randomized as follows: (i)...
Abstract Background In Chinese traditional medicine, Agrimonia pilosa Ledeb (APL) exhibits great effect on treatment of type 2 diabetes mellitus (T2DM), however its mechanism is still unknown. Considering that T2DM are correlated with postprandial hyperglycemia and oxidative stress, we investigated the α-glucosidase inhibitory activity antioxidant flavonoid compound (FC) triterpenoid (TC) from APL. Methods Entire plants APL were extracted using 95% ethanol 50% successively. The resulting...
Background Testudinis Carapax et Plastrum (TCP), derived from the Chinemys reevesii (Gray) species, is a traditional Chinese medicinal material with demonstrated pharmacological activity in decoctions and extracts. However, other species-sourced substitutes are sometimes used market, potentially impairing quality effectiveness of TCP medications. To address this issue, systematic characterization metabolite lipid profiles their critical for establishing assessment criteria. Methods Liquid...
In our effort to develop multifunctional compounds that cotarget beta-amyloid oligomers (AβOs), cell membrane/lipid rafts (CM/LR), and oxidative stress, a series of bivalent Aβ oligomerization inhibitors (BMAOIs) containing cholesterol curcumin were designed, synthesized, biologically characterized as potential treatments for Alzheimer's disease (AD). The in vitro assay results established the length spacer links attaching position on are important structural determinants their biological...
Herein we report the discovery of C-2 methyl substituted imidazopyrrolopyridine series and its optimization to provide potent orally bioavailable JAK1 inhibitors with selectivity over JAK2. The inhibitor 4 exhibited not only improved potency relative unsubstituted compound 3 but also notable vs JAK2 (20-fold >33-fold in biochemical cell-based assays, respectively). Features X-ray structures complex both are delineated. Efforts improve vitro vivo ADME properties while maintaining described,...
Allergic diseases, such as asthma and allergic rhinitis, are common. Therefore, the discovery of therapeutic drugs for these conditions is essential. Methyleugenol (ME) a natural compound with antiallergic, antianaphylactic, antinociceptive, anti-inflammatory effects. This study examined antiallergic effect ME on IgE-mediated inflammatory responses its antiallergy mechanism in mast cell line, RBL-2H3. We found that significantly inhibited release β-hexosaminidase, tumor necrosis factor-...
Inhibition of UDP-glucuronosyltransferases (UGTs) can result in many undesired side effects. Diethylstilbestrol (DES), a synthetic oestrogen famous for its multiple toxicities, was once widely administered to women high dosages and now still gains application clinics. This study investigated vitro inhibitory effects DES on catalytic activities human UGTs, aiming at disclosing new potential toxic mechanisms the basis interactions between metabolizing enzymes. (10 μM) could decrease UGT1A1,...
Abstract Glucuronidation of SN ‐38 serves as an important metabolic pathway in determining the toxic effects irinotecan. The role UDP ‐glucuronosyltransferases ( UGT ) 1A9 glucuronidation is very confusing. This study re‐investigates through testing bovine serum albumin BSA and selective inhibitor on pooled human liver microsomes HLM recombinant 1A1/ 1A9. For 1A1, was little affected by . Whether presence or not, reactions both obey Michaelis–Menten kinetics with closed Vmax/Km values. , can...
Pharmacognosy Magazine,2015,11,41,219-225.DOI:10.4103/0973-1296.149741Published:January 2015Type:Original ArticleAuthors:Tingwang Guo, Liancai Zhu, Jun Tan, Xuemei Zhou, Ling Xiao, Xi Liu, and Bochu Wang Author(s) affiliations:Tingwang Guo1, Zhu1, Tan2, Zhou1, Xiao1, Liu1, Wang1 1 Key Laboratory of Biorheological Science Technology, Ministry Education, College Bioengineering, Chongqing University, Chongqing, China 2 School Biological Chemical Engineering, University Abstract:Background:...
The peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in adipocyte differentiation and insulin sensitivity. Its ligand rosiglitazone has anti-diabetic effect but is frequently accompanied with some severe unwanted effects. aim of the current study was to compare CMHX008, a novel thiazolidinedione-derivative, rosiglitazone. A luciferase assay used evaluate vitro PPARγ activation. 3T3-L1 cells were examine differentiation. High fat diet (HFD) mice vivo mRNA levels...
Mutagenic interactions between maleic hydrazide (MH; a promutagen known to be activated into mutagen in plant cells) and X rays were studied the stamen hairs of Tradescantia clone BNL 4430, blue/pink heterozygote. The young inflorescence-bearing shoots with roots cultivated nutrient solution circulating growth chamber used as tester plants. After determining doseresponse curves for MH, nine combined treatments MH (0.5 1 mM) (292 1,240 mGy) conducted, exposing either 20 or 44 h before, at...
For establishing more efficient blue /pink heterozygous Tradescantia testers of mutagenicity, the young inflorescence-bearing nodal and/or axillary cuttings clones BNL 02, KU 27, 7 and 20 were cultivated with nutrient solutions, flower production, stamen-hair growth, spontaneous induced somatic pink mutation frequencies in stamen hairs observed each clone compared those potted plants same clone. The tended to show poorer productions, smaller sizes decreases number hairs, as plants, but...