A5035071129- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Prostate Cancer Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Herpesvirus Infections and Treatments
- Adolescent Sexual and Reproductive Health
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Cannabis and Cannabinoid Research
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Minimally Invasive Surgical Techniques
- Animal Disease Management and Epidemiology
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
Case Western Reserve University
2020-2023
University Hospitals of Cleveland
2023
University School
2020-2022
Fred Hutch Cancer Center
2019-2021
Abstract Background In addition to demonstrated public health benefits on reducing transmission, it remains unclear how early antiretroviral therapy (ART) must be started after acquisition of human immunodeficiency virus (HIV) maximize individual benefits. Methods We conducted an open-label randomized clinical study in Lima, Peru among adult men who have sex with and transgender women acute (HIV-antibody negative/HIV-1 RNA positive) or recent (confirmed negative HIV-antibody test within 3...
Early systemic and central nervous system viral replication inflammation may affect brain integrity in people with HIV, leading to chronic cognitive symptoms not fully reversed by antiretroviral therapy (ART). This study examined associations between performance markers of CNS injury associated acute HIV infection ART.
Pharmacological HIV-1 reactivation to reverse latent infection has been extensively studied. However, also occurs naturally, as evidenced by occasional low-level viremia ("viral blips") during antiretroviral treatment (ART). Clarifying where blips originate from and how they happen could provide clues stimulate latency reversal more effectively safely or prevent viral rebound following ART cessation. We studied in the female genital tract, a dynamic anatomical target for throughout all...
medication-assisted treatment (MAT) with buprenorphine is now widely prescribed to treat addiction heroin and other illicit opioids. There some evidence that opioids enhance HIV-1 replication accelerate AIDS pathogenesis, but the effect of unknown.we obtained peripheral blood mononuclear cells (PBMCs) from healthy volunteers cultured them in presence morphine, buprenorphine, or methadone. We infected a replication-competent CCR5-tropic reporter virus encoding secreted nanoluciferase gene,...
Prior studies attempting to link biomarkers of immune activation with risk acquiring HIV have relied on cross sectional samples, most without proximity acquisition. We created a nested case-control study within the Sabes in Peru, and assessed panel plasma at enrollment longitudinally, including month diagnosis primary or matched timepoint controls. used machine learning select sociobehavioral covariates predictive Most were indistinguishable between cases controls one before diagnosis....
We evaluated the influence of 5-alpha reductase inhibitors (5-ARIs) on performance magnetic resonance imaging (MRI) for detection Gleason grade group (GG) ≥2 prostate cancer, and apparent diffusion coefficient (ADC) maps.This single center, retrospective study included men who had MRI initial or active surveillance cancer. The 59 used 5-ARIs ≥12 months, control were matched both indication biopsy results. DeLong's test was to compare area under receiver operating characteristic curve (AUC)...
Primary human immunodeficiency virus (HIV) is characterized by dynamic changes in viral load and innate adaptive immune responses; it unclear the extent to which time from acquisition antiretroviral therapy (ART) initiation substance use impact these immunologic changes.
You have accessJournal of UrologyPenile & Testicular Cancer: Penile Cancer II (PD53)1 Sep 2021PD53-12 RISKS OF PRIMARY ACTIVE SURVEILLANCE FOR SMALL TESTICULAR MASSES Danly Omil-Lima, Karishma Gupta, Irma Lengu, Rogelio Valdez, Nannan Thirumavalavan, and Kyle Scarberry Omil-LimaDanly Omil-Lima More articles by this author , GuptaKarishma Gupta LenguIrma Lengu ValdezRogelio Valdez ThirumavalavanNannan Thirumavalavan ScarberryKyle View All Author...
Background: There are few clinical trial data to inform recommendations about management of acute HIV. In addition the demonstrated public health benefits on reducing transmission, clinical, virologic and immunologic early treatment after HIV infection have been recognized, but optimal window maximize these remains unclear.Methods: Adult men who sex with transgender women (HIV-antibody negative/HIV-1 RNA positive) or recent (confirmed negative HIV-antibody test within three months)...
298 Background: We sought to identify PSA density (PSAD) and Prostate Imaging-Reporting Data Systems (PI-RADS) category cut-offs that would allow deferring biopsy in men with suspicion for clinically significant prostate cancer (csPCa). Methods: Our institution’s MRI registry (n = 1718) was queried patients who had MRI-guided (MRI-GB) and/or systematic (SB) performed after between January 2013 October 2018 676). Patients the diagnostic group (either naïve or prior negative biopsy) PCa on...
INTRODUCTION AND OBJECTIVE: We sought to identify PSA density (PSAD) and Prostate Imaging-Reporting Data Systems (PI-RADS) category cut-offs that would allow deferring biopsy in men with suspicion for clinically significant prostate cancer (csPCa). METHODS: Our institution’s MRI registry (n = 1718) was queried patients who had MRI-guided (MRI-GB) and/or systematic (SB) performed after between January 2013 October 2018 676). Patients the diagnostic group (either naïve or prior negative...