John Sasso

ORCID: 0000-0003-3395-2836
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About
Contact & Profiles
Research Areas
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cardiovascular and exercise physiology
  • Heart Rate Variability and Autonomic Control
  • Cancer survivorship and care
  • Respiratory Support and Mechanisms
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Function and Risk Factors
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Childhood Cancer Survivors' Quality of Life
  • Cardiovascular Effects of Exercise
  • Cardiac, Anesthesia and Surgical Outcomes
  • Diverse Approaches in Healthcare and Education Studies
  • Academic Writing and Publishing
  • Cardiac Health and Mental Health
  • Hemodynamic Monitoring and Therapy
  • Pulmonary Hypertension Research and Treatments
  • Exercise and Physiological Responses
  • Education and Learning Interventions
  • Lymphatic System and Diseases
  • Education, Safety, and Science Studies
  • Medication Adherence and Compliance
  • Asthma and respiratory diseases
  • Lung Cancer Diagnosis and Treatment

University of British Columbia
2017-2024

Okanagan University College
2018-2024

Kelowna General Hospital
2019

Memorial Sloan Kettering Cancer Center
2015-2016

BACKGROUND The investigation of exercise training in metastatic breast cancer has received minimal attention. This study determined the feasibility and safety aerobic cancer. METHODS Sixty‐five women (age, 21‐80 years) with (stage IV) (57% were receiving chemotherapy, >40% had ≥ 2 lines prior therapy) allocated to an group (n = 33) or a stretching 32). Aerobic consisted 36 supervised treadmill walking sessions delivered thrice weekly between 55% 80% peak oxygen consumption (VO 2peak ) for...

10.1002/cncr.31368 article EN Cancer 2018-04-06

The purpose of this study was to explore whether methods adapted from oncology pharmacological trials have utility in reporting adherence (tolerability) exercise treatment cancer.Using a retrospective analysis randomized trial, 25 prostate cancer patients received an aerobic training regimen 72 supervised treadmill walking sessions delivered thrice weekly between 55% and 100% capacity for 24 consecutive weeks. Treatment assessed using conventional (lost follow-up attendance) exploratory...

10.1249/mss.0000000000001545 article EN Medicine & Science in Sports & Exercise 2018-01-10

Abstract Aims The most appropriate timing of exercise therapy to improve cardiorespiratory fitness (CRF) among patients initiating chemotherapy is not known. effects administered during, following, or during and following were examined in with breast cancer. Methods results Using a parallel-group randomized trial design, 158 inactive women cancer (neo)adjuvant allocated receive (1:1 ratio): usual care one three regimens—concurrent (during only), sequential (after concurrent (continuous) (n =...

10.1093/eurheartj/ehad085 article EN European Heart Journal 2023-02-21

Skeletal muscle atrophy, dysfunction, and fatigue are important complications of chronic obstructive pulmonary disease (COPD). Greater reliance on glycolytic metabolism increased type III/IV afferent activity increase ventilatory drive, promote constraint, amplify exertional dyspnea, limit exercise tolerance. To investigate whether muscular adaptation with resistance training (RT) could improve tolerance, intrinsic neuromuscular fatigability in individuals COPD (n = 14, FEV1 62 ± 21%...

10.1152/japplphysiol.00303.2022 article EN Journal of Applied Physiology 2023-03-09

Exercise limitation in chronic obstructive pulmonary disease (COPD) is commonly attributed to abnormal ventilatory mechanics and/or skeletal muscle function, while cardiovascular contributions remain relatively understudied. To date, the integrative exercise responses associated with different cardiopulmonary phenotypes COPD have not been explored but may provide novel therapeutic utility. This study determined ventilatory, cardiovascular, and metabolic incremental patients...

10.3389/fphys.2022.816586 article EN cc-by Frontiers in Physiology 2022-02-15

Historically, undergraduate programs in Health and Exercise Sciences (i.e. Kinesiology) are rooted common areas such as physiology, anatomy, biomechanics, motor control, psychology, nutrition, rehabilitation. A typical four-year program offers a general education across these often delivering breadth of knowledge many areas, albeit lacking transferable technical skill that relates to industry. With graduates now pursuing advanced training professional there is need develop more...

10.1152/physiol.2024.39.s1.2243 article EN Physiology 2024-05-01

ABSTRACT Purpose Research on intermittent training has mainly focused the effects of exercise intensity while overlooking specific impact modulations associated with alternating and recovery. This study investigated how frequency during moderate-intensity affects post-exercise vagal reactivation. Methods Healthy, active females males aged 18-39 years were recruited for study. Participants completed three treadmill running sessions separate days. Each session accumulated 30 min at 90% second...

10.1249/mss.0000000000003580 article EN Medicine & Science in Sports & Exercise 2024-10-17

ABSTRACT Purpose The purpose of this study is to evaluate the prevalence abnormal cardiopulmonary responses exercise and pathophysiological mechanism(s) underpinning intolerance across continuum breast cancer (BC) care from diagnosis metastatic disease. Methods Individual participant data four randomized trials spanning BC ([1] prechemotherapy [ n = 146], [2] immediately postchemotherapy 48], [3] survivorship 138], [4] 47]) were pooled compared with women at high-risk (BC risk; 64)....

10.1249/mss.0000000000003348 article EN Medicine & Science in Sports & Exercise 2023-11-27

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTNotes on preparing a manuscript for publicationJohn Sasso Cite this: J. Chem. Educ. 1943, 20, 11, 540Publication Date (Print):November 1, 1943Publication History Received3 August 2009Published online1 November 1943Published inissue 1 1943https://doi.org/10.1021/ed020p540RIGHTS & PERMISSIONSArticle Views25Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since 2008 (both PDF and...

10.1021/ed020p540 article EN Journal of Chemical Education 1943-11-01

Augmented negative intrathoracic pressures (nITP) and dynamic hyperinflation (DH) are adverse breathing mechanics (ABM) associated with chronic obstructive pulmonary disease (COPD) that attenuate left ventricular (LV) preload augment afterload. In COPD, hypertension (elevated systemic arterial load) commonly adds additional afterload to the LV. Combined ABM may profoundly challenge ventricular-vascular coupling stroke volume (SV), particularly if LV systolic reserve is limited. However, even...

10.1152/japplphysiol.00833.2020 article EN Journal of Applied Physiology 2021-02-11

The aim of the current study was to investigate factors contributing exertional dyspnea in individuals who received thoracic surgery with curative intent for non-small cell lung cancer (NSCLC). It hypothesized that greater neuromechanical uncoupling (NMU: an imbalance between ventilatory effort and output) would result exercise intolerance NSCLC. Using a cross-sectional design, postsurgical NSCLC patients (n=22) performed pulmonary function test, incremental cycling cardiopulmonary test...

10.1183/13993003.congress-2019.pa765 article EN 01.05 - Clinical respiratory physiology, exercise and functional imaging 2019-09-28
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