A5101528693- Gut microbiota and health
- Polysaccharides and Plant Cell Walls
- Advanced biosensing and bioanalysis techniques
- Botany, Ecology, and Taxonomy Studies
- Plant Physiology and Cultivation Studies
- Food composition and properties
- Postharvest Quality and Shelf Life Management
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Histone Deacetylase Inhibitors Research
- Proteins in Food Systems
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- HIV Research and Treatment
- IL-33, ST2, and ILC Pathways
- Nutritional Studies and Diet
- Microscopic Colitis
- Immune cells in cancer
- Fungal Biology and Applications
- Renal cell carcinoma treatment
- Diabetic Foot Ulcer Assessment and Management
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Wuhan University
2023-2025
Zhongnan Hospital of Wuhan University
2023-2025
Gansu Agricultural University
2024-2025
Shihezi University
2023-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Tianjin University of Science and Technology
2019-2024
Population Health Research Institute
2023-2024
McMaster University
2020-2024
Event-driven bifunctional molecules, typified by proteolysis targeting chimera (PROTAC) technology, have been successfully applied in degrading many proteins of interest (POI). Due to the unique catalytic mechanism, PROTACs will induce multiple cycles degradation until elimination target protein. Here, we propose a versatile "Ligation scavenging" approach terminate event-driven for first time. Ligation scavenging system consists TCO-modified dendrimer (PAMAM-G5-TCO) and tetrazine-modified...
Insoluble dietary fibers (IDFs) demonstrate healthy benefits, while the impact of particle sizes on their properties is far from understood. This study investigated physicochemical and functional IDFs derived wheat bran with three different sizes. Results indicated that water-holding capacity, oil-holding capacity α-amylase activity inhibition IDF had a positive association corresponding size. Meanwhile, grinding progress also influenced antioxidant in which medium size greatest term DPPH,...
Ethnopharmacological relevanceAstragalus polysaccharide (APS), the most biologically active ingredient of Astragali Radix, is used to treat diabetes mellitus (DM)-related chronic wounds in traditional Chinese medicine for several decades. This herb possesses an anti-inflammatory effect. Our study proved that APS can reduce excessive inflammation at late phase wound-healing diabetic ulcers.Aim studyTo clarify molecular mechanism promoting via reducing ulcers during stages...
Within the fields of infectious disease diagnostics, microfluidic-based integrated technology systems have become a vital in enhancing rapidity, accuracy, and portability pathogen detection. These synergize microfluidic techniques with advanced molecular biology methods, including reverse transcription polymerase chain reaction (RT-PCR), loop-mediated isothermal amplification (LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), been successfully used to identify...
SEPN1, a selenoprotein involved in redox regulation and endoplasmic reticulum stress response, has an unclear role cancer. This study aims to investigate the expression, prognostic significance, tumor microenvironment (TME) relevance of SEPN1 across pan-cancer, with particular focus on glioma. We analyzed expression prognosis using TCGA pan-cancer cohort. glioma was further examined data from TCGA, CGGA, GEO, ZN-GC cohorts, along survival analysis, single-cell RNA sequencing enrichment...
MicroRNAs (miRNAs) are short endogenous non-coding RNAs and play important roles in regulating mammary development activities of ovine epithelial cells (OMECs), which affect the milk yield ingredient contents ewes. We previously found that miR-21 was highly expressed tissue, while regulatory mechanisms underlying lactation performance still unclear. Accordingly, this study, we investigated functions OMECs, validated target relationship with a predicted gene programmed cell death 4 (PDCD4) by...
Sarcopenia, characterized by loss of muscle mass and strength, has been linked to various health outcomes, including diabetes mellitus. This study aims investigate the association sarcopenia index, based on serum creatinine cystatin C levels, with incident mellitus in middle-aged older adults China. extracted data from 2015 2020 China Health Retirement Longitudinal Study (CHARLS), age ≥ 45-year without at baseline. Sarcopenia index was calculated assessed through follow-up surveys. Cox...
The influence of phenolic compound extracts from three colored rice cultivars on the gut microbiota was investigated. results revealed that protocatechuic acid, chlorogenic caffeic acid and p-coumaric were major metabolites after fermentation. presence compounds led to a significantly decreased ratio Firmicutes Bacteroidetes, while abundance Proteobacteria decreased. At genus level, promoted an increase Prevotella, Megamonas Bifidobacterium, Bacteroides Escherichia-Shigella inhibited....
Cordycepin (with a molecular formula of C10H13N5O3), natural adenosine isolated from Cordyceps militaris, has an important regulatory effect on skeletal muscle remodelling and quality maintenance. The aim this study was to investigate the cordycepin myoblast differentiation explore underlying mechanisms effect. Our results showed that inhibited myogenesis by downregulating myogenic (MyoD) myogenin (MyoG), preserved undifferentiated reserve cell pools upregulating factor 5 (Myf5)...
Restoring immune tolerance is the ultimate goal for rheumatoid arthritis (RA) treatment. The most reported oral or intravenous injection routes immunization of autoantigens cause gastrointestinal side effects, low patient compliance, and unsatisfied induction. Herein, use a transdermal microneedle patch first time investigated to codeliver CII peptide autoantigen rapamycin reversing disorders RA. immunized microneedles efficiently recruit antigen-presenting cells particularly Langerhans...
This study investigated the effects of different drying methods, including hot-air (HD), freeze (FD), and pressure-differential puffing (PPD), on quality microstructure fresh jujube crisp slices. Our data confirmed that PPD has best effect, followed by FD HD. Crisps dried using had good color rehydration rate, shrinkage volume apparent density. The color, rehydration, hardness fragile chips were similar; slice density increase due to water evaporation during drying. bioavailability was best....
Considering that the study on impact of long-term consumption resistant starch metabolic syndromes induced by a high-fat diet (HFD) is rare, this investigation designed 36-week HFD containing three RS levels (LRS, MRS, and HRS) for measuring changes in serum parameters, liver transcriptome, gut microbiota. Results indicated all significantly reduced food intakes body gain, followed increased leptin PYY, but did not show dose-dependence. Furthermore, MRS triggered greater number enriched...
Abstract Parenteral vaccines typically can prime systemic humoral immune response, but with limited effects on cellular and mucosal immunity. Here, a subcutis‐to‐intestine cascade for navigating nanovaccines to address this limitation is proposed. This five‐step includes lymph nodes targeting, uptaken by dendritic cells (DCs), cross‐presentation of antigens, increasing CCR9 expression DCs, driving CD103 + DCs mesenteric nodes, in short, the LUCID cascade. Specifically, mesoporous silica...
In this study, a label-free multi-resonant graphene-based biosensor with periodic graphene nanoribbons is proposed for detection of composite vibrational fingerprints in the mid-infrared range. The multiple signals biomolecules are simultaneously enhanced and detected by different resonances transmission spectrum. Each dips can be independently tuned altering gating voltage applied on corresponding nanoribbon. Geometric parameters investigated optimized to obtain excellent sensing...