Dawn P. Richards
A5036388757- Mental Health and Patient Involvement
- Health Systems, Economic Evaluations, Quality of Life
- Patient-Provider Communication in Healthcare
- Rheumatoid Arthritis Research and Therapies
- Ethics in Clinical Research
- Health Policy Implementation Science
- Clinical practice guidelines implementation
- Healthcare Systems and Technology
- Empathy and Medical Education
- Social Media in Health Education
- Primary Care and Health Outcomes
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Biomedical Ethics and Regulation
- Meta-analysis and systematic reviews
- Adolescent and Pediatric Healthcare
- Statistical Methods in Clinical Trials
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Health Sciences Research and Education
- RNA and protein synthesis mechanisms
- Sports injuries and prevention
- Health and Medical Research Impacts
- Genomics and Chromatin Dynamics
National Patient Safety Foundation
2025
Canadian Arthritis Patient Alliance
2015-2025
Glycemic Index Laboratories
2020-2025
Robarts Clinical Trials
2018-2025
University of British Columbia
2023-2025
Canadian Institutes of Health Research
2022-2025
Ness Technologies
2024
Solutions Inc. (Japan)
2024
Bridge University
2024
CARE Canada
2023
Set2 methylates Lys36 of histone H3. We show here that yeast copurifies with RNA polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated and H3 methylation are associated the coding regions several genes were tested correlate active transcription. Both depend, as well, on Paf1 elongation factor complex. The C terminus Set2, which contains a WW domain, is also required for effective methylation. Deletion CTK1, encoding an RNAPII CTD kinase, prevents recruitment, suggesting...
Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, analytical challenges that potentially compromise the validity of findings. Numerous have required in response COVID-19 pandemic, but guidance for reporting such modifications is incomplete.As a joint extension CONSORT SPIRIT guidelines, CONSERVE (CONSORT Extension RCTs Revised Circumstances) aims improve trial protocols completed undergo important extenuating...
Well designed and properly executed randomised trials are considered the most reliable evidence on benefits of healthcare interventions. However, there is overwhelming that quality reporting not optimal. The CONSORT (Consolidated Standards Reporting Trials) statement was to improve provides a minimum set items be included in report trial. first published 1996, then updated 2001 2010. Here, we present 2025 statement, which aims account for recent methodological advancements feedback from end...
Background Well designed and properly executed randomised trials are considered the most reliable evidence on benefits of healthcare interventions. However, there is overwhelming that quality reporting not optimal. The CONSORT (Consolidated Standards Reporting Trials) statement was to improve provides a minimum set items be included in report trial. first published 1996, then updated 2001 2010. Here, we present 2025 statement, which aims account for recent methodological advancements...
A vector system is described that combines reliable, very low level, regulated protein expression in human cells with two affinity purification tags (Sequential Peptide Affinity, or SPA, system). By avoiding overproduction of the target protein, this allows for efficient natural complexes and their identification by mass spectrometry. We also present an adaptation SPA E. coli and, potentially, other bacteria. Keywords: • protein−protein interactions spectrometry cell
The Strategy for Patient-Oriented Research Chronic Pain Network was founded in 2016 and is a patient-oriented research network funded by the Canadian Institutes of Health Research. incorporates patient partners throughout its governance operations meaning that may contribute to projects ways warrant scientific authorship as defined International Committee Medical Journal Editors. did brief informal review guidance on 2019, but could not find any practical documentation guide members this...
An international panel including patients, clinicians, researchers, acupuncture and surgery trialists, statisticians, experts in clinical epidemiology methodology have developed new guidance for randomised controlled trials acupuncture. It addresses the most prevalent critical concerns of current will help funding agencies, trial registers, journal editors to evaluate relevance, importance, quality submitted proposals completed
Background Since the publication of 2011 European Alliance Associations for Rheumatology (EULAR) recommendations patient research partner (PRP) involvement in rheumatology research, role PRPs has evolved considerably. Therefore, an update was deemed necessary. Methods In accordance with EULAR Standardised Operational Procedures, a task force comprising 13 researchers, 2 health professionals and 10 convened. The process included online meeting, systematic literature review in-person second...
As patient and family engagement activity broadens across the continuum of care expands around world, question compensation for an increasingly competent advisory community continues to come up. The authors are 4 patients who highly active in public involvement initiatives internationally. Through our exclusive perspective, we provide insight into reasoning motivation that many now awakening as why lived experience is a value organizations need recognize support concrete ways. We explore...
Introduction Meaningful patient engagement (PE) can enhance medicines’ development. However, the current PE landscape is fragmentary and lacking comprehensive guidance. Methods We systematically searched for initiatives (SYNaPsE database/publications). Multistakeholder groups integrated these with their own expertise to co-create draft Quality Guidance which was evaluated by public consultation. Projects exemplifying good practice were identified assessed against Criteria create a Book of...
The CONSORT (CONsolidated Standards Of Reporting Trials) 2010 statement is the standard guideline for reporting completed randomised trials. Dose-finding Extension (DEFINE) extends guidance (with 21 new items and 19 modified items) to early phase dose-finding trials with interim dose escalation or de-escalation strategies. Such generally focus on safety, tolerability, activity, recommending dosing scheduling regimens further clinical development. These are often inadequately reported,...
SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 provides guidance clinical trial protocol writing. However, neither the original nor its extensions adequately cover features of early phase dose-finding trials. The Dose-finding Extension (DEFINE) statement is a new guideline that recommendations essential items should be provided in protocols these It details to guidance, incorporating 17 and modifying 15 existing items. purpose this promote transparency,...
Abstract Lipid rafts are membrane microdomains of unique lipid composition that segregate proteins with poorly understood consequences for organization. Identification raft associated could therefore provide novel insight into raft‐dependent functions. Monocytes process antigens presentation to T cells by ingesting pathogens calcium‐dependent plasma invaginations called “phagosomes” which develop sequential fusion the endoplasmic reticulum, early and late endosomes. We investigated protein...