A5057446400- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Acute Myeloid Leukemia Research
- Corneal surgery and disorders
- Bone Tissue Engineering Materials
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Chemokine receptors and signaling
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Single-cell and spatial transcriptomics
- Tissue Engineering and Regenerative Medicine
- Advancements in Transdermal Drug Delivery
- Medical and Biological Ozone Research
- Biosimilars and Bioanalytical Methods
- Hernia repair and management
- Hydrogels: synthesis, properties, applications
Columbia University
2023-2025
Columbia University Irving Medical Center
2024-2025
Baylor College of Medicine
2015-2024
Houston Methodist
2017
Ocular Surface Center
2015
Purdue University West Lafayette
2010-2014
Akina (United States)
2009
Presently, eye injuries are treated by topical drop therapy. Because of the ocular surface barriers, drops must be applied several times in a day, causing side effects such as glaucoma, cataract, and poor patient compliance. This article presents development nanowafer drug delivery system which polymer work synergistically to elicit an enhanced therapeutic efficacy with negligible adverse immune responses. The is small transparent circular disc that contains arrays drug-loaded...
The importance and advantages of three-dimensional (3D) cell cultures have been well-recognized. Tumor cells cultured in a 3D culture system as multicellular tumor spheroids (MTS) can bridge the gap between vitro vivo anticancer drug evaluations. An model capable providing close predictions efficacy will enhance our understanding, design, development better delivery systems. Here, we developed an by adapting hydrogel template strategy to uniformly sized scaffold containing microwells. was...
Abstract Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard care meshes hernia highly inflammatory and initiates dysregulated process causing visceral adhesions complications. Herein, development an biomaterial scaffold (bioscaffold) presented. The bioscaffold design based on idea that, if excess proinflammatory cytokines are sequestered from site injury by...
The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of in will guide development treatments improving patient survival.We used syngeneic orthotopic mouse tumour models (wild-type, NOD/scid and Nude), employed knockout (CD8 CD4) administered CXCL4. Tumours lungs were analysed for cancer bioluminescence, circulating isolated from blood. Immunohistochemistry on tumours was performed to confirm cell type, a tissue microarray with 180 TNBCs human relevance....
Purpose: To evaluate the efficacy of a controlled release dexamethasone delivery system for suppressing inflammation in an ocular burn + desiccating stress (OB+DS) model. Methods: Nanowafers (NW) loaded with Dexamethasone (Dex, 10 μg) or vehicles (2.5% Methylcellulose; MC) were fabricated using hydrogel template strategy. C57BL/6 mice subjected to unilateral alkali concomitant 2 5 days and topically treated either μL 0.1% Dex vehicle four times per day compared that had MC-NW Dex-NW placed...
A synergy between the polymer biomaterial and drug plays an important role in enhancing therapeutic efficacy, improving stability, minimizing local immune responses development of delivery systems. Particularly, case ocular delivery, need for synergistic system becomes more pronounced because wet mucosal surface highly innervated cornea, which elicit a strong inflammatory response to instilled formulations. This article presents cysteamine nanowafer treat corneal cystinosis. Corneal...
Diseases affecting the retina, such as age-related macular degeneration (AMD), diabetic retinopathy, edema, and retinal vein occlusions, are currently treated by intravitreal injection of drug formulations. These disease pathologies driven oxidative damage due to chronic high concentrations reactive oxygen species (ROS) in retina. Intravitreal injections often induce detachment, intraocular hemorrhage, endophthalmitis. Furthermore, severe eye pain associated with these lead patient...
High-risk (HR) corneal transplantation presents a formidable challenge, with over 50% of grafts experiencing rejection despite intensive postoperative care involving frequent topical eyedrop administration up to every 2 h, gradually tapering 6-12 months, and ongoing maintenance dosing. While clinical evidence underscores the potential benefits inhibiting angiogenesis, effective antiangiogenesis therapy remains elusive in this context. Here, we engineered controlled-release nanomedicine...
Understanding how intratumoral immune populations coordinate antitumor responses after therapy can guide treatment prioritization. We systematically analyzed an established immunotherapy, donor lymphocyte infusion (DLI), by assessing 348,905 single-cell transcriptomes from 74 longitudinal bone marrow samples of 25 patients with relapsed leukemia; a subset was evaluated both protein- and transcriptome-based spatial analysis. In acute myeloid leukemia (AML) DLI responders, we identified...
Understanding how intra-tumoral immune populations coordinate to generate anti-tumor responses following therapy can guide precise treatment prioritization. We performed systematic dissection of an established adoptive cellular therapy, donor lymphocyte infusion (DLI), by analyzing 348,905 single-cell transcriptomes from 74 longitudinal bone-marrow samples 25 patients with relapsed myeloid leukemia; a subset was evaluated protein-based spatial analysis. In acute myelogenous leukemia (AML)...
Eye injuries due to corneal abrasions, chemical spills, penetrating wounds, and microbial infections cause scarring opacification that result in impaired vision or blindness. However, presently available eye drop formulations of anti-inflammatory antibiotic drugs are not effective their rapid clearance from the ocular surface drug-related side effects such as cataract formation increased intraocular pressure. In this article, we presented development a dextran sulfate-based polymer wafer...
This paper presents an innovative drug delivery using advanced pocket microneedle technology. The integrates two drugs: one housed inside the and other as exterior coating. design allows for targeted of coated to skin's surface pocket-contained inner layers. coating, nitric oxide-polyvinylpyrrolidone (NO-PVP), exhibits antimicrobial properties, while contains niacinamide promote cell proliferation in deeper skin Fabricated diffraction lithography, demonstrates precise control. Successful...
Nitric oxide (NO) is a highly reactive gas molecule, exhibiting antimicrobial properties. Because of its nature, it challenging to store and deliver NO efficiently as therapeutic agent. The objective this study was develop NO-releasing polymeric fibers (NO-fibers), an effective delivery platform for NO. NO-fibers were fabricated with biopolymer solutions polyvinyl pyrrolidone (PVP) ethylcellulose (EC), derivatives N-diazeniumdiolate (NONOate) donor molecules, using electrospinning system. We...
Mutation in nucleophosmin (NPM1) causes relocalization of this normally nucleolar protein to the cytoplasm (