A5026014928- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Glycogen Storage Diseases and Myoclonus
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- stochastic dynamics and bifurcation
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Optical Coherence Tomography Applications
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Advanced MRI Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Advanced Memory and Neural Computing
- Neural and Behavioral Psychology Studies
- Metabolism and Genetic Disorders
- Lymphoma Diagnosis and Treatment
- Child Nutrition and Feeding Issues
Maastricht University
2015-2024
Salford Royal NHS Foundation Trust
2015-2024
Kings Mill Hospital
2021-2024
St Mary's Hospital
2023
The Hepatitis C Trust
2023
Manchester Academic Health Science Centre
2017-2022
Sherwood Forest Hospitals NHS Foundation Trust
2021
University of Salford
1990-2021
Middle East Institute
2018-2020
The Ohio State University
2020
Stochastic resonance can be used as a measuring tool to quantify the ability of human brain interpret noise contaminated visual patterns. Here we report results psychophysics experiment which show that consistently and quantitatively detail in stationary image obscured with time varying both intensity its temporal characteristics strongly determine perceived quality.
Current theories propose that coherence of oscillatory brain activity in the gamma band (30–80 Hz) constitutes an avenue for communication among remote neural populations. However, reports documenting stimulus dependency and time variability frequency suggest distant neuronal populations may, at any one time, operate different frequencies precluding synchronization. To test this idea, we recorded from macaque V1 V2 simultaneously while presenting gratings varying contrast. Although increased...
Ryanodine receptor 1 (RYR1) mutations are a common cause of congenital myopathies associated with both dominant and recessive inheritance. Histopathological findings frequently feature central cores or multi-minicores, more rarely, type predominance/uniformity, fiber-type disproportion, increased internal nucleation, fatty connective tissue. We describe 71 families, 35 RYR1 36 Five the 55 have not been previously reported. Dominant mutations, typically missense, were located in recognized...
Synchronization or phase-locking between oscillating neuronal groups is considered to be important for coordination of information among cortical networks. Spectral coherence a commonly used approach quantify phase locking neural signals. We systematically explored the validity spectral measures quantifying synchronization oscillators. To that aim, we simulated coupled oscillatory signals exhibited dynamics using an abstract phase-oscillator model as well interacting gamma-generating spiking...
Gamma-band activity in visual cortex has been implicated several cognitive operations, like perceptual grouping and attentional selection. So far, it studied primarily under well-controlled fixation conditions using stimuli, isolated bars or patches of grating. If gamma-band is to subserve its purported functions outside the laboratory, should be present during natural viewing conditions. We recorded neuronal with a 252-channel electrocorticographic (ECoG) grid covering large parts left...
Significance When a visual stimulus repeats multiple times, cortical neurons show decreasing firing rate responses, yet neither perception nor stimulus-related behavior is compromised. We that repetition leads to increased neuronal gamma-band (∼40–90 Hz) synchronization within and between early higher areas. The enhanced likely maintains effective signaling in the face of dwindling rates. also gamma rhythm increases for spikes general those putative interneurons, whereas it decreases...
Recent in vitro studies have shown that acetylcholine (ACh) selectively reduces the efficacy of lateral cortical connections via a muscarinic mechanism, while boosting thalamocortical/feed-forward nicotinic mechanism. This suggests high levels ACh should reduce center-surround interactions neurons primary visual cortex, making cells more reliant on feed-forward information. In line with this hypothesis, we show local iontophoretic application primate cortex reduced extent spatial...
Hyperfiltration precedes renal function loss in several nephropathies. Animal studies suggest this may be due to accompanying increases transglomerular capillary hydrostatic pressure difference (delta P) and/or altered glomerular processing of macromolecules. Renal hemodynamics increase strikingly human pregnancy. To test the hypothesis that these alterations are not potentially harmful, clearances inulin, p-aminohippurate, and neutral dextrans were measured at 16- 36-wk gestation, then 4 mo...
