A5020300004- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Motor Control and Adaptation
- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Muscle activation and electromyography studies
- HIV-related health complications and treatments
- Action Observation and Synchronization
- Tactile and Sensory Interactions
- Multisensory perception and integration
- Sex work and related issues
- Virus-based gene therapy research
- Emergency and Acute Care Studies
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- Balance, Gait, and Falls Prevention
- Nail Diseases and Treatments
- Hemispheric Asymmetry in Neuroscience
- Neuroscience and Music Perception
- Autoimmune and Inflammatory Disorders
- Immune Cell Function and Interaction
- Phonetics and Phonology Research
- Cervical Cancer and HPV Research
Fred Hutch Cancer Center
2018-2025
Harris Health System
2015-2020
Rice University
2020
Baylor College of Medicine
2019
University of Minnesota
2005-2011
The University of Texas Health Science Center at Houston
2010
Twin Cities Orthopedics
2008
University of Minnesota, Duluth
2005
A compelling example of auditory–visual multisensory integration is the McGurk effect, in which an auditory syllable perceived very differently depending on whether it accompanied by a visual movie speaker pronouncing same or different, incongruent syllable. Anatomical and physiological studies human nonhuman primates have suggested that superior temporal sulcus (STS) involved for both speech nonspeech stimuli. We hypothesized STS plays critical role creation percept. Because location varies...
Abstract Functional neuroimaging studies have implicated a number of brain regions, especially the posterior parietal cortex (PPC), as being potentially important for visual–tactile multisensory integration. However, are correlational and do not prove necessity region behavioral improvements that hallmark To remedy this knowledge gap, we interrupted activity in PPC, near junction anterior intraparietal sulcus postcentral sulcus, using MRI‐guided transcranial magnetic stimulation (TMS) while...
Encoding of movement kinematics in Purkinje cell simple spike discharge has important implications for hypotheses cerebellar cortical function. Several outstanding questions remain regarding representation these kinematic signals. It is uncertain whether encoding occurs unpredictable, feedback-dependent tasks or signals are conserved across tasks. Additionally, there a need to understand the encoded instantaneous single cells without averaging trials time. To address questions, this study...
The cerebellum plays an essential role in pursuit tracking with the eye and hand. During smooth movements, both position velocity are signaled by Purkinje cells. cell simple spike discharge is also modulated direction speed during linear manual tracking. This study evaluated how all three parameters, position, movement direction, speed, of cells circular Three rhesus monkeys intercepted then tracked a target moving circle counterclockwise clockwise directions across range constant speeds....
The Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe (DREAMS) Initiative aims to reduce HIV infections among adolescent girls young women (AGYW) in Africa. Oral pre-exposure prophylaxis (PrEP) is offered through DREAMS Kenya eligible AGYW high burden counties including Kisumu Homa Bay. This study examines PrEP persistence community-based delivery settings. We evaluated the program Bay using survival analysis programmatic refill data collected between March December 2017. Among...
Background: The Routine Universal Screening for HIV program provides opt-out testing and linkage to care emergency department (ED) patients in Harris Health System, Houston, TX. Seventy-five percent of positive this have been previously diagnosed. Whether is increased among these unknown. Methods: We conducted a retrospective cohort study persons tested the ED between 2008 2012 but had documented test ≥1 year prior. Outcomes were engagement (≥1 outpatient visits 6 months), retention (≥2 12...
Persistent infection with human papillomavirus (HPV) is associated most cervical and anal cancer cases a large fraction of other anogenital oropharyngeal cancers. The prophylactic HPV vaccines are known to prevent infections HPV-associated disease, although there evidence reduced response the vaccination among individuals living HIV. Prior studies without HIV suggest that single vaccine dose induces humoral immune responses that, while lower than those induced by two or three doses, still...
Objectives: To describe the prevalence of acute retroviral syndrome (ARS) and associated findings during primary HIV, explore relationship ARS to clinical, virological, immunological outcomes within a longitudinal screen, retest treat study that minimized ascertainment bias. Design: We evaluated symptoms signs among 216 persons with early incident HIV Sabes timing antiretroviral therapy (ART) initiation in Peru. Methods: patient reported used logistic regression generalized linear models...
Early systemic and central nervous system viral replication inflammation may affect brain integrity in people with HIV, leading to chronic cognitive symptoms not fully reversed by antiretroviral therapy (ART). This study examined associations between performance markers of CNS injury associated acute HIV infection ART.
Skin and soft tissue infections (SSTIs) disproportionately impact patients with human immunodeficiency virus (HIV). Recent declines in the incidence of SSTIs have been noted non-HIV population. We sought to study epidemiology microbiology a population 8597 followed for HIV primary care large, urban county system from January 2009 December 2014.SSTIs were identified electronic medical record by use International Classification Diseases-9 billing codes. Charts reviewed confirm each patient's...
Prior studies attempting to link biomarkers of immune activation with risk acquiring HIV have relied on cross sectional samples, most without proximity acquisition. We created a nested case-control study within the Sabes in Peru, and assessed panel plasma at enrollment longitudinally, including month diagnosis primary or matched timepoint controls. used machine learning select sociobehavioral covariates predictive Most were indistinguishable between cases controls one before diagnosis....
A substantial body of literature has characterized how psychosocial factors, including HIV-related stigma and coping, are associated with HIV testing care utilization post-diagnosis. Less is known about if certain characteristics pre-diagnosis may also predict linkage to among individuals who receive an HIV-positive diagnosis. We examined awareness/perception dispositional coping styles predicted within three months post-diagnosis a secondary analysis 604 patients from randomized controlled...
Early HIV detection and treatment decreases morbidity mortality reduces high-risk behaviors. Many Emergency Departments (EDs) have screening programs as recommended by the Centers for Disease Control Prevention. Recent federal legislation includes incentives electronic health record (EHR) adoption. Our objective was to analyze impact of conversion EHR on a mature ED-based program. A retrospective pre- post-EHR implementation cohort study conducted in large urban, academic ED. Medical records...
Abstract Despite antiretroviral therapy (ART), HIV-1 persists in proliferating T cell clones that increase over time. To understand whether early ART affects persistence vivo , we performed single-cell ECCITE-seq and profiled 89,279 CD4 + cells paired samples during viremia after immediate versus delayed six people the randomized interventional Sabes study. We found partially reverted TNF responses while did not. Antigen persisted despite shaped transcriptional landscape of cells, RNA...
In Lima, Perú, HIV prevalence is estimated to be 15% among men who have sex with (MSM) and 30% transgender women (TW). We investigated timely linkage of MSM TW care, as antiretroviral therapy (ART) critical protect the health those living prevent onward transmission. within 90 days diagnosis by matching data from two studies conducted in Lima between 2013 2015 national ART program records. used generalized linear modeling assess predictors late presentation care. Of 487 newly-diagnosed TW,...