A5009298625- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Gynecological conditions and treatments
- Cancer Risks and Factors
- Hernia repair and management
- Cytokine Signaling Pathways and Interactions
- Genomics and Chromatin Dynamics
- Kruppel-like factors research
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Sarcoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
Northwestern University
2016-2025
RELX Group (United States)
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2023
Faculty of 1000 (United States)
2023
Women's Hospital
2015-2021
Northwestern Medicine
2014
Reproductive Science Center
2012
National Institute of Environmental Health Sciences
2012
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012
National Institutes of Health
2012
The conversion of C19 steroids to estrogens occurs in a number tissues, such as the ovary and placenta, is catalyzed by aromatase P450 (P450arom; product CYP19 gene). P450arom expression has also been detected uterine tumors, leiomyomas endometrial cancer. On other hand, was undetectable normal myometrial tissues. present study conducted determine presence or absence peritoneal endometriotic implants eutopic endometrium women with endometriosis. Endometriotic pelvic peritoneum (n = 17; e.g....
C19 steroids are converted to estrogens by aromatase P450 (P450arom). Aromatase expression in humans is regulated use of tissue-specific promoters the placenta (promoter I.1), adipose tissue (promoters I.4, I.3, and II), gonads II). The each promoter gives rise a population P450arom messenger ribonucleic acid (mRNA) species with unique untranslated 5'-terminus. not expressed endometrium disease-free women. We demonstrated, however, presence mRNA pelvic endometriotic implants eutopic...
Uterine leiomyomata (ULs) represent the most common tumor in women and can cause abnormal uterine bleeding, large pelvic masses, recurrent pregnancy loss. Although dependency of UL growth on ovarian steroids is well established, relative contributions 17β-estradiol progesterone are yet to be clarified. Conventionally, estradiol has been considered primary stimulus for growth, studies with cell culture animal models support this concept. In contrast, no research model clearly demonstrated a...
Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles. We found that mRNA protein levels estrogen receptor 2 (ESR2) were strikingly higher, whereas 1 (ESR1), total progesterone (PGR), B (PGR B) significantly lower endometriotic versus endometrial cells. Because ESR2 displayed most striking differential expression between cells, mechanisms for this difference are unknown, we tested hypothesis alteration DNA...
Endometriosis is a gynecological disease defined by the extrauterine growth of endometrial-like cells that cause chronic pain and infertility. The limited to primates exhibit spontaneous decidualization, diseased are characterized significant defects in steroid-dependent genetic pathways typify this process. Altered DNA methylation may underlie these defects, but few regions with differential have been implicated disease. We mapped genome-wide differences between healthy human endometrial...
Estrogen biosynthesis in adipose tissue has assumed great significance terms of a number estrogen-related diseases. Recent evidence suggests that estrogen synthesized locally the breast is singular development cancer elderly women. The from C19 steroids catalyzed by specific form cytochrome P450, namely aromatase P450 (P450arom; product CYP19 gene). human gene comprises nine coding exons, II-X, and its transcripts are expressed ovary, placenta, testes, tissue, brain. Tissue-specific...
ObjectiveTo determine the role of an aromatase inhibitor, letrozole, in treatment reproductive-age women with endometriosis and associated chronic pelvic pain.DesignPhase 2, open-label, nonrandomized proof-of-concept study.SettingOutpatient tertiary-care center.Patient(s)Ten patients endometriosis, all previously treated both medically surgically, unsatisfactory results.Intervention(s)Endometriosis was diagnosed by biopsy scored from initial diagnostic laparoscopy performed within 1 month...