A5101608773- Cytokine Signaling Pathways and Interactions
- Chromium effects and bioremediation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Gastroesophageal reflux and treatments
- IL-33, ST2, and ILC Pathways
- Advanced Radiotherapy Techniques
- Heart Rate Variability and Autonomic Control
- ATP Synthase and ATPases Research
- Alcoholism and Thiamine Deficiency
- Melanoma and MAPK Pathways
- Cardiac Fibrosis and Remodeling
- Fluorine in Organic Chemistry
- Gene expression and cancer classification
- Chronic Myeloid Leukemia Treatments
- Respiratory and Cough-Related Research
- Photosynthetic Processes and Mechanisms
- NF-κB Signaling Pathways
- COVID-19 Clinical Research Studies
- Phytochemistry and Bioactive Compounds
- Adsorption and biosorption for pollutant removal
- Quinazolinone synthesis and applications
- Bone health and treatments
- Chronic Lymphocytic Leukemia Research
- Various Chemistry Research Topics
Cedars-Sinai Medical Center
2023
Cedars-Sinai Smidt Heart Institute
2023
Stanford University
2005-2012
National Heart Lung and Blood Institute
2009
Citigroup
2005
University of Alabama
2004
Baylor University
2003
Herein we report the discovery of C-2 methyl substituted imidazopyrrolopyridine series and its optimization to provide potent orally bioavailable JAK1 inhibitors with selectivity over JAK2. The inhibitor 4 exhibited not only improved potency relative unsubstituted compound 3 but also notable vs JAK2 (20-fold >33-fold in biochemical cell-based assays, respectively). Features X-ray structures complex both are delineated. Efforts improve vitro vivo ADME properties while maintaining described,...
We tested the hypothesis that a set of differentially expressed genes could be used to classify mice according cardiovascular phenotype after prolonged catecholamine stress.Prospective, randomized study.University-based research laboratory.One hundred seventy-three male were studied: wild-type (WT) C57, WT FVB, B6129SF2/J, and beta2 adrenergic receptor knockout.Mice each genotype randomly assigned 14-day infusions isoproterenol (120 microg/g/day) or no treatment. Approximately half animals...
Members of the JAK family protein kinases mediate signal transduction from cytokine receptors to transcription factor activation. Over-stimulation these pathways is causative in immune disorders like rheumatoid arthritis, psoriasis, lupus, and Crohn's disease. A search for selective inhibitors a kinase has led our characterization previously unknown conformation arising presentation Tyr962 TYK2 an inhibitory small molecule via H-bonding interaction. minority domains Tyrosine residue this...
Abstract Background Tixagevimab−cilgavimab (Tix‐Cil) was authorized for prophylaxis against COVID‐19 in immunocompromised patients from December 2021 through January 2023. Real‐world effectiveness solid organ transplant (SOT) recipients has been unclear. Methods We enrolled 911 SOT into a longitudinal serology study, of whom 381 (42%) received ≥1 dose Tix‐Cil. collected and analyzed data on incident SARS‐CoV‐2 infections antibody kinetics all 2022 to March 2023, including periods dominated...
<b><i>Background:</i></b> In humans, methane (CH<sub>4</sub>) is exclusively produced by the intestinal microbiota and has been implicated in several conditions including cardiovascular disease. After microbial production of CH<sub>4</sub> gut, it steadily crosses into systemic circulation reaches lungs where can be detected exhaled breath, as a surrogate measure for production. Recent reports have shown an association between vagal dysfunction...
Abstract TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines, including Type I IFNs, IL-6, IL-10, and IL-12/23. Genetic mutation at the tyk2 locus has been linked broad-range immune deficiency dysregulation human patient, however murine strains that lack expression, only select pathways are compromised. We have utilized panel of TYK2-selective small molecule inhibitors with varying degrees selectivity against other kinases address requirement for...
Chang, Christine N; Hwang, Helen; Samad, Tamina F; Perry, Elise; Hawrylyshyn, Ashley; Agrawal, Rani; Patterson, Andrew J; Bruss, Matt; Conti, Marco Author Information