A5067859754- Rheumatoid Arthritis Research and Therapies
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spondyloarthritis Studies and Treatments
- Eosinophilic Esophagitis
- COVID-19 Clinical Research Studies
- Bone health and osteoporosis research
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Voice and Speech Disorders
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Drug-Induced Adverse Reactions
- Patient Satisfaction in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Pain Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Healthcare Policy and Management
- Acute Lymphoblastic Leukemia research
- Asthma and respiratory diseases
- COVID-19 and healthcare impacts
VA Ann Arbor Healthcare System
2019-2025
Michigan Medicine
2017-2025
University of Michigan
2016-2025
VA Center for Clinical Management Research
2018-2025
University of Nebraska Medical Center
2023
VA Salt Lake City Healthcare System
2023
University of Utah
2023
Michigan United
2023
Institute for Healthcare Improvement
2023
Philadelphia VA Medical Center
2023
To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).We analysed the Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD for RA at clinical onset (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 (IL-6i) tumour necrosis factor (TNFi, reference group). The ordinal severity...
Abstract Background Inflammatory bowel disease (IBD) is a chronic characterized by unpredictable episodes of flares and periods remission. Tools that accurately predict course would substantially aid therapeutic decision-making. This study aims to construct model predicts the combined end point outpatient corticosteroid use hospitalizations as surrogate for IBD flare. Methods Predictors evaluated included age, sex, race, corticosteroid-sparing immunosuppressive medications (immunomodulators...
<h3>Importance</h3> Biological therapies have revolutionized inflammatory bowel disease management, but many patients do not respond to biological monotherapy. Identification of likely responders could reduce costs and delays in remission. <h3>Objective</h3> To identify with Crohn be durable ustekinumab before committing long-term treatment. <h3>Design, Setting, Participants</h3> This cohort study analyzed data from 3 phase randomized clinical trials (UNITI-1, UNITI-2, IM-UNITI) conducted...
This cross-sectional study uses direct pharmaceutical claims data from a commercial database to assess the use of 6 types immunosuppressive drugs among commercially insured US adults in 2018 and 2019.
Abstract Objective By magnetic resonance imaging (MRI), subchondral bone attrition (SBA) can be seen in early osteoarthritis (OA), but the significance of this is unknown. We therefore evaluated whether SBA was associated with cartilage loss within same subregion knee. Methods The Multicenter Osteoarthritis Study a cohort individuals who have or are at high risk for knee OA. At baseline and 30 months, participants' MRIs were graded using Whole‐Organ Magnetic Resonance Imaging Score 10...
Oral corticosteroids (OCS) are commonly prescribed for acute, self-limited conditions, despite studies demonstrating toxicity. Studies evaluating longitudinal OCS prescribing in the general population scarce and do not compare use across countries. This study investigated compared prescription patterns from 2009 to 2018 populations of United States, Taiwan, Denmark. international population-based cohort used nationwide claims databases (United States: Optum Clinformatics Data Mart;...
INTRODUCTION: Studies suggest that nonsteroidal anti-inflammatory drugs (NSAID) may contribute to inflammatory bowel disease (IBD) exacerbations. We examined whether variation in the likelihood of IBD exacerbations is attributable NSAID. METHODS: In a cohort patients with (2004–2015), we used 3 analytic methods examine an exacerbation after NSAID exposure. First, matched by propensity for use and association between exposure using adjusted Cox proportional hazards model. To assess residual...
We evaluated changes in long-term glucocorticoid (GC) use and factors associated with persistent GC older adults late-onset rheumatoid arthritis (LORA). Using 20% Medicare data from 2008 to 2017, we identified ≥66 years a new diagnosis of LORA, disease-modifying antirheumatic drug (DMARD) or at least two rheumatologist visits, 12 months follow-up data. Older were categorized as DMARD-exposed DMARD-unexposed based on treatment during the after LORA (index date). For each quarter index date,...
Glucocorticoids are used commonly despite their toxicity and availability of effective alternatives. Prior claims-based studies evaluating effect clinician specialty on glucocorticoid prescribing do not examine how facility-level resources affect patterns. We aim to describe the facility complexity oral in general population. This is a national cross-sectional study Veterans prescribed glucocorticoids during 2021-2022. defined use as ≥1 outpatient pharmacy claim for glucocorticoids,...
Objective. Dyspnoea is a common, multifactorial source of functional impairment among patients with dcSSc. Our objective was to assess the reliability, construct validity and responsiveness change Saint George's Respiratory Questionnaire (SGRQ) in early dcSSc participating multicentre prospective study. Methods. At enrolment 1 year, completed SGRQ (a multi-item instrument four scales: symptoms, activity, impact total), visual analogue scale (VAS) for breathing HAQ Disability Index (HAQ-DI)...
In the Steroid EliMination Rheumatoid Arthritis (SEMIRA) trial, 65% of patients with rheumatoid arthritis (RA) in low disease activity (LDA) on stable biologic therapy successfully tapered glucocorticoids. We aimed to evaluate real-world rates glucocorticoid tapering among similar Veterans Affairs registry.
Objective Glucocorticoids are recommended for short‐term use in rheumatoid arthritis (RA), but many patients continue receiving long‐term therapy. We evaluated the variability glucocorticoid prescribing across rheumatologists to inform interventions limit lowest dose necessary. Methods Two cohorts were created using Medicare data from 2006 2015. Using cohort 1 (RA disease‐modifying antirheumatic drugs [DMARDs]), we calculated each rheumatologist’s “provider preference” glucocorticoids...
Objective. The aim was to evaluate the reliability, validity and responsiveness change of Gout Impact Scale (GIS), a disease-specific measure patient-reported outcomes, in multicentre longitudinal prospective cohort gout patients. Methods. Subjects completed GIS, 24-item instrument with five scales: Concern Overall, Medication Side Effects, Unmet Treatment Need, Well-Being during Attack, Over Attack. total GIS score calculated by averaging scale scores. HAQ-Disability Index (HAQ-DI), Short...