A5075641087- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Dermatologic Treatments and Research
- vaccines and immunoinformatics approaches
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Diagnosis and Treatment of Venous Diseases
- Influenza Virus Research Studies
- Systemic Sclerosis and Related Diseases
McMaster University
2023-2024
St. Joseph’s Healthcare Hamilton
2024
Western University
2020-2023
To determine how serologic responses to coronavirus disease 2019 (COVID-19) vaccination and infection in immune-mediated inflammatory (IMID) are affected by time since last other factors.
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like lymphocytes with tremendous antibacterial and immunomodulatory functions. Additionally, MAIT sense respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted immunization strategies against pathogens is unclear. We addressed this question multiple wild-type genetically altered but clinically relevant mouse strains using several vaccine platforms influenza viruses,...
Understanding the efficacy of SARS-CoV-2 vaccination in people on immunosuppressive drugs, including those with rheumatoid arthritis (RA), is critical for their protection. Vaccine induced protection requires antibodies, CD4+ T cells, and CD8+ but it unclear if these are equally affected by immunomodulatory drugs. Here, we determined how humoral cellular responses differed between RA controls, which drug classes impacted responses. Blood was collected from participants drugs controls after...
Abstract Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like lymphocytes with tremendous antibacterial and immunomodulatory functions. MAIT also sense respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted immunization strategies against pathogens is unknown. We addressed this question multiple wild-type genetically altered but clinically relevant mouse strains using several vaccine platforms influenza viruses,...
Infection with (SAg)-producing bacteria may precede or follow infection vaccination against influenza A viruses (IAVs). However, how SAgs alter the breadth of IAV-specific CD8+ T cell (TCD8) responses is unknown. Moreover, whether recall mediating heterosubtypic immunity to IAVs are manipulated by remains unexplored. We employed wild-type (WT) and mutant bacterial SAgs, SAg-sufficient/deficient Staphylococcus aureus strains, WT, mouse-adapted reassortant IAV strains in multiple vivo settings...
<title>Abstract</title> Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined impact repeated on phenotypic and functional exhaustion frail older adults long-term care, individuals immunosuppressive drugs, healthy adults. Spike-specific CD4<sup>+</sup> CD8<sup>+</sup> levels did not decline any cohort following vaccination, nor expression...