A5005216775- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Heart Failure Treatment and Management
- Tracheal and airway disorders
- Acute Ischemic Stroke Management
- Cardiac Valve Diseases and Treatments
- Hemoglobinopathies and Related Disorders
- Cardiovascular and exercise physiology
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Congenital Diaphragmatic Hernia Studies
- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Congenital Heart Disease Studies
- Thermal Regulation in Medicine
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
Northwestern University
2016-2025
Northwestern Memorial Hospital
2020-2024
Pulmonary and Critical Care Associates
2012-2021
University of Wisconsin–Madison
2016
Northwestern Medicine
2016
National Institutes of Health Clinical Center
2007-2013
National Heart Lung and Blood Institute
2012
National Institutes of Health
2010-2012
Pulmonary Associates
2011
University of Illinois Chicago
2011
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates ventilator-associated (VAP) in clinical trials SARS-CoV-2 are unexpectedly low. Objectives: We conducted an observational single-center study to determine prevalence and etiology at time initial intubation incidence subsequent VAP pneumonia. Methods: Bronchoscopic...
Background Although historical trends before 1998 demonstrated improvements in mortality caused by pulmonary embolism (PE), contemporary estimates of are unknown. Therefore, our objective is to describe death rates PE the United States, overall and sex‐race, regional, age subgroups. Methods Results We used nationwide certificate data from Centers for Disease Control Prevention Wide‐Ranging Online Data Epidemiologic Research calculate age‐adjusted as underlying cause 1999 2018. Joinpoint...
Background: Pulmonary hypertension (PH) in adults with sickle cell disease (SCD) is associated early mortality, but no prior studies have evaluated quantitative relationships of mortality to physiological measures pre- and postcapillary PH.Objectives: To identify risk factors estimate the expected survival a cohort patients SCD PH documented by right heart catheterization.Methods: Nine-year follow-up data (median, 4.7 yr) from National Institutes Health screening study are reported. A total...
Cor pulmonale (right ventricular [RV] dilation) and cor parvus (RV shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The identification of emphysema as a shared risk factor suggests that additional characterization is needed to understand these widely divergent cardiac processes.
Rationale: There are limited data on factors in young adulthood that predict future lung disease.Objectives: To determine the relationship between respiratory symptoms, loss of health, and incident disease a population-based study adults.Methods: We examined prospective from 2,749 participants CARDIA (Coronary Artery Risk Development Young Adults) who completed symptom questionnaires at baseline 2 years later repeated spirometry measurements over 30 years.Measurements Main Results: Cough or...
Ranolazine, a late inward sodium current and fatty acid oxidation inhibitor, may improve right ventricular (RV) function in pulmonary arterial hypertension (PAH); however, the safety efficacy of ranolazine humans with PAH is unknown. Therefore, we sought to (1) determine whether safe well tolerated (2) explore ranolazine's effect on symptoms, exercise capacity, RV structure function, hemodynamic characteristics. We therefore conducted 3-month, prospective, open-label pilot study involving...
Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of could inform prevention strategies for common heart-lung conditions.
Rationale: Beyond the risks of smoking, there are limited data on factors associated with change in lung function over time.Objectives: To determine whether cardiorespiratory fitness was longitudinally preservation health.Methods: Prospective were collected from 3,332 participants Coronary Artery Risk Development Young Adults study aged 18–30 1985 who underwent treadmill exercise testing at baseline visit, and 2,735 a second test 20 years later. The association between covariate adjusted...
Background Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between disease and cardiovascular later life well documented. Whether measured associated with of events unknown. Methods Results CARDIA (The Coronary Artery Risk Development Young Adults) study prospective, multicenter, community‐based, longitudinal cohort including 4761 participants aged 18 to 30 years testing we investigated the health subsequent...
Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms Impact Questionnaire is first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms impacts developed according to 2009 US Food Drug Administration PRO guidance; previous qualitative research patients with PAH supported its initial content validity.Content finalization psychometric validation were...
Abstract Aims The aim is to evaluate associations of lung function impairment with risk incident heart failure (HF). Methods and results Data were pooled across eight US population-based cohorts that enrolled participants from 1987 2004. Participants self-reported baseline cardiovascular disease excluded. Spirometry was used define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) physiology. HF...
There is no consensus on the preferred conduit for right ventricular outflow tract (RVOT) reconstruction congenital cardiac disease. We present a case of 21-year-old woman with history tetralogy Fallot presenting recurrent graft thrombosis and pulmonary emboli in setting RVOT 20-mm expanded polytetrafluoroethylene (ePTFE) valved (GORE PV1, W.L. Gore & Associates). A diagnosis chronic thromboembolic hypertension was made, patient underwent endarterectomy exchange homograft. The novelty...
Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with thromboendarterectomy (PTE) which may lead to reperfusion lung injury (RPLI) and postoperative pneumonia. We aimed describe the incidence, diagnostic characteristics, clinical outcomes of post-PTE pneumonia compared RPLI. A retrospective study involving CTEPH subjects who underwent PTE at a large referral center was conducted. Data included demographics, hemodynamics, microbiologic diagnostics, outcomes. Post-PTE...
Background Pulmonary hypertension (PH) occurs frequently and results in functional limitation advanced COPD. Data regarding the consequence of PH less severe COPD are limited. Whether echocardiographic evidence right sided heart pathology is associated with outcomes patients non-severe unknown. Methods We evaluated pulmonary function, six minute walk distance, echocardiography 74 consecutive performed multivariable linear regression to evaluate association between parameters distance...
Determine the variation in outcomes and respiratory mechanics between subjects who are intubated earlier versus later their coronavirus disease 2019 course.Retrospective cohort study.Northwestern Memorial Hospital ICUs.All patients for March 2020 June 2020.Patients were stratified by time to intubation: 30 4-24 hours after presentation 24 5-10 days presentation. Baseline characteristics, hospitalization, ventilator mechanics, extracted analyzed. Ten clinically available CT scans manually...
<h3>Objective</h3> Inadequate right ventricular (RV) and pulmonary arterial (PA) functional responses to exercise are important yet poorly understood features of hypertension (PAH). This study combined invasive catheterisation with echocardiography assess RV afterload, function ventricular–vascular coupling in subjects PAH. <h3>Methods</h3> Twenty-six PAH were prospectively recruited undergo heart Doppler at rest during incremental exercise, cardiac MRI rest. Measurements included basic...
Ibrutinib, a known Burton's tyrosine kinase (BTK) and interleukin-2 inducible T-cell (ITK) inhibitor, is used for the treatment of B-cell disorders (chronic lymphocytic leukemia [CLL] various other lymphomas) chronic graft versus host disease following allogeneic hematopoietic cell transplantation. Because it considered an immunosuppressant, continuation ibrutinib often debated when patients have active infection, this becomes especially difficult decision in setting coronavirus 2019...
Pulmonary hypertension is a vascular proliferative disease characterized by pulmonary artery remodeling because of dysregulated endothelial and smooth muscle cell proliferation. Although the role inflammation in development not well-defined, plexogenic lesions human are perivascular composed, part, T cells. We explored T-cell infiltration on after damage. induced damage using monocrotaline isolated cells Rag1(tm1Mom) mice performing adoptive transfer. found that causes injury followed...