A5079664491- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- COVID-19 diagnosis using AI
- Neutropenia and Cancer Infections
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Inhalation and Respiratory Drug Delivery
- Nursing Roles and Practices
Northwestern University
2019-2025
La Jolla Alcohol Research
2023
Parks Victoria
2023
Nephrologisches Zentrum Goettingen
2023
RELX Group (United States