A5025301161- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Hepatitis C virus research
- Heterotopic Ossification and Related Conditions
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- HIV, Drug Use, Sexual Risk
- Cardiac Valve Diseases and Treatments
- Dermatologic Treatments and Research
- Hepatitis B Virus Studies
- Eosinophilic Disorders and Syndromes
- Esophageal Cancer Research and Treatment
- Uterine Myomas and Treatments
- Healthcare cost, quality, practices
- Catalysis and Hydrodesulfurization Studies
- Catalysts for Methane Reforming
- Heart Failure Treatment and Management
- Mast cells and histamine
- Chemotherapy-induced cardiotoxicity and mitigation
- Sarcoidosis and Beryllium Toxicity Research
- Engineering and Information Technology
Northwestern University
2011-2025
Prisma Health
2024
University of South Carolina
2024
The Hepatitis C Trust
2023
Rush University
2022
Rush University Medical Center
2019-2021
Johns Hopkins Medicine
2018
Johns Hopkins University
1996-2018
Johns Hopkins Hospital
2018
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2018
<h3>Objectives</h3> Recent studies demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma. Investigating risk these biologically relevant subsets may provide an opportunity develop personalised screening guidelines. In this study, we examined distinct serologic phenotypic scleroderma compared estimates with general population. <h3>Methods</h3> Patients Johns Hopkins Scleroderma Center observational...
Objective. Forced vital capacity (FVC) and DLCO are used for screening of systemic sclerosis–associated interstitial lung disease (SSc-ILD). The study purpose was to determine the sensitivity, specificity, negative predictive value (NPV) (proportion true tests) FVC thresholds SSc-ILD on chest high-resolution computed tomography (HRCT) scans. Methods. Patients fulfilling American College Rheumatology 2013 SSc criteria with a HRCT scan pulmonary function tests (PFT) were studied. A thoracic...
Objective This study investigates cancer risk in idiopathic inflammatory myopathy (IIM) relative to the general population. Methods We conducted a single‐center, retrospective cohort of IIM patients and malignancy. Myositis‐specific ‐associated autoantibodies were determined by Euroimmun line blot, enzyme‐linked immunosorbent assay, immunoprecipitation. calculated standardized prevalence ratios (SPRs) adjusted for calendar year, age, sex, race, ethnicity comparing observed cancers versus...
Objective To evaluate the psychometric properties of Scleroderma Skin Questionnaire (SSQ), a novel patient-reported outcome (PRO) to assess systemic sclerosis (SSc) related skin symptoms. Methods The SSQ was administered 799 adults (mean age 52.7; 82% female) enrolled in SSc Collaborative National Quality and Efficacy Registry (CONQUER). Internal consistency determined using Cronbach's α McDonald's ω total (ωt). correlation assessed with modified Rodnan Score (mRSS), Physician Global...
Objective We investigated malignancy risk after renal transplantation in patients with and without systemic lupus erythematosus (SLE). Methods Using the United States Renal Data System from 2001 to 2009, 143 652 transplant recipients SLE contributed 585 420 patient-years of follow-up determine incident cancers using Medicare claims codes. calculated standardised incidence ratios (SIRs) cancer by group age, sex, race/ethnicity-specific calendar year-specific rates compared US population....
Anti-CD18 monoclonal antibodies (MAb) have demonstrated variable protection against neutrophil (PMN)-mediated myocardial reperfusion injury. To identify factors contributing to this variability, open-chest dogs underwent coronary artery occlusion for 90 min followed by 3.5 h. Ten minutes before the received saline (n = 18) or one of three anti-CD18 MAb: MHM.23, R15.7, PLM-2 (2, 1, and 1 mg/kg n 19, 8, 4, respectively). Collateral flow was measured with radioactive microspheres, area at risk...
Background/Objectives: The main aim of this study is to analyze the outcomes NSTEMI admissions and test relevance TIMI as a risk score in real-world setting. We also examine any potential social or health care disparities involved with admissions. This investigates factors associated mortality its correlation heart catheterization during admission. Methods: were analyzed using National Inpatient Sample. scores calculated for their association all-cause was studied. Differences based on...
Objective To determine whether perifollicular hypopigmentation in systemic sclerosis (SSc) is associated with demographics, distinct clinical features, and autoantibody profiles. Methods Patients SSc were prospectively enrolled, a standardized data form used to collect anatomic distribution of hypopigmentation. Associations between features assessed. Results Of 179 adult patients SSc, 36 (20%) had these patients, 94% (n = 34) female 33% 12) limited cutaneous SSc. In univariable logistic...
Objective We tested the hypothesis that higher circulating levels of osteoprotegerin (OPG) are related to coronary artery calcification (CAC) among women with systemic lupus erythematosus (SLE) compared healthy controls (HCs). Methods Among 611 in two age- and race-matched SLE case-control studies, OPG was assayed stored blood samples (HEARTS: plasma, n cases/controls = 122/124, SOLVABLE: serum, 185/180) CAC measured by electron beam computed tomography. Results In both patients had than...
Objective To identify clinical factors, including esophageal dilation on chest high-resolution computed tomography (HRCT), that are associated with pulmonary function decline in patients systemic sclerosis (SSc). Methods Patients fulfilled 2013 SSc criteria and had ≥ 1 HRCT 2 tests (PFTs). According to published methods, widest diameter (WED) radiographic interstitial lung disease (ILD) were assessed, WED was dichotomized as dilated (≥ 19 mm) vs not (< mm). Clinically meaningful PFT...
Abstract Chronic Hepatitis C virus (HCV) infection is a major cause of morbidity and deaths worldwide. HCV treating teams are working toward the goal eliminating by 2030. People who inject drugs (PWIDs) at high risk but contact tracing not routine practice. Here, we present outcomes ‘test, trace treat’ pilot using peer workers to test contacts individuals with HCV. PWIDs were invited participate when they presented for treatment. For those agreeing participate, approached them invite...
High performance, high-temperature hydrogen separation membranes represent a key enabling technology for efficient production using synthesis gas derived from variety of feedstocks. RTI International and Pall Corporation are developing high flux selectivity by depositing thin Pd-alloy films on tubular ceramic/porous stainless steel composite substrates. Both the plating parameters inorganic substrate characteristics being optimized membrane flux. The developmental were used in reactor...
Division of Rheumatology, Department Medicine, Johns Hopkins University, School Baltimore, MD [email protected] Research reported in this publication was supported by the National Institute Arthritis and Musculoskeletal Skin Diseases Institutes Health under award T32AR048522. The content is solely responsibility authors does not necessarily represent official views Health. declare no conflict interest.