A5003540223- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Acute Ischemic Stroke Management
- Vascular Anomalies and Treatments
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Parasites and Host Interactions
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Atomic and Subatomic Physics Research
- Diabetes Management and Research
Brigham and Women's Hospital
2016-2025
Beth Israel Deaconess Medical Center
2025
Harvard University
2015-2024
Pulmonary and Critical Care Associates
2018-2024
Mass General Brigham
2023
Woman's Hospital
2017
Birmingham VA Medical Center
2015-2016
University of Alabama at Birmingham
2015-2016
Auburn University
2015
University of California, San Diego
2006-2008
Rationale: Deep learning is a powerful tool that may allow for improved outcome prediction.Objectives: To determine if deep learning, specifically convolutional neural network (CNN) analysis, could detect and stage chronic obstructive pulmonary disease (COPD) predict acute respiratory (ARD) events mortality in smokers.Methods: A CNN was trained using computed tomography scans from 7,983 COPDGene participants evaluated 1,000 nonoverlapping 1,672 ECLIPSE participants. Logistic regression (C...
Recent studies show that pulmonary vascular diseases may specifically affect arteries or veins through different physiologic mechanisms. To detect changes in the two trees, physicians manually analyze chest computed tomography (CT) image of patients search abnormalities. This process is time consuming, difficult to standardize, and thus not feasible for large clinical useful real-world decision making. Therefore, automatic separation CT images becoming great interest, as it help accurately...
Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life‐shortening condition. There have been significant in imaging technologies, but evidence of their potential clinical utility, practice variable, dependent part on availability expertise. This statement summarizes current emerging modalities role the diagnosis assessment suspected PH. It also includes review commonly encountered radiological scenarios, modeling‐based biomarkers. An expert panel...
Cor pulmonale (right ventricular [RV] dilation) and cor parvus (RV shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The identification of emphysema as a shared risk factor suggests that additional characterization is needed to understand these widely divergent cardiac processes.
Background Exposure to cigarette smoke has been shown lead vascular remodelling. Computed tomography (CT) imaging measures of pruning have associated with pulmonary disease, an important morbidity smoking. In this study we compare CT-based distal vessel loss histological and parenchymal changes. Methods A retrospective review 80 patients who had undergone lung resection identified appropriate for three-dimensional (3D) reconstruction (n=18) a second group two-dimensional (2D) analysis...
Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is associated with disease severity in patients chronic obstructive disease.Objectives: To determine if pruning asthma and exacerbations.Methods: We measured total blood vessel volume (TBV) vessels less than 5 mm2 cross-sectional area (BV5) 10 (BV10) on noncontrast computed tomographic scans participants from Severe Asthma Research Program. Lower values BV5 to TBV ratio (BV5/TBV) BV10 (BV10/TBV) represented...
Background— Chronic obstructive pulmonary disease causes significant morbidity and concomitant vascular cardiac dysfunction are associated with poor prognosis. Computed tomography–detected relative artery (PA) enlargement defined as a PA to ascending aorta diameter ratio >1 (PA:A>1) is marker for hypertension predicts chronic exacerbations. However, little known about the relationship between PA:A ratio, blood volume, function. Methods Results— A single-center prospective cohort study...
Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have morphologic changes to the vasculature. These include pruning of distal vessels, dilation proximal and increased vascular tortuosity. Advances in image processing computer vision enable objective detection quantification these processes clinically acquired computed tomographic (CT) scans. Three-dimensional reconstructions vasculature were created from CT angiograms 18 patients CTEPH diagnosed using imaging hemodynamics...
Purpose To determine if interstitial features at chest CT enhance the effect of emphysema on clinical disease severity in smokers without pulmonary fibrosis. Materials and Methods In this retrospective cohort study, an objective analysis tool was used to measure (reticular changes, honeycombing, centrilobular nodules, linear scar, nodular subpleural lines, ground-glass opacities) 8266 participants a study chronic obstructive (COPD) called COPDGene (recruited between October 2006 January...
Despite recent advances, the prognosis of pulmonary hypertension (PH) remains poor. While initial insult in PH implicates vasculature, functional state, exercise capacity, and survival such patients are closely linked to right ventricular (RV) function. In current study, we sought investigate effects maximum incremental on matching RV contractility afterload (i.e. ventricular-pulmonary arterial [RV-PA] coupling) with (ePH) (PAH). End-systolic elastance (Ees), (Ea), RV-PA coupling (Ees/Ea)...
Background The relationship between emphysema progression and long-term outcomes is unclear. Purpose To determine the at CT mortality among participants with emphysema. Materials Methods In a secondary analysis of two prospective observational studies, COPDGene (clinicaltrials.gov, NCT00608764) Evaluation Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE; clinicaltrials.gov, NCT00292552), was measured points by using volume-adjusted...
Rationale: The mean pulmonary arterial wedge pressure (mPAWP) is the critical hemodynamic factor differentiating group 1 hypertension (PAH) from 2 associated with left heart disease. Despite discrepancy between mPAWP upper physiologic normal and current PAH definitions, implications of initial for clinical trajectory are poorly understood. Objectives: To model longitudinal trajectories in over 10 years examine factors membership. Methods: Adult patients two or more right catheterizations...
The relationship between longitudinal lung function trajectories, chest computed tomography (CT) imaging, and genetic predisposition to chronic obstructive pulmonary disease (COPD) has not been explored.
Objectives Since pulmonary hypertension (PH) worsens the prognosis of idiopathic fibrosis (IPF), early prediction PH is crucial for timely intervention. This study aims to develop and validate a machine learning model predict using automated CT-based 3D measurements, particularly central cardiovascular structures, segmented by publicly available tool. Methods We retrospectively studied 163 IPF patients who underwent both thin-section chest CT (contrast-enhanced non-contrast) right heart...
Pulmonary hypertension is a heterogeneous disease, and significant portion of patients at risk for it have CT imaging available. Advanced automated processing techniques could be leveraged early detection, screening, development quantitative phenotypes. Pruning vascular tortuosity been previously described in pulmonary arterial (PAH), but the extent these phenomena vs venous vasculature exercise (ePH) not described.What are manifestations pruning using PAH, do they also occur ePH?A cohort...
Background Pulmonary vascular distensibility associates with right ventricular function and clinical outcomes in patients unexplained dyspnea pulmonary hypertension. Alpha coefficient is determined from a nonlinear fit to multipoint pressure-flow plots. Study aims were (1) create test user-friendly tool standardize analysis of exercise hemodynamics including distensibility, (2) investigate changes following treatment arterial Methods Results Participants an heart catherization...