Participation in leisure activities has been associated with a lower risk of dementia. It is unclear whether increased participation lowers the dementia or declines during preclinical phase dementia.We examined relation between and prospective cohort 469 subjects older than 75 years age who resided community did not have at base line. We frequency enrollment derived cognitive-activity physical-activity scales which units measure were activity-days per week. Cox proportional-hazards analysis...

To better understand the duration of immunity against respiratory syncytial virus (RSV) and role serum antibodies to surface glycoproteins, F G, in susceptibility reinfection, 15 adults with previous natural RSV infection were challenged same strain group (A) at 2, 4, 8, 14, 20, 26 months after infection. By 2 about one-half by 8 two-thirds subjects became reinfected. Each challenge resulted least one-fourth subjects. Within 73% had two or more 47% three infections. The tended increase...

Neurologic abnormalities affecting gait occur early in several types of non-Alzheimer's dementias, but their value predicting the development dementia is uncertain.We analyzed relation between neurologic status at base line and a prospective study involving 422 subjects older than 75 years age who lived community did not have line. Cox proportional-hazards regression analysis was used to calculate hazard ratios with adjustment for potential confounding demographic, medical, cognitive...

Little is known in human immunodeficiency virus (HIV)-positive women about how the combination of plasma HIV RNA level and CD4+ T-cell count associated with natural history papillomavirus (HPV) infection or HPV reactivation--whether it occurs what frequency HIV-positive women.HIV-positive (n = 1848) -negative 514) were assessed at semiannual visits (total person-years 5661) for cervicovaginal polymerase chain reaction assays squamous intraepithelial lesions (SILs) by Pap smear. We studied...

OBJECTIVES: To study the epidemiology of gait disorders in community‐residing older adults and their association with death institutionalization. DESIGN: Community‐based cohort study. SETTING: Bronx County research center at Albert Einstein College Medicine. PARTICIPANTS: The Aging recruited 488 aged 70 to 99 between 1999 2001. At entry during annual visits over 5 years, subjects received clinical evaluations determine presence neurological or nonneurological abnormalities. MEASUREMENTS:...

OBJECTIVES: Although cognitive impairment is known to be a major risk factor for falls in older individuals, the role of tests predicting has not been established. Limited attentional resources may increase individuals. We examined reliability and validity divided attention tasks, walking while talking (WWT), falls. DESIGN: A prospective cohort study 12‐months' duration. SETTING: Community‐based longitudinal aging study, Einstein Aging Study. PARTICIPANTS: Sixty nondemented community‐living...

In the Baltimore Longitudinal Study of Aging (BLSA), we examined temporal unfolding declining performance on tests episodic memory (Free Recall Free and Cued Selective Reminding Test), executive function (Category Fluency, Letter Trails), Verbal Intelligence (Nelson, 1982; American Version Nelson Adult Reading Test [AMNART]) before diagnosis dementia in 92 subjects with incident Alzheimer's disease (AD) followed for up to 15 years diagnosis. To examine preclinical onset cognitive decline,...

This study examines the impact of yoga, including physical poses, breathing, and meditation exercises, on quality life (QOL), fatigue, distressed mood, spiritual well-being among a multiethnic sample breast cancer patients.One hundred twenty-eight patients (42% African American, 31% Hispanic) recruited from an urban center were randomly assigned (2:1 ratio) to 12-week yoga intervention (n = 84) or waitlist control group 44). Changes in QOL (eg, Functional Assessment Cancer Therapy) before...

<b>Objective: </b> To study the influence of leisure activity participation on risk development amnestic mild cognitive impairment (aMCI). <b>Methods: The authors examined relationship between baseline level in activities and aMCI a prospective cohort 437 community-residing subjects older than 75 years, initially free dementia or aMCI, using Cox analysis adjusted for age, sex, education, chronic illnesses. derived Cognitive Physical Activity Scales based frequency individual activities....

Journal Article Occurrence of Groups A and B Respiratory Syncytial Virus over 15 Years: Associated Epidemiologic Clinical Characteristics in Hospitalized Ambulatory Children Get access Caroline Breese Hall, Hall From the Departments Pediatrics Medicine, University Rochester School Medicine Dentistry, Praxis Biologics, Rochester, New York; Division Viral Diseases, Center for Infectious Disease, Centers Disease Control, Atlanta, Georgia Correspondence: Dr. Box 689, 601 Elmwood Ave., NY 14642....

As the population ages, need to characterize rates of cognitive impairment and dementia within demographic groups defined by age, sex, race becomes increasingly important. There are limited data available on prevalence incidence amnestic mild (aMCI) nonamnestic (naMCI) from population-based studies. The Einstein Aging Study, a systematically recruited community-based cohort 1944 adults aged 70 or older (1168 free at baseline; mean 78.8 y; average follow-up, 3.9 y), provides opportunity...

