A5089092278- Metamaterials and Metasurfaces Applications
- Plasmonic and Surface Plasmon Research
- Photonic and Optical Devices
- Advanced Antenna and Metasurface Technologies
- CRISPR and Genetic Engineering
- Graphene research and applications
- Pluripotent Stem Cells Research
- Microwave Engineering and Waveguides
- Photonic Crystals and Applications
- Advancements in PLL and VCO Technologies
- Advanced Fiber Optic Sensors
- Radio Frequency Integrated Circuit Design
- Fault Detection and Control Systems
- Advanced Control Systems Optimization
- Process Optimization and Integration
- Virus-based gene therapy research
- Antenna Design and Analysis
- Solid State Laser Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Terahertz technology and applications
- Single-cell and spatial transcriptomics
- Thermal Radiation and Cooling Technologies
- Advanced Neural Network Applications
- Neural Networks and Reservoir Computing
- Analog and Mixed-Signal Circuit Design
Mengchao Hepatobiliary Hospital
2025
Fujian Medical University
2025
Pudong New Area People's Hospital
2025
Xiamen University of Technology
2015-2024
Center for Excellence in Brain Science and Intelligence Technology
2016-2021
Chinese Academy of Sciences
2008-2021
Institute of Microelectronics
2020-2021
Zhejiang University of Technology
2004-2021
New A Innovation (China)
2020-2021
Xiamen University
2009-2019
Enhancement and manipulation of light absorption in graphene is a significant issue for applications graphene-based optoelectronic devices. In order to achieve this purpose the visible region, we demonstrate design optical absorber inspired by metal-dielectric-metal metamaterial perfect electromagnetic waves. The absorbance ratios single three atomic layer are enhanced up 37.5% 64.8%, respectively. shows polarization-dependence tolerates wide range incident angles. Furthermore, peak position...
The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-edited animals showed mosaicism, with editing occurring only in a portion cells. Here we show that single gene or multiple genes can be completely knocked out mouse and monkey embryos by zygotic injection Cas9 mRNA adjacent single-guide RNAs (spaced 10-200 bp apart) target key exon each gene. Phenotypic analysis F0 mice following targeted deletion eight on Y chromosome individually demonstrated robustness...
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys circadian-related disorders by CRISPR/Cas9 editing monkey embryos. These showed higher nocturnal locomotion reduced sleep, which was further exacerbated constant light regimen. Physiological circadian reflected markedly dampened arrhythmic blood hormonal levels....
We numerically demonstrate a tunable broadband terahertz absorber with near-unity absorption by using multilayer graphene ribbons sandwiched in plasmonic integrated structure. By stacking slightly different widths of configuration, the bandwidth can be increased because resonant modes closely positioned together. The spectrum's center frequency manipulated varying graphene's chemical potential, which provides flexible way to design and optimize property after fabrication. Furthermore,...
Two-dimensional materials (2DMs) such as graphene and black phosphorus (BP) have aroused considerable attentions in the past few years. Engineering enhancing their light-matter interaction is possible due to support for localized surface plasmon resonances infrared regime. In this paper, we proposed an broadband absorber consisting of multilayer graphene-BP nanoparticles sandwiched between dielectric layers. Benefiting from properties BP, exhibits both perfect responses strong anisotropy...
The key to leak detection and location in water supply pipelines is signal denoising feature extraction. First, this paper, an improved spline-local mean decomposition (ISLMD) proposed eliminate noise interference. Based on the ISLMD of a signal, cross-correlation function between reference product functions component can be obtained. And then PF containing information extracted reasonably. Compared with local decomposition, has higher accuracy location. Second, image recognition method...
In this paper, we theoretically design a dual-band graphene-based terahertz (THz) absorber combining the magnetic resonance with THz cold mirror without any metallic loss. The absorption spectrum of all-dielectric can be actively manipulated after fabrication due to tunable conductivity graphene. After delicate optimization, two ultra-narrow peaks are achieved respective full width at half maximum (FWHM) 0.0272 and 0.0424 THz. Also, investigate effect geometric parameters on performance....
