A5053101829- Diet and metabolism studies
- Nutritional Studies and Diet
- Eating Disorders and Behaviors
- Adipokines, Inflammation, and Metabolic Diseases
- HIV/AIDS Research and Interventions
- Obesity, Physical Activity, Diet
- HIV, Drug Use, Sexual Risk
- Global Cancer Incidence and Screening
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- Dietary Effects on Health
- Adolescent Sexual and Reproductive Health
- Mobile Health and mHealth Applications
- Viral gastroenteritis research and epidemiology
- AI in cancer detection
- Cancer Risks and Factors
- Medical Coding and Health Information
- Reproductive Health and Contraception
- Vitamin D Research Studies
- Menstrual Health and Disorders
- Hepatitis Viruses Studies and Epidemiology
- Health Sciences Research and Education
- Social Media in Health Education
- Nutrition, Health and Food Behavior
- Health Literacy and Information Accessibility
Kaiser Permanente Washington Health Research Institute
2023
Program for Appropriate Technology in Health
2018-2022
Sexual Health Clinic
2020
VillageReach
2020
Fred Hutch Cancer Center
2009-2019
Program for Appropriate Technology in Health
2019
Instituto Nacional de Enfermedades Neoplásicas
2018
National Cancer Institute
2011-2012
German Cancer Research Center
2012
Heidelberg University
2012
Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This particularly true postmenopausal women; a population with high prevalence toward whom fewer studies targeted. We conducted year-long, 4-arm randomized trial among 439 overweight-to-obese sedentary women to determine effects calorie-reduced, low-fat diet (D), moderate-intensity, facility-based aerobic exercise program (E), or combination both (D+E), vs. no-lifestyle-change...
Abstract Obese and sedentary persons have increased risk for cancer; inflammation is a hypothesized mechanism. We examined the effects of caloric restriction weight loss diet exercise on inflammatory biomarkers in 439 women. Overweight obese postmenopausal women were randomized to 1-year: (goal 10% loss, N = 118), aerobic (225 min/wk moderate-to-vigorous activity, 117), combined + (N or control 87). Baseline 1-year high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA),...
Abstract Background Although lifestyle interventions targeting multiple behaviors are more effective in preventing unhealthy weight gain and chronic diseases than intervening on a single behavior, few studies have compared individual combined effects of diet and/or exercise health-related quality life (HRQOL). In addition, the mechanisms how these affect HRQOL unknown. The primary aim this study was to examine dietary loss psychosocial factors (depression, anxiety, stress, social support)....
Estrogens and androgens are elevated in obesity associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated individual combined effects a reduced-calorie diet exercise serum sex hormones overweight obese women.We conducted single-blind, 12-month, randomized controlled trial from 2005 to 2009. Participants (age 50 75 years; body mass index > 25.0 kg/m(2), exercising < 100 minutes/wk) were randomly assigned using...
Abstract Background Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration adipose‐derived adiponectin leptin levels. We investigated effects 12‐month reduced calorie, loss exercise interventions on concentrations. Methods Overweight/obese postmenopausal women ( n = 439) were randomized as follows: (i)...
The Sabes Study evaluated a treatment-as-prevention intervention among cisgender men who have sex with and transgender women in Lima, Peru—populations disproportionately affected by the human immunodeficiency virus (HIV) epidemic. was designed to prevent onward transmission of HIV identifying HIV-negative high-risk individuals, testing them monthly for presence HIV, then rapidly treating those became HIV-positive. main outcome interest development model predicting population-level impact...
A questionnaire was mailed to 97,364 married women, aged 26--50, resident in Greater Boston 1970, requesting information on lifetime oral contraceptive (OC) use, reproductive history, education, and hospitalization experience 1969; 65,843 women responded. In 1973 a second 37,292 of these including all OC users an equal number non-users matched age, parity, town residence. This related use OCs, other female hormones, the menopause. most strongly with sixfold increase from oldest (of whom 10...
ABSTRACT INTRODUCTION Obese men have an increased risk of prostate cancer (PCa)‐specific mortality. Potential mechanisms include insulin and related proteins. We investigate whether a short‐term caloric restriction diet in overweight/obese with newly diagnosed PCa can lead to measurable changes patient anthropometrics insulin‐related METHODS Overweight obese patients choosing active surveillance or radical prostatectomy were randomized 6‐week, caloric‐restricted continue their current diet....
