A5066961889- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Birth, Development, and Health
- Lipid Membrane Structure and Behavior
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Herpesvirus Infections and Treatments
- Amyotrophic Lateral Sclerosis Research
- Dermatologic Treatments and Research
- Nanopore and Nanochannel Transport Studies
- Ginger and Zingiberaceae research
- Systemic Sclerosis and Related Diseases
- Renal Transplantation Outcomes and Treatments
- Dietary Effects on Health
- Intensive Care Unit Cognitive Disorders
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Phagocytosis and Immune Regulation
- Biochemical Acid Research Studies
- Research on Leishmaniasis Studies
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 and Mental Health
- Microfluidic and Bio-sensing Technologies
McMaster University
2021-2025
McMaster University Medical Centre
2019-2024
Background Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they associated the development of clinically relevant Post-Acute Sequalae COVID-19 (PASC) symptoms. Methods A rapid assessment line immunoassay was used measure circulating levels ANA/ENAs 106 convalescent varying acute phase severities at 3, 6, 12 months post-recovery. Patient-reported...
Most currently available vaccines, particularly live require the cold chain, as vaccine efficacy can be significantly hampered if they are not stored in a temperature range of 2-8 °C at all times. This necessity places tremendous financial and logistical burden on vaccination programs, developing world. The development thermally stable vaccines greatly alleviate this problem and, turn, increase accessibility worldwide. In paper, we detail simple cost-effective method for stabilizing that...
<title>Abstract</title> While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated impact of common, acute prior to onset on ALS progression in SOD1G93A mouse model. A single sublethal infection clinical signs was markedly accelerated characterized by rapid loss hindlimb function. Prior resulted gliosis lumbar spine and upregulation...
Survivors of severe SARS-CoV-2 infections frequently suffer from a range post-infection sequelae. Whether survivors mild or asymptomatic can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype function in individuals who had recovered (
Novel therapeutic strategies are needed to control the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. Here, we present a protocol anchor spike (S-)protein in cytoplasmic membranes of erythrocyte liposomes. A surfactant was used stabilize S-protein’s structure aqueous environment before insertion and facilitate reconstitution S-proteins membranes. The process studied using coarse grained Molecular Dynamics (MD) simulations. Liposome formation S-protein anchoring by...
Understanding the efficacy of SARS-CoV-2 vaccination in people on immunosuppressive drugs, including those with rheumatoid arthritis (RA), is critical for their protection. Vaccine induced protection requires antibodies, CD4+ T cells, and CD8+ but it unclear if these are equally affected by immunomodulatory drugs. Here, we determined how humoral cellular responses differed between RA controls, which drug classes impacted responses. Blood was collected from participants drugs controls after...
While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated impact of common, acute prior to onset on ALS progression in SOD1G93A mouse model. A single sublethal infection clinical signs was markedly accelerated characterized by rapid loss hindlimb function. Prior resulted gliosis lumbar spine and upregulation transcriptional pathways involved...
<title>Abstract</title> Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined impact repeated on phenotypic and functional exhaustion frail older adults long-term care, individuals immunosuppressive drugs, healthy adults. Spike-specific CD4<sup>+</sup> CD8<sup>+</sup> levels did not decline any cohort following vaccination, nor expression...
Abstract Survivors of severe SARS-CoV-2 infections frequently suffer from a range post-infection sequelae. Whether survivors mild or asymptomatic can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype function in individuals who had recovered (n=22) compared those that other respiratory (n=11). Individuals elevated levels C-reactive protein 1-3 months after symptom onset, circulating...
Abstract Lifetime maternal risk of obesity is increased by excess gestational weight gain, which alters metabolic adaptations in pregnancy, but the effects retention/adiposity early postpartum period have not been extensively studied. The pathophysiology adiposity and its accompanying immunometabolic dysregulation are associated with impaired intestinal barrier function both non-pregnant pregnant contexts. Using a mouse model, we investigated diet-induced on physiological during lactation....