Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids,...

Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high...

The key to leak detection and location in water supply pipelines is signal denoising feature extraction. First, this paper, an improved spline-local mean decomposition (ISLMD) proposed eliminate noise interference. Based on the ISLMD of a signal, cross-correlation function between reference product functions component can be obtained. And then PF containing information extracted reasonably. Compared with local decomposition, has higher accuracy location. Second, image recognition method...

The development of injectable hydrogels with good biocompatibility, self-healing, and superior hemostatic properties is highly desirable in emergency clinical applications. Herein, we report an situ self-healing hydrogel based on choline phosphoryl functionalized chitosan (CS-g-CP) oxidized dextran (ODex). CP groups were hypothesized to accelerate hemostasis by facilitating erythrocyte adhesion aggregation. Our results reveal that the CS-g-CP/ODex exhibit enhanced blood clotting...

Developing biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) N-hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked rapidly forms after UV light irradiation covalently bonds to the underlying provide robust adhesion....

Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous...

In this work, we prepared locust bean gum (LBG)/gellan (Gg) double network (DN) hydrogels based on pH-sensitive borate-ester bonds in the LBG and hydrogen-bond-associated double-helix bundles Gg by using two novel natural polysaccharide polymers. The DN with optimized borax concentrations exhibit good mechanical properties (the fracture tensile stress is almost three times that of single hydrogel). Because their unique thermo- structure, LBG/Gg also show excellent self-healing,...

The gastric digestion behavior of differently processed goat milks was investigated using a dynamic in vitro model, the human simulator. Homogenization and heat treatment milk resulted clots with highly fragmented structures. They also delayed pH reduction during digestion, altered chemical composition emptied digesta, promoted release calcium from clots, accelerated hydrolysis emptying proteins. apparent density protein particles location homogenized fat globules changed process, as shown...

Cartilage, as a load-bearing tissue with high-water content, exhibits excellent elasticity and high strength. However, it is still grand challenge to develop cartilage-adaptive biomaterials for replacement or regeneration of damaged cartilage tissue. Herein, protein templating mechanical training integrated fabricate crystal-mediated oriented chitosan nanofibrillar hydrogels (O-CN gels) similar properties water content cartilage. The O-CN gels an ≈74 wt% exhibit tensile strength (≈15.4 MPa)...

The interactions among the proteins in sheep skim milk (SSM) during heat treatments (67.5-90°C for 0.5-30 min) were characterized by kinetics of denaturation whey and association denatured with casein micelles, changes size structure micelles. relationship between micelles is discussed. level β-lactoglobulin (β-LG) α-lactalbumin (α-LA) increased increasing heating temperature time; rates markedly higher β-LG than α-LA range 80 to 90°C; Arrhenius critical was 80°C both α-LA. micelle 7 120 nm,...

Milk is commonly exposed to processing including homogenization and thermal treatment before consumption, this could have an impact on its digestion behavior in the stomach. In study, we investigated vitro gastric of differently processed sheep milks. The samples were raw, pasteurized (75 °C/15 s), homogenized (200/20 bar at 65 °C)–pasteurized, homogenized–heated (95 °C/5 min) was performed using a dynamic system, human simulator with simulated fluid without lipase. pH, structure,...

This study investigated the changes in sheep milk lipids during vitro gastrointestinal digestion response to heat treatment (75°C/15 s and 95°C/5 min) homogenization (200/50 bar) using lipidomics. Homogenized pasteurized had higher levels of polar gastric digesta emptied at 20 min than raw milk. Intense homogenized resulted a reduced level compared with homogenized-pasteurized The release rate free fatty acids small intestinal for followed order: ≤ < homogenized-heated milk; 180 showed...

Currently, the monitoring of health status mechanical systems is becoming more and critical, actual data massive high-dimensional, these are characterized mainly by imbalance. To solve problem low fault recognition rate caused imbalance, this article proposed a novel local non-local information balanced neighborhood graph embedding interpretable deep autoencoder (LGBNGEDAE) method for rotating machinery diagnosis. Specifically, embedded into original objective function to smooth manifold...

Sheep's milk proteins are susceptible to heat-induced coagulation, but the protein interactions under high heat treatment have not been determined. Heat stability and of sheep's skim (SSM) at pH 6.2–7.2 were examined 140 °C. SSM had longest coagulation time 6.9, became very unstable higher or lower pH. Protein aggregates formed consisted mainly whey κ-casein (κ-CN)-depleted casein micelles. Modification alters ionic calcium concentration, dissociation caseins electrostatic interactions,...

The effect of milk fat globule (MFG) size and species (sheep versus cow) on the lipid protein compositions sheep cow milks was studied. MFGs in raw were separated into six significantly different-sized (1.5-5.5 μm) groups by a gravity-based separation method, their fatty acids, lipidomes MFG membranes determined. proportions polar lipids increased but glycoproteins decreased with decreasing both milk; acid composition showed few differences among groups. average each group comparable between...