Abstract Background In addition to demonstrated public health benefits on reducing transmission, it remains unclear how early antiretroviral therapy (ART) must be started after acquisition of human immunodeficiency virus (HIV) maximize individual benefits. Methods We conducted an open-label randomized clinical study in Lima, Peru among adult men who have sex with and transgender women acute (HIV-antibody negative/HIV-1 RNA positive) or recent (confirmed negative HIV-antibody test within 3...
This report describes the breastfeeding and weaning practices of rural women in two Mexican towns cultural beliefs upon which these are based. Interviews focus group discussions were used to collect information. Women thought preferable bottle-feeding. Eighty percent initiated 69% gave colostrum. Breastfeeding was discontinued early (mean age 4 months). The mean at children introduced other liquids 2 months (range 0–5 months) solids, 1–8 Women's decisions regarding infant feeding influenced...
Late-stage breast cancer detection should be something of the past; however, it is still all too common in low-resource areas, including Peru, where 57% women diagnosed with are at stage III or IV disease. Early feasible semirural and rural areas mammography rarely accessible.PATH collaborated Peruvian health institutions local, regional, national levels to design implement a model care for early Peru. The includes training promoters community outreach, professional midwives clinical exam,...
<h3>ABSTRACT</h3> Scaling up coverage of routine cervical screening in low-resource settings must be accompanied by efforts to retain women throughout the cascade and continuum care, including adequate follow-up abnormal results. The Scale-Up Project implemented human papillomavirus (HPV) testing for cancer within public-sector health facilities Honduras between 2015 2019. Women who were HPV-positive but did not have visually confirmed lesions upon visual inspection with acetic acid...
To evaluate the diagnostic impact of point-of-care breast ultrasound by trained primary care physicians (PCPs) as part a cancer detection program using clinical exam in an underserved region Peru. Medical records and images symptomatic women presenting to Breast Cancer Detection Model (BCDM) Trujillo, Peru were collected from 2017–2018. Performance was measured against final outcomes derived regional center medical records, fine needle aspiration results, patient follow-up (sensitivity,...
Currently available live, oral rotavirus vaccines (LORVs) have significantly reduced severe hospitalizations and deaths worldwide. However, LORVs are not as effective in low- middle-income countries (LMIC) where disease burden is highest. Next-generation vaccine (NGRV) candidates development may a greater public health impact they needed most. The feasibility acceptability of possible new were explored part larger value proposition for injectable NGRVs LMICs.
For youth receiving care in community mental health centers, comorbidities are the rule rather than exception. Using measurement-based (MBC), or routine evaluation of symptoms to inform decisions, as foundation treatment for with comorbid problems significantly improves impact psychotherapy by focusing and building engagement alliance. MBC increases rate symptom improvement, detects clients who would otherwise deteriorate, alerts clinicians non-responders. Despite its demonstrated utility,...
A substantial body of literature has characterized how psychosocial factors, including HIV-related stigma and coping, are associated with HIV testing care utilization post-diagnosis. Less is known about if certain characteristics pre-diagnosis may also predict linkage to among individuals who receive an HIV-positive diagnosis. We examined awareness/perception dispositional coping styles predicted within three months post-diagnosis a secondary analysis 604 patients from randomized controlled...
This pilot study examines associations of perceived stigma pre-diagnosis with experienced and social support post-diagnosis qualitative data; quantifies the interplay between pre- factors on depressive symptoms among a sample newly diagnosed Peruvian men who have sex (n = 67 total). Qualitative findings highlight differences perceptions pre-disclosure actual experiences post-disclosure for most participants. Perceived was significantly related to support, B -0.35, p 0.03, marginally...
Background Live oral rotavirus vaccines (LORVs) have significantly reduced hospitalizations and deaths worldwide. However, LORVs are less effective in low- middle-income countries (LMICs). Next-generation (NGRVs) may be more but require administration by injection or a neonatal dose, adding operational complexity. Healthcare providers (HPs) were interviewed to assess vaccine preferences identify delivery issues as part of an NGRV value proposition. Objective Determine HP about delivering...