A5083802365- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- stochastic dynamics and bifurcation
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Advanced MEMS and NEMS Technologies
- Spatial Cognition and Navigation
- Neuroendocrine regulation and behavior
- Advanced Memory and Neural Computing
- Environmental Changes in China
- Visual perception and processing mechanisms
- Multisensory perception and integration
- Acoustic Wave Resonator Technologies
- EEG and Brain-Computer Interfaces
- Remote Sensing and Land Use
- Regional Economic and Spatial Analysis
- Semiconductor Lasers and Optical Devices
Huashan Hospital
2025
Fudan University
2023-2025
Ernst Strüngmann Institute for Neuroscience
2016-2021
Tufts University
2020
Boston University
2017-2020
Max Planck Institute for Brain Research
2020
University Hospital of Zurich
2013
Chinese Academy of Sciences
2011
Kunming Institute of Zoology
2011
Cognition requires the dynamic modulation of effective connectivity, i.e., postsynaptic neuronal response to a given input. If neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized phases high benefit from enhanced connectivity. We show visually induced gamma-band activity in awake macaque area V4 modulates responses unpredictable stimulus events. This exceeded simple additive superposition constant onto ongoing gamma-rhythmic firing,...
Abstract Learned fear and safety are associated with distinct oscillatory states in the basolateral amygdala (BLA) medial prefrontal cortex (mPFC). To determine if how these network support retrieval of competing memories, we mimicked endogenous activity through optogenetic stimulation parvalbumin-expressing interneurons mice during contextual extinction memories. We found that exogenously induced 4 Hz 8 BLA exerts bi-directional control over conditioned freezing behavior an experience-...
Synchronization has been implicated in neuronal communication, but causal evidence remains indirect. We use optogenetics to generate depolarizing currents pyramidal neurons of the cat visual cortex, emulating excitatory synaptic inputs under precise temporal control, while measuring spike output. The cortex transforms constant excitation into strong gamma-band synchronization, revealing well-known cortical resonance. Increasing with ramps increases strength and frequency synchronization....
In Parkinson's disease (PD), reduced dopamine levels in the basal ganglia have been associated with altered neuronal firing and motor dysfunction. It remains unclear whether rate or pattern of neurons leads to parkinsonism-associated present study, we show that increased histaminergic innervation entopeduncular nucleus (EPN) mouse model PD activation EPN parvalbumin (PV) projecting thalamic via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled postsynaptic H2R....
Emotional stimuli have evolutionary significance for the survival of organisms; therefore, they are attention-grabbing and processed preferentially. The neural underpinnings two principle emotional dimensions in affective space, valence (degree pleasantness) arousal (intensity evoked emotion), been shown to be dissociable olfactory, gustatory memory systems. However, separable roles scene perception poorly understood. In this study, we asked how these modulate overt visual attention....
Abstract We investigated the effect of eye‐in‐head and head‐on‐trunk direction on heading discrimination. Participants were passively translated in darkness along linear trajectories horizontal plane deviating 2° or 5° to right left straight‐ahead as defined by subject's trunk. had report whether experienced translation was trunk straight‐ahead. In a first set experiments, head centered fixation lights directed eyes 16° either right. Although eye position not correlated with translation,...
Abstract Activated visual cortex typically engages in neuronal synchronization the gamma-frequency band (30-90 Hz). Gamma-band is related to cognitive functioning, and its mechanisms have been extensively investigated, predominantly through in-vitro studies. To further elucidate in-vivo, we performed simultaneous optogenetic stimulation electrophysiological recordings of cortical areas 17 21a anesthetized cat. Viral transfection with AAV1 or AAV9 under a CamKIIα promoter led robust...
Summary Cognition requires the dynamic modulation of effective connectivity, i.e. postsynaptic neuronal response to a given input. If neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized phases high benefit from enhanced connectivity. We show visually induced gamma-band activity in awake macaque area V4 modulates responses unpredictable stimulus events. This exceeded simple additive superposition constant onto ongoing gamma-rhythmic...
SUMMARY Neuronal activity generates ionic flows and thereby both magnetic fields electric potential differences, i.e. voltages. Voltage measurements are widely used, but suffer from isolating smearing properties of tissue between source sensor, blind to flow direction, reflect the difference two electrodes, complicating interpretation. Magnetic field could overcome these limitations, have been essentially limited magnetoencephalography (MEG), using centimeter-sized, helium-cooled...
Summary The gamma rhythm has been implicated in neuronal communication, but causal evidence remains indirect. We measured spike output of local networks and emulated their synaptic input through optogenetics. Opsins provide currents somato-dendritic membranes, similar to synapses, yet under experimental control with high temporal precision. expressed Channelrhodopsin-2 excitatory neurons cat visual cortex recorded responses light different characteristics. Sine waves frequencies entrained a...
The gamma rhythm has been implicated in neuronal communication, but causal evidence remains indirect. We measured spike output of local networks and emulated their synaptic input through optogenetics. Opsins provide currents somato-dendritic membranes, similar to synapses, yet under experimental control with high temporal precision. expressed Channelrhodopsin‑2 excitatory neurons cat visual cortex recorded responses light different characteristics. Sine waves frequencies entrained a...
Remote sensing dynamic monitoring of land use can detect the change information and update current map, which is important for rational utilization scientific management resources. This paper discusses technological procedure remote including process images, extraction annual use, field survey, indoor post processing accuracy assessment. Especially, we emphasize on comparative research choice rectifying models, image fusion algorithms assessment methods. Taking Anning district in Lanzhou as...
Summary Synchronization has been implicated in neuronal communication, but causal evidence remains indirect. We used optogenetics to generate depolarizing currents pyramidal neurons of cat visual cortex, emulating excitatory synaptic inputs under precise temporal control, while measuring spike output. Cortex transformed constant excitation into strong gamma-band synchronization, revealing the well-known cortical resonance. Increasing with ramps increased strength and frequency...