A5074227104- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Reproductive tract infections research
- Sex work and related issues
- Cervical Cancer and HPV Research
- HIV-related health complications and treatments
- Genital Health and Disease
- Syphilis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- LGBTQ Health, Identity, and Policy
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
Fred Hutch Cancer Center
2016-2025
University of Washington
2016-2025
University of Utah
2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2006-2023
Seattle University
2018-2021
Strategic Analysis (United States)
2020
Cancer Research Center
2011-2019
Uganda Cancer Institute
2016
University of North Carolina at Chapel Hill
2000-2015
Infectious Disease Research Institute
2011-2013
Human immunodeficiency virus (HIV) infection and related immunosuppression are associated with excess risk for cervical neoplasia human papillomavirus (HPV) persistence. Type-specific HPV was assessed at 6-month intervals HIV-positive HIV-negative women (median follow-up, 2.5 2.9 years, respectively). The type-specific incidence of determined, factors persistence were investigated by statistical methods that accounted repeated measurements. 1.8, 2.1, 2.7 times more likely to have high-,...
Objective To investigate the relationship between HIV seropositivity and bacterial vaginosis (BV) in a population at high risk for sexual acquisition of HIV. Design A cross-sectional study was conducted among 144 female commercial sex workers Chiang Mai, Thailand. Methods The participants were tested cervical gonorrhea Chlamydia infection, syphilis, Trichomonas vaginitis, Candida BV, infection. BV diagnosed by clinical criteria (pH>4.5, positive amine test, presence clue cells) using Gram...
Background: Human papillomavirus (HPV) type 16 is etiologically associated with approximately half of all cervical cancers. It important, therefore, to determine the characteristics that distinguish HPV16 from other HPV types. A preliminary result based on cross-sectional baseline data in Women's Interagency Immunodeficiency Virus (HIV) Study (WIHS) suggested prevalence might have a weaker association immune status HIV-seropositive women than To address this issue, we examined test results...
The Step Study tested whether an adenovirus serotype 5 (Ad5)-vectored human immunodeficiency virus (HIV) vaccine could prevent HIV acquisition and/or reduce viral load set-point after infection. At the first interim analysis, nonefficacy criteria were met. Vaccinations halted; participants unblinded. In post hoc analyses, more infections occurred in vaccinees vs placebo recipients men who had Ad5-neutralizing antibodies uncircumcised. Follow-up was extended to assess relative risk of over...
To better understand how innate immune responses to vaccination can lead lasting protective immunity, we used a systems approach define signatures in humans over 1 wk following MRKAd5/HIV that predicted subsequent HIV-specific T-cell responses. Within 24 h, striking increases peripheral blood mononuclear cell gene expression associated with inflammation, IFN response, and myeloid trafficking occurred, lymphocyte-specific transcripts decreased. These alterations were corroborated by marked...
Recombinant viruses hold promise as vectors for vaccines to prevent infectious diseases with significant global health impacts. One of their major limitations is that preexisting anti-vector neutralizing antibodies can reduce T cell responses the insert antigens; however, impact vector-specific cellular immunity on subsequent insert-specific has not been assessed in humans. Here, we have identified and compared adenovirus-specific HIV-specific subjects participating two HIV-1 vaccine trials...
We evaluated the association between HIV-1 RNA copies/mL in men and heterosexual transmission to their female partners among 493 couples Thailand. Husbands were identified as HIV-positive when they screened blood donors; nearly all infected with HIV subtype E. Wives had no known risks for infection other than sex husbands. In multivariate analysis, each log10 increment of man was associated an 81% increased rate his wife (odds ratio = 1.81, 95% confidence interval: 1.33-2.48). No occurred at...
We examined incidence and correlates of progression regression abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV)-seropositive 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive 34 (9%) had incident SILs detected by Pap test; 47 (7%) developed high-grade lesions. The was 11.5 cases among 2.6 per 100 person-years observation...
In April 2006, the National Institute of Allergy and Infectious Disease (NIAID)-funded HIV Vaccine Trials Network NIAID Division AIDS sponsored a workshop at which nonhuman primate (NHP) researchers clinical trial scientists with vaccine research expertise discussed how to more effectively use NHPs for evaluating HIV-1 candidates. This precipitated broad discussion on what types NHP studies should be targeted in critical preclinical pathway candidates, especially those designed elicit...
BackgroundEarly antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment the HIV reservoir. However, effect early ART on long-term dynamics pool infected cells remains unclear.MethodsIn this longitudinal analysis, we included cisgender men who have sex with (MSM) and transgender women (aged 18–54 years) at high risk for infection, enrolled in ongoing MERLIN study Peru between Oct 28, 2014, Nov 8, 2018. Participants were eligible if they had been less...
To determine the natural history of bacterial vaginosis in women with or at risk for human immunodeficiency virus (HIV).A cohort 854 HIV-infected and 434 HIV-uninfected from four US sites was followed prospectively gynecologic exams every 6 months over a 5-year period. The prevalence, incidence, persistence, severity vaginosis, which defined using Gram-staining scoring system, were calculated generalized estimating equation methods.In adjusted analyses, had higher prevalence than (adjusted...
Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain types, such as HPV16, may be more persistent than other HPV and type-specific persistence differ by HIV serostatus. This study evaluated the association between type clearance of infections in 522 HIV-seropositive 279 HIV-seronegative participants Epidemiology Research Study (HERS, United States, 1993-2000). Type-specific were detected using MY09/MY11/HMB01-based PCR 26 probes. The...