A5102809148- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Fluorine in Organic Chemistry
- HIV, Drug Use, Sexual Risk
- Organophosphorus compounds synthesis
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
- Phytochemicals and Medicinal Plants
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Ubiquitin and proteasome pathways
- Traditional and Medicinal Uses of Annonaceae
- Sex work and related issues
- RNA modifications and cancer
- HIV-related health complications and treatments
- Asymmetric Synthesis and Catalysis
- Adolescent Sexual and Reproductive Health
- Cancer Treatment and Pharmacology
- Amyotrophic Lateral Sclerosis Research
- interferon and immune responses
- Chemical Synthesis and Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
National University of San Marcos
2011-2022
Asociación Civil Impacta Salud y Educación
2021
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2020
Universidad Nacional Autónoma de México
1999-2008
BackgroundEarly antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment the HIV reservoir. However, effect early ART on long-term dynamics pool infected cells remains unclear.MethodsIn this longitudinal analysis, we included cisgender men who have sex with (MSM) and transgender women (aged 18–54 years) at high risk for infection, enrolled in ongoing MERLIN study Peru between Oct 28, 2014, Nov 8, 2018. Participants were eligible if they had been less...
Abstract Background In addition to demonstrated public health benefits on reducing transmission, it remains unclear how early antiretroviral therapy (ART) must be started after acquisition of human immunodeficiency virus (HIV) maximize individual benefits. Methods We conducted an open-label randomized clinical study in Lima, Peru among adult men who have sex with and transgender women acute (HIV-antibody negative/HIV-1 RNA positive) or recent (confirmed negative HIV-antibody test within 3...
Prior studies attempting to link biomarkers of immune activation with risk acquiring HIV have relied on cross sectional samples, most without proximity acquisition. We created a nested case-control study within the Sabes in Peru, and assessed panel plasma at enrollment longitudinally, including month diagnosis primary or matched timepoint controls. used machine learning select sociobehavioral covariates predictive Most were indistinguishable between cases controls one before diagnosis....
Abstract Reaction of Grignard reagents with diethyl cyanophosponate gave aryl phosphonates under mild conditions and in good yield
We assessed sexual behavior and incidence of sexually transmitted infections (STIs) among men who have sex with transgender women participating in Sabes, a study an expanded treatment as prevention strategy focused on early diagnosis HIV infection Lima, Peru (2013-2017).
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive degeneration of motor neurons in cerebral cortex and spinal cord, with rapid progression from diagnosis to death. The great majority ALS cases around 50% FTD present TDP-43 pathology, leading mislocalization cytoplasmic aggregation TDP-43, which can result both its loss nuclear functions gain toxicity cytoplasm. other RNA-binding proteins accumulate stress granules (SGs) under...
We investigated antitumor effect of aqueous extract Bomarea cornigera. Swiss albino mice strain were inoculated with tumor cell line TG-180 for 15 days, after which they separated into 5 groups (n= per group). Cyclophosphamide was administered intraperitoneally (positive control), distilled water (negative control) and the at concentrations 1X, 2X 4X; morbidity, mortality, weight length sarcoma assessed. found an inhibitory B. cornigera in development solid where transplanted. The inhibition...
Abstract Despite antiretroviral therapy (ART), HIV-1 persists in proliferating T cell clones that increase over time. To understand whether early ART affects persistence vivo , we performed single-cell ECCITE-seq and profiled 89,279 CD4 + cells paired samples during viremia after immediate versus delayed six people the randomized interventional Sabes study. We found partially reverted TNF responses while did not. Antigen persisted despite shaped transcriptional landscape of cells, RNA...
Abstract We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of the first 24 weeks after diagnosis untreated participants those who started antiretroviral therapy (ART) immediately at diagnosis. In absence treatment, viral was >1000 copies/mL almost all specimens (83%) collected 2–10 estimated date acquisition remained 35% last observed time point. Thus, ART, a level consistent with transmissibility throughout infection.
Background: There are few clinical trial data to inform recommendations about management of acute HIV. In addition the demonstrated public health benefits on reducing transmission, clinical, virologic and immunologic early treatment after HIV infection have been recognized, but optimal window maximize these remains unclear.Methods: Adult men who sex with transgender women (HIV-antibody negative/HIV-1 RNA positive) or recent (confirmed negative HIV-antibody test within three months)...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”