A5049212731- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Surface Modification and Superhydrophobicity
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Bacteriophages and microbial interactions
- Advanced Biosensing Techniques and Applications
- Bone Tissue Engineering Materials
- Infection Control and Ventilation
- Antimicrobial agents and applications
- Nanofabrication and Lithography Techniques
- Advanced Machining and Optimization Techniques
- Advanced Chemical Sensor Technologies
- Adhesion, Friction, and Surface Interactions
- Advanced Surface Polishing Techniques
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
- Advanced machining processes and optimization
- Dental materials and restorations
- Celiac Disease Research and Management
McMaster University
2017-2025
Harvard University
2015-2016
Boston Children's Hospital
2015
McGill University
2010-2013
Concordia University
2008
Here, we report the development of a transparent, durable, and flexible sensing surface that generates fluorescence signal in presence specific target bacterium. This material can be used packaging, it is capable monitoring microbial contamination various types food products real time without having to remove sample or sensor from package. The was fabricated by covalently attaching picoliter-sized microarrays an E. coli-specific RNA-cleaving fluorogenic DNAzyme probe (RFD-EC1) thin,...
Abstarct Catheter associated thrombosis is an ongoing problem. Omniphobic coatings based on tethering biocompatible liquid lubricants self-assembled monolayers of hydrophobic organosilanes attenuate clotting surfaces. Herein we report efficient, non-invasive and robust process for coating catheters with antithrombotic, omniphobic lubricant-infused produced using chemical vapor deposition (CVD) fluorine-based organosilanes. Compared uncoated catheters, CVD coated significantly attenuated via...
Lubricant-infused omniphobic surfaces have exhibited outstanding effectiveness in inhibiting nonspecific adhesion and attenuating superimposed clot formation compared with other coated surfaces. However, such blindly thwart adhesion, which is troublesome for applications that rely on targeted adhesion. Here we introduce a new class of lubricant-infused offer tunable bioactivity together properties by integrating biofunctional domains into the layer. These novel promote binding desired...
Alzheimer's disease (AD) is one of the main causes dementia worldwide, whereby neuronal death or malfunction leads to cognitive impairment in elderly population. AD highly prevalent, with increased projections over next few decades. Yet current diagnostic methods for occur only after presentation clinical symptoms. Evidence literature points potential mechanisms induction beginning before symptoms start present, such as formation amyloid beta (A
Abstract As bacteriophages continue to gain regulatory approval for personalized human therapy against antibiotic-resistant infections, there is a need transformative technologies rapid target identification through multiple, large, decentralized therapeutic phages biobanks. Here, we design high throughput phage screening platform comprised of portable library individual shelf-stable, ready-to-use phages, in all-inclusive solid tablets. Each tablet encapsulates one along with luciferin and...
Nanofilamentous bacteriophages (bacterial viruses) are biofunctional, self-propagating, and monodisperse natural building blocks for virus-built materials. Minifying phage-built materials to microscale offers the promise of expanding range function these biomaterials sprays colloidal bioassays/biosensors. Here, we crosslink half a million self-organized phages as sole structural component construct each soft microgel. Through an in-house developed, biologics-friendly, high-throughput...
Abstract There is a need for point‐of‐care bacterial sensing and identification technologies that are rapid simple to operate. Technologies do not rely on growth cultures, nucleic acid amplification, step‐wise reagent addition, complex sample processing the key meeting this need. Herein, multiple materials integrated overcoming obstacles in creating one‐pot platforms. Liquid‐infused nanoelectrodes developed reducing nonspecific binding transducer surface; bacterium‐specific RNA‐cleaving...
Abstract An Au‐on‐Au tip sensor is developed for the detection of Salmonella typhimurium ( ), using a new synthetic nucleic acid probe (NAP) as linker immobilization DNA‐conjugated Au nanoparticle (AuNP) onto DNA‐attached thin layer inside pipette tip. In presence , RNase H2 from (STH2) cleaves NAP and freed AuNP can be visually detected by paper strip. This portable biosensor does not require any electronic, electrochemical or optical equipment. It delivers limit 3.2×10 3 CFU mL −1 in 1 h...