A5032664136- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- stochastic dynamics and bifurcation
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced Fluorescence Microscopy Techniques
- Memory and Neural Mechanisms
- Integrated Circuits and Semiconductor Failure Analysis
- CCD and CMOS Imaging Sensors
- Nonlinear Dynamics and Pattern Formation
- Advanced Electrical Measurement Techniques
- Neurological disorders and treatments
- Neural Networks and Applications
- Cell Image Analysis Techniques
- Neural and Behavioral Psychology Studies
- Electrical and Bioimpedance Tomography
- Product Development and Customization
- Quantum chaos and dynamical systems
- Advanced Thermodynamics and Statistical Mechanics
- Retinal Development and Disorders
- Force Microscopy Techniques and Applications
- Olfactory and Sensory Function Studies
Boston University
2017-2025
Erasmus University Rotterdam
2024
Erasmus MC
2024
Massachusetts Institute of Technology
2018-2023
McGovern Institute for Brain Research
2018-2023
University of Massachusetts Boston
2022
Maastricht University
2012-2019
Radboud University Nijmegen
2012-2016
Current theories propose that coherence of oscillatory brain activity in the gamma band (30–80 Hz) constitutes an avenue for communication among remote neural populations. However, reports documenting stimulus dependency and time variability frequency suggest distant neuronal populations may, at any one time, operate different frequencies precluding synchronization. To test this idea, we recorded from macaque V1 V2 simultaneously while presenting gratings varying contrast. Although increased...
Synchronization or phase-locking between oscillating neuronal groups is considered to be important for coordination of information among cortical networks. Spectral coherence a commonly used approach quantify phase locking neural signals. We systematically explored the validity spectral measures quantifying synchronization oscillators. To that aim, we simulated coupled oscillatory signals exhibited dynamics using an abstract phase-oscillator model as well interacting gamma-generating spiking...
Abstract Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal information in imaging data), a self-supervised learning method for removing Poisson–Gaussian noise voltage data. is based on the insight that pixel value data highly dependent its neighboring pixels, even when temporally adjacent frames alone do not provide useful statistical prediction. Such dependency captured and used by convolutional neural network with blind spot to accurately denoise which...
Neuronal gamma-band synchronization (25-80 Hz) in visual cortex appears sustained and stable during prolonged stimulation when investigated with conventional averages across trials. However, recent studies macaque have used single-trial analyses to show that both power frequency of gamma oscillations exhibit substantial moment-by-moment variation. This has raised the question whether these apparently random variations might limit functional role for neural processing. Here, we studied...
Fine-scale temporal organization of cortical activity in the gamma range (∼25–80Hz) may play a significant role information processing, for example by neural grouping ('binding') and phase coding. Recent experimental studies have shown that precise frequency oscillations varies with input drive (e.g. visual contrast) it can differ among nearby locations. This has challenged theories assuming widespread synchronization at fixed common frequency. In present study, we investigated which...
Gamma-band synchronization coordinates brief periods of excitability in oscillating neuronal populations to optimize information transmission during sensation and cognition. Commonly, a stable, shared frequency over time is considered condition for functional neural synchronization. Here, we demonstrate the opposite: instantaneous modulations are critical regulate phase relations In monkey visual area V1, nearby local driven by different stimulation showed gamma frequencies. When similar...
Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high-speed membrane voltage fluorescence imaging individual hippocampal CA1 neurons during delivered at 40 Hz or 140 Hz, free electrical interference. powerfully depolarized somatic potentials without suppressing spike rate, especially Hz. Further, paced and timing frequency reduced timed spiking output in response to network...
Abstract Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear how membrane potentials of individual neurons track behavioral rhythms, even though many exhibit pace-making properties in isolated brain circuits. To examine whether single-cell voltage rhythmicity coupled we focused on delta-frequencies (1–4 Hz) that are known occur at both the and levels. We performed imaging striatal simultaneously with network-level local field potential recordings mice...
Intracranial electrical kilohertz stimulation has recently been shown to achieve similar therapeutic benefit as conventional frequencies around 140 Hz. However, it is unknown how influences neural activity in the mammalian brain. Using cellular calcium imaging awake mice, we demonstrate that intracranial at 1 kHz evokes robust responses many individual neurons, comparable those induced by 40 and Hz both hippocampus sensorimotor cortex. The evoked single-cell level are shaped prominent...
Recent improvements in genetically encoded voltage indicators enabled optical imaging of action potentials and subthreshold transmembrane
Hippocampal CA1 neurons generate single spikes and stereotyped bursts of spikes. However, it is unclear how individual dynamically switch between these output modes whether two spiking outputs relay distinct information. We performed extracellular recordings in spatially navigating rats cellular voltage imaging optogenetics awake mice. found that spike are preferentially linked to network theta rhythms (3-12 Hz) encode an animal's position via phase precession, particularly as animals...
Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in coding modulates information transfer between cortical areas. The question arises of how shape within across areas it affects processing. Through local field recordings macaque early cortex while monitoring position network simulations, we...
Voltage imaging with cellular specificity has been made possible by the tremendous advances in genetically encoded voltage indicators (GEVIs). However, kilohertz rates required for lead to weak signals. Moreover, out-of-focus fluorescence and tissue scattering produce background that both undermines signal-to-noise ratio (SNR) induces crosstalk between cells, making reliable
Local field potentials (LFPs) represent the relatively slow varying components of neural signal, and their analysis is instrumental in understanding normal brain function. To be properly analyzed, this signal needs to separated its fundamental frequency bands. Recent studies have shown that empirical mode decomposition (EMD) can exploited pre-process LFP recordings order achieve a proper separation. However, depending on analyzed EMD known generate may cover too wide range considered as...
Gamma oscillations are thought to play a key role in neuronal network function and communication, yet the underlying generating mechanisms have not been fully elucidated date. At least partly, this may be due fact that even simple models of interconnected inhibitory (I) excitatory (E) neurons, many parameters remain unknown set based on practical considerations or by convention. Here, we mitigate problem requiring PING (Pyramidal Interneuron Network Gamma) simultaneously satisfy broad...
The reduced detectability of a target T2 following discrimination preceding T1 in the attentional blink (AB) paradigm is classically interpreted as consequence attention to due allocation T1. Here, we investigated whether AB was related changes microsaccade rate (MSR). We found pronounced MSR signature onset, characterized by suppression from 200 328 ms and enhancement 380 568 ms. Across participants, magnitude correlated with effect such that low corresponded MSR. However, same task, error...
Abstract Cortical synchrony is theorized to contribute communication between connected networks during executive functioning. To understand the functional role of neural in cognitive flexibility, we recorded from auditory cortex (AC) and medial prefrontal (mPFC), while mice performed an extinction learning task. We found that animals gradually showed reduced responding unrewarded tone over hundreds trials, power local field potential (LFP) oscillations (8-18 Hz, centered at alpha/beta...
In our empirical data comprising of single-unit and LFP recordings in macaque area V1 source reconstructed human MEG localized to visual cortex we have observed a robust increase gamma oscillation frequency with increasing luminance contrast. addition, at high grating contrasts, decay power was the [1] but not MEG. These phenomena are key understanding functional role network frequencies for investigating stability oscillations both local macroscopic levels. However, even most basic level...