A5100698125- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Infectious Diseases and Tuberculosis
- Glioma Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- MRI in cancer diagnosis
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Biosimilars and Bioanalytical Methods
- Neuroscience and Neuropharmacology Research
- COVID-19 diagnosis using AI
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
Public Health Agency of Canada
2013-2025
University of Michigan
2017-2025
Harvard University
1993-2025
Mass General Brigham
2025
The University of Tokyo
2023-2024
Jikei University School of Medicine
2024
Children's Hospital of Philadelphia
2019-2024
Johns Hopkins University
2013-2024
Johns Hopkins Medicine
2021-2024
Massachusetts General Hospital
2003-2024
Localized translation in mammalian dendrites may play a role synaptic plasticity and contribute to the molecular basis for learning memory. The regulatory mechanisms that control localized neurons are not well understood. We propose microRNAs (miRNAs), class of noncoding RNAs, as mediators neuronal translational regulation. have identified 86 miRNAs expressed neurons, which 40 previously been reported. A subset these exhibits temporally regulated expression cortical cultures. Moreover, all...
ABSTRACT BACKGROUND ChatGPT, a popular new large language model (LLM) built by OpenAI, has shown impressive performance in number of specialized applications. Despite the rising popularity and AI, studies evaluating use LLMs for clinical decision support are lacking. PURPOSE To evaluate ChatGPT’s capacity radiology via identification appropriate imaging services two important presentations: breast cancer screening pain. MATERIALS AND METHODS We compared responses to American College...
Background Large language model (LLM)–based artificial intelligence chatbots direct the power of large training data sets toward successive, related tasks as opposed to single-ask tasks, for which already achieves impressive performance. The capacity LLMs assist in full scope iterative clinical reasoning via successive prompting, effect acting physicians, has not yet been evaluated. Objective This study aimed evaluate ChatGPT’s ongoing decision support its performance on standardized...
Aging results in an elevated burden of senescent cells, senescence-associated secretory phenotype (SASP), and tissue infiltration immune cells contributing to chronic low-grade inflammation a host age-related diseases. Recent evidence suggests that the clearance alleviates its associated dysfunction However, effect this intervention on metabolic function old age remains poorly understood. Here, we demonstrate dasatinib quercetin (D&Q) have senolytic effects, reducing increase...
Large language model (LLM) artificial intelligence (AI) chatbots direct the power of large training datasets towards successive, related tasks, as opposed to single-ask for which AI already achieves impressive performance. The capacity LLMs assist in full scope iterative clinical reasoning via successive prompting, effect acting virtual physicians, has not yet been evaluated.To evaluate ChatGPT's ongoing decision support its performance on standardized vignettes.We inputted all 36 published...
Antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been instrumental in detecting previous exposures and analyzing vaccine-elicited immune responses. Here, we describe a scalable solution to detect quantify SARS-CoV-2 antibodies, discriminate between natural infection- vaccination-induced responses, assess antibody-mediated inhibition of the spike-angiotensin converting enzyme (ACE2) interaction.
The smaller form of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD65) is a major autoantigen in two human diseases that affect its principal sites expression. Thus, destruction pancreatic beta cells, which results insulin-dependent diabetes mellitus (IDDM), and impairment GABA-ergic synaptic transmission Stiff-Man syndrome (SMS) are both characterized by circulating autoantibodies to GAD65. Anti-GAD65 IDDM predominantly directed conformational epitopes. Here we report...
Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question which principal presenters in vivo remains controversial, it has been suggested that this might vary depending on structure a particular antigen. Here we have shown single type cell, CD8α+ DEC-205+ dendritic was mainly responsible for capturing variety different antigens, including multiple forms α-galactosylceramide stimulate...
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are limited therapeutic options for prevention and treatment SARS-CoV-2 infections. We evaluated antiviral activity sulforaphane (SFN), principal biologically active phytochemical derived from glucoraphanin, naturally occurring precursor present in high concentrations cruciferous vegetables. SFN inhibited vitro...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiple immunologic abnormalities and has the potential to involve central nervous system (CNS). The prevalence of SLE seems be growing, possibly because earlier diagnosis improved survival; however, associated mortality still high. with disease-related risk factors such as activity, young age, organ damage or antiphospholipid syndrome (APS). Neuropsychiatric (NPSLE), which caused SLE-related CNS...
Agricultural conversion is one of the most prevalent anthropogenic uses on terrestrial earth. Persistence organisms in such landscapes thought to be related species-specific characteristics as life history traits and dispersal distance. In an agricultural landscape California, we examined local (farm-level) variables associated with nesting preferences native ground-nesting bees. Compared known visitors crops, bee community farms was depauperate. Further, more abundant diverse communities...
We studied a cohort of children initiated on treatment doses combination antiretroviral therapy within 72 hours birth. In who achieved sustained virologic suppression, measures HIV-1 reservoir size in peripheral blood were very low.
Abstract Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard care meshes hernia highly inflammatory and initiates dysregulated process causing visceral adhesions complications. Herein, development an biomaterial scaffold (bioscaffold) presented. The bioscaffold design based on idea that, if excess proinflammatory cytokines are sequestered from site injury by...
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for detection nucleocapsid spike antibodies specific to novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma dried blood spots (DBS).
Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium tuberculosis and approved in combination with bedaquiline linezolid (BPaL) to treat multidrug-resistant (MDR) pulmonary (TB). However, the penetration of these antibiotics into central nervous system (CNS), efficacy BPaL regimen for TB meningitis, are not well established. Importantly, there lack efficacious treatments meningitis due MDR strains, resulting high mortality. We have developed new methods...