A5089957149- HIV Research and Treatment
- Viral-associated cancers and disorders
- HIV/AIDS Research and Interventions
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Menstrual Health and Disorders
- Cytomegalovirus and herpesvirus research
- Reproductive tract infections research
- HIV-related health complications and treatments
- Palliative Care and End-of-Life Issues
- SARS-CoV-2 and COVID-19 Research
- Economic and Financial Impacts of Cancer
- HIV, Drug Use, Sexual Risk
- Advanced Biosensing Techniques and Applications
- Energy and Environment Impacts
- Animal Disease Management and Epidemiology
- Extracellular vesicles in disease
- Sex work and related issues
- Hematopoietic Stem Cell Transplantation
- Syphilis Diagnosis and Treatment
University of Washington
2019-2024
Fred Hutch Cancer Center
2020-2024
The University of Texas Southwestern Medical Center
2023-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2020
Cancer Research Center
2020
University of Luxembourg
2017
ABSTRACT Background Increasing evidence connects the gut microbiota and onset and/or phenotype of Parkinson's disease (PD). Differences in abundances specific bacterial taxa have been reported PD patients. It is, however, unknown whether these differences can be observed individuals at high risk, for example, with idiopathic rapid eye movement sleep behavior disorder, a prodromal condition α‐synuclein aggregation disorders including PD. Objectives To compare carefully preserved nasal wash...
To assess whether biomarkers of systemic inflammation are associated with HIV acquisition or the timing ART initiation (“immediate”, at diagnosis, versus “deferred”, 24 weeks post-diagnosis) in men-who-have-sex-with-men (MSM) and transgender women, we conducted a retrospective study comparing inflammatory participants’ specimens collected before infection after ≥2 years effective ART. We measured four longitudinally plasma, including two from each participant confirmed ART-suppression....
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants clonal expansion remain poorly understood. We performed sequencing at >4,000x depth coverage for CHIP mutations in 6,986 postmenopausal women from Women’s Health Initiative two timepoints approximately 15 years apart. Among 3,685 detected baseline (VAF ≥ 0.5%), 50% progressed to 2%) follow-up. confirmed that highly dependent on initial clone size...
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment prevention. Previously, we found that topical rectal tenofovir gel caused immunological changes in the mucosa. Here, assess effect of oral TDF/FTC three pre-exposure prophylaxis trials, two with gastrointestinal one cervicovaginal biopsies. induces type I/III interferon-related (IFN I/III) genes tract, but not blood, strong correlations between independent biopsy groups (Spearman r = 0.91) rectum duodenum...
Sexual Zika virus (ZIKV) transmission from men to women occurs less frequently than the often-detected high viral loads in semen would suggest, but worries that this route predisposes fetal damage pregnant remain. To better understand sexual ZIKV pathogenesis, we studied permissiveness of human female genital tract infection and effect on process. replicates vaginal tissues primary epithelial cells vagina, ectocervix, endocervix induces an innate immune response, also continues replicate...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrates the need for accurate and convenient approaches to diagnose therapeutically monitor viral infections. We demonstrated that self-sampling with mid-nasal foam swabs is well-tolerated provides quantitative output concordant flocked swabs. Using longitudinal home-based self-sampling, we demonstrate nasal cytokine levels correlate cluster according immune cell of origin. Periods stable loads are followed by...
Pharmacological HIV-1 reactivation to reverse latent infection has been extensively studied. However, also occurs naturally, as evidenced by occasional low-level viremia ("viral blips") during antiretroviral treatment (ART). Clarifying where blips originate from and how they happen could provide clues stimulate latency reversal more effectively safely or prevent viral rebound following ART cessation. We studied in the female genital tract, a dynamic anatomical target for throughout all...
Changes in sex hormones during the menstrual cycle and contraceptive vaginal ring (CVR) use influence immunity within female genital tract, but magnitude of these effects their anatomical location are unclear.In a prospective study, 29 women were assessed at three-time points: follicular phase, luteal one month after initiation ethinyl estradiol/etonogestrel CVR (NuvaRing®, Merck). We performed microarrays on endocervical cytobrushes measured immune mediators cervicovaginal fluid, adjusting...
medication-assisted treatment (MAT) with buprenorphine is now widely prescribed to treat addiction heroin and other illicit opioids. There some evidence that opioids enhance HIV-1 replication accelerate AIDS pathogenesis, but the effect of unknown.we obtained peripheral blood mononuclear cells (PBMCs) from healthy volunteers cultured them in presence morphine, buprenorphine, or methadone. We infected a replication-competent CCR5-tropic reporter virus encoding secreted nanoluciferase gene,...