Persons destined to develop dementia experience an accelerated rate of decline in cognitive ability, particularly memory. Early life education and participation cognitively stimulating leisure activities later are 2 factors thought reflect reserve, which may delay the onset memory preclinical stages dementia.We followed 488 initially intact community residing individuals with epidemiologic, clinical, assessments every 12 18 months Bronx Aging Study. We assessed influence self-reported on as...

<h3>Importance</h3> Risk factors for out-of-hospital death due to novel coronavirus disease 2019 (COVID-19) are poorly defined. From March 1 April 25, 2020, New York City, (NYC), reported 17 118 COVID-19–related deaths. On 6, cardiac arrests peaked at 305 cases, nearly a 10-fold increase from the prior year. <h3>Objective</h3> To describe characteristics (race/ethnicity, comorbidities, and emergency medical services [EMS] response) associated with outpatient during COVID-19 pandemic in NYC....

Background. Influenza vaccines may be reformulated annually because of antigenic drift in influenza viruses. However, the relationship between characteristics circulating viruses and vaccine effectiveness (VE) is not well understood. We conducted an assessment US during 2010–2011 season. Methods. performed a case–control study comparing vaccination histories subjects with acute respiratory illness positive real-time reverse transcription polymerase chain reaction for test-negative controls....

The level of body-mass index (BMI) associated with the lowest risk death remains unclear. Although differences in muscle mass limit utility BMI as a measure adiposity, no study has directly examined effect on BMI-mortality relationship.Body composition was measured by dual-energy x-ray absorptiometry 11,687 participants National Health and Nutrition Examination Survey 1999-2004. Low defined using sex-specific thresholds appendicular skeletal (ASMI). Proportional hazards models were created...

To estimate the relative rates of dementia in initially nondemented subjects with and without memory impairment defined by baseline free recall from Free Cued Selective Reminding (FCSR) test.Our approach to identifying persons at high risk for future is show presence not caused other cognitive deficits using a test that controls attention processing. When conditions testing are adequately controlled, prediction reduced because age-associated due confused dementia-associated...

The emergence of influenza A viruses which had acquired resistance to rimantadine during a clinical trial (C. B. Hall, R. Dolin, C. L. Gala, D. M. Markovitz, Y. Q. Zhang, P. H. Madore, F. A. Disney, W. Talpey, J. Green, Francis, and E. Pichichero, Pediatrics 80:275-282, 1987) provided the opportunity determine genetic basis this phenomenon. Analysis reassortant generated with resistant isolate (H3N2) susceptible A/Singapore/57 (H2N2) virus indicated that RNA segment 7 coding for matrix M2...

We present a case of 29-year-old woman who presented to volunteer-run primary care facility in Southern Belize. Her initial presentation was vaginal itching and white discharge; she also requested insertion sub-dermal contraceptive implant. During the insertion, marks suspicious for deliberate self-harm were noticed on patient's arm, further exploration revealed being physically emotionally abused by her husband. With some encouragement, help taking action preserve safety; however, Belize...

The relationship between abnormal cell proliferation and aberrant control of hormonal secretion is a fundamental poorly understood issue in endocrine neoplasia. Transgenic mice with parathyroid-targeted overexpression the cyclin D1 oncogene, modeling gene rearrangement found human tumors, were created to determine whether primary defect this cell-cycle regulator can cause an serum calcium parathyroid hormone response, as typical hyperparathyroidism. We also sought develop animal model...

To understand the transmission of respiratory syncytial virus, we examined frequency infection in volunteers after inoculation by different routes with varying doses virus. Thirty-two adult received serial dilutions a safety-tested live strain virus instilled into nose, eye, or mouth. The highest inoculum, 5.2 log10 50% tissue culture infective dose (TCID50), was administered to four groups subjects each, nose one group, eye and mouth two groups. Subsequently, 1:100 1:1,000 this inoculum...

<b>Objective: </b> To explore the relationship of seizure occurrence with candidate precipitants in a prospective diary study, and to determine self-prediction. <b>Methods: Eligible subjects were 18 or older, had localization-related epilepsy, at least one within 12 months, able maintain daily diary. Information collected included occurrence, time characteristics all seizures, hours sleep, medication compliance, stress, anxiety, alcohol use, menstruation, Each night, reported their estimate...

Human herpesvirus 6 (HHV-6) causes a febrile illness in children and has been implicated as cause of encephalitis recurrent seizures. Paired samples cerebrospinal fluid (CSF) peripheral blood mononuclear cells (PBMC) from 487 were evaluated by nested polymerase chain reaction (PCR) for evidence current or past infection with HHV-6. PBMC also cultured isolation These data correlated the patients' clinical information. HHV-6 DNA was detected 72 (14.8%) CSF samples. persistence documented 142...