Cloning of macaque monkeys by somatic cell nucleus transfer (SCNT) allows the generation with uniform genetic backgrounds that are useful for development non-human primate models human diseases. Here, we report feasibility this approach SCNT fibroblasts from a monkey (Macaca fascicularis), in which core circadian transcription factor BMAL1 was knocked out clustered regularly interspaced short palindromic repeat/Cas9 gene editing (see accompanying paper). Out 325 embryos transferred into 65...
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene that inactivate expression of product, fragile mental retardation 1 protein (FMRP). In this study, we used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) technology to generate Fmr1 knockout (KO) rats disruption fourth exon gene. Western blotting analysis confirmed FMRP was absent from brains KO (Fmr1exon4-KO ). Electrophysiological revealed...
There is an increasing need for timely pipeline leak detection and localization methods, could lead to not only the loss of goods but also considerable environmental economic problems. With rapid development hardware software, algorithms have been widely researched applied in many Fields. However, traditional methods are usually limited by extracting features manually, which inefficient time-consuming. Convolutional neuron network effective method extract automatically. In this paper, a...
This paper presents the first fully integrated SONET OC-192 transmitter and receiver fabricated in a standard 0.18-/spl mu/m CMOS process. The consists of an input data register, 16-b-wide first-in-first-out (FIFO) circuit, clock multiplier unit (CMU), 16:1 multiplexer to give 10-Gb/s serial output. integrates amplifier for data, recovery circuit (CDR), 1:16 demultiplexer, drivers low-voltage differential signal (LVDS) outputs. An on-chip LC-type voltage-controlled oscillator (VCO) is...
Modulating spatial near-infrared light for ultra-compact electro-optic devices is a critical issue in optical communication and imaging applications. To date, modulators based on graphene have been reported, but they showed limited modulation effects due to the relatively weak light-graphene interaction. In combination with metallic nanoslits, we design kind of ultrathin perfect absorber enhanced independence wide range incident angles. The modulated spectral shift central wavelength up...
<title>Abstract</title> <bold>Purpose</bold> To comprehensively compare the risk of cardiotoxicity with 5-HT3RAs and to explore underlying pharmacokinetic factors that might partially contribute cardiotoxicity. <bold>Methods</bold> The FDA Adverse Event Reporting System (FAERS) data (January 2004 March 2023) were extracted. Disproportionality analysis by calculating relative odds ratio (ROR) sensitivity analyses conducted assess cardiac signals 5-HT3RAs. Additionally, various parameter...
Background: To explore the magnetic resonance imaging (MRI) features of 2-year follow-up patients with deteriorative mild cognitive impairment (MCI). Methods: A number 105 MCI-afflicted underwent multimodal MRI sequences in 2019 and 2021, respectively. The brain image was segmented into 116 regions, apparent diffusion coefficient (ADC) value, fractional anisotropy (FA) cerebral blood flow (CBF) value each region were extracted by deep learning algorithm. They divided MCI group...
A dual-band absorber using monolayer periodically T-shaped slot-patterned graphene at terahertz frequencies is presented. By changing the dimensions or Fermi levels of graphene, both two absorption bands will be adjusted. The has characteristics polarization independence and incident angle insensitivity. Also, its complementary structure, i.e., strip-patterned investigated to design another absorber. Moreover, triband absorbers are studied through loading four more slots strips in square...
Germ cells are vital for reproduction and heredity. However, the mechanisms underlying female germ cell development in primates, especially late embryonic stages, remain elusive. Here, we performed single-cell RNA sequencing of 12,471 from whole fetal ovaries, explored communications between niche cells. We depicted two waves oogenesis at resolution demonstrated that progenitor theca exhibit similar characteristics to Leydig monkey ovaries. Notably, found ZGLP1 displays differentially...
Enterovirus 71 (EV71) infection is more likely to induce severe complications and mortality than other enteroviruses. Methods for detection of IgM antibody against EV71 had been established years, however, the performance methods in very early diagnosis not fully evaluated, which especially meaningful because short incubation period infection. In this report, an anti-EV71 assay was evaluated using acute sera collected from 165 infected patients, patients with enteroviruses, 2,000 healthy...