Neuronal gamma-band synchronization (25-80 Hz) in visual cortex appears sustained and stable during prolonged stimulation when investigated with conventional averages across trials. However, recent studies macaque have used single-trial analyses to show that both power frequency of gamma oscillations exhibit substantial moment-by-moment variation. This has raised the question whether these apparently random variations might limit functional role for neural processing. Here, we studied...
Fine-scale temporal organization of cortical activity in the gamma range (∼25–80Hz) may play a significant role information processing, for example by neural grouping ('binding') and phase coding. Recent experimental studies have shown that precise frequency oscillations varies with input drive (e.g. visual contrast) it can differ among nearby locations. This has challenged theories assuming widespread synchronization at fixed common frequency. In present study, we investigated which...
Gamma-band synchronization coordinates brief periods of excitability in oscillating neuronal populations to optimize information transmission during sensation and cognition. Commonly, a stable, shared frequency over time is considered condition for functional neural synchronization. Here, we demonstrate the opposite: instantaneous modulations are critical regulate phase relations In monkey visual area V1, nearby local driven by different stimulation showed gamma frequencies. When similar...
Proteins containing PDZ domains are involved in a large number of biological functions, including protein scaffolding, organization ion channels, and signal transduction. We recently identified novel domain-containing protein, PDZK1, that is selectively expressed normal tissues, where it associated colocalized with MAP17, small 17-kDa membrane-associated protein; cMOAT, an organic anion transporter implicated multidrug resistance; the type IIa Na/Pi cotransporter. The cluster formed by cMOAT...
Abstract Cortical processing is strongly influenced by the actions of neuromodulators such as acetylcholine (ACh). Early studies in anaesthetized cats argued that can cause a sharpening orientation tuning functions and an improvement signal‐to‐noise ratio (SNR) neuronal responses primary visual cortex (V1). Recent vitro have demonstrated reduces efficacy feedback intracortical connections via activation muscarinic receptors, increases feed‐forward nicotinic receptors. If mediated or enhanced...
Aging has been associated with declined performance in tasks that rely on working memory (WM). Because attention and WM are tightly coupled, a task older adults could be due to deficits attention, capacity, or both. We used alpha (8-14 Hz) power modulations as an index assess how changes capacity contribute decreased adults. recorded the magnetoencephalogram healthy (60-76 years) younger (18-28 while they performed lateralized task. At matched difficulty, showed significantly lower spans...
A key aspect of higher cortical function is the ability to selectively withhold or suppress action where appropriate. To examine time course executive control we used dense-sensor EEG recording techniques study event-related electrical potentials (ERPs) during a visual 'go/no-go' task. We show that both go and no-go trials there positive deflection in ERP, which develops over posterior parietal sensors ∼350 ms (P300) after onset conditional stimulus, but suppressed trials. also this...
The capacity of human infants to discriminate contrasting speech sounds specializes the native language by end first year life, when signs word recognition have also been found, using behavioural measures. extent voluntary attentional involvement in such has not explored, however, nor do we know what its neural time-course may be. Here demonstrate that 11-month-old children shift their attention automatically familiar words within 250 ms presentation onset measuring event-related potentials...
We developed a novel design of an electrode-pipette combination (EPC) which allows access to brain structures in awake behaving primates without the need for guide tubes or mechanically open dura prior electrode insertion. The EPC consists etched tungsten glass flanked by two pipettes allow local and highly controlled iontophoretic administration neuroactive substances. These EPCs have excellent single cell isolation properties are sturdy enough penetrate primate up 8 weeks following either...
This paper presents a technique for noise and vibration reduction in low-speed sensorless control algorithm of surface mounted permanent magnet synchronous machines (SM-PMSM). The signal processing involved high-frequency-based algorithms has significant effect on the accompanying such algorithms. Therefore, wavelet filtering approach is proposed. filter capable extracting position information even at low values injection voltage amplitude where conventional filters fail to extract...