Prior studies attempting to link biomarkers of immune activation with risk acquiring HIV have relied on cross sectional samples, most without proximity acquisition. We created a nested case-control study within the Sabes in Peru, and assessed panel plasma at enrollment longitudinally, including month diagnosis primary or matched timepoint controls. used machine learning select sociobehavioral covariates predictive Most were indistinguishable between cases controls one before diagnosis....
Abstract Background The HIV reservoir of latently infected CD4+ T cells represents the barrier to cure. T-cell proliferation is a mechanism that sustains even during prolonged antiretroviral therapy (ART). Blocking may therefore deplete reservoir. Methods We conducted an unblinded, uncontrolled clinical trial mycophenolate, antiproliferative compound, in people with on chronic suppressive ART. Study drug dose selection was based calibration observed ex vivo effect. primary outcome clinically...
ABSTRACT Objective Assess whether biomarkers of systemic inflammation are associated with HIV acquisition or the timing ART initiation (“immediate”, at diagnosis, versus “deferred”, 24 weeks postdiagnosis) in men-who-have-sex-with-men (MSM) and transgender women. Design A retrospective study comparing inflammatory participants’ specimens collected before after ≥2 years effective ART. Methods Inflammatory were measured four longitudinally plasma specimens, including two from each participant...
Abstract The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to diagnose therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with foam swabs is well-tolerated provides quantitative output concordant flocked swabs. Using longitudinal home-based self-sampling, we demonstrate nasal cytokine levels correlate cluster according immune cell of origin. Periods stable loads are followed by rapid elimination, which could be coupled...
To study the influence of Affordable Care Act (ACA) policy and its Medicaid expansion on insurance status survival in patients with HIV aggressive lymphoma.
Rituximab and prednisone are commonly used treatments for autoimmune hemolytic anemia (AIHA), where the body's immune system attacks destroys its red blood cells. However, some AIHA patients may become refractory to rituximab treatment, this can result in continued hemolysis persistent anemia, making it challenging affected individuals manage their symptoms. The underlying causes of refractoriness be complex vary from patient patient. Herein, we present a case newly diagnosed warm cold that...
Abstract Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment prevention. Previously, we found that topical rectal tenofovir gel caused immunological changes in the mucosa. Here assessed effect of oral TDF/FTC three pre-exposure prophylaxis trials, two with gastrointestinal one cervicovaginal biopsies. induced type I/III interferon-related (IFN I/III) genes tract, but not blood, strong correlations between independent biopsy groups (Spearman r=0.91) rectum...
12129 Background: Palliative care benefits have been widely studied in solid tumors with early palliative demonstrating prolonged survival several malignancies including lung and esophageal cancer. There are limited data guidelines for use of hematopoietic stem cell transplants (HSCT). Methods: We used the National cancer database (NCDB) to identify HSCT recipients between 2004 2017 retrospectively examined outcomes based on receipt care. Chi-square Wilcoxon tests were compare categorical...
7032 Background: Previous smaller studies suggest that despite younger age at presentation, Hispanic patients (HP) with acute myeloid leukemia (AML) have worse prognosis than non-Hispanics (NHP). Methods: We queried the National Cancer Database (NCDB) between 2004 to 2017 for adults aged ≥18 years a diagnosis of AML using ICD-O-3 code. Baseline characteristics and outcomes were compared. Results: A total 144,146 identified during study period which 9173 (6.4%). The median was 66 overall....
90 Background: Cancer survivors often require home care services, but accessibility barriers prevent many patients and partners from harnessing their full benefit. We sought to characterize services use among cancer in the United States. Methods: identified with without history of 2016 2019 nationally representative Medical Expenditure Panel Survey (MEPS). extracted sociodemographics clinical characteristics. constructed a composite measure being eligible for if they reported any one three...
Sexual Zika virus (ZIKV) transmission from men to women occurs less frequently than the often-detected high viral loads in semen would suggest, but worries that this route predisposes fetal damage pregnant remain. To better understand sexual ZIKV pathogenesis, we studied permissiveness of human female genital tract infection and effect on process. replicates vaginal tissues primary epithelial cells vagina, ectocervix endocervix induces an innate immune response, also continues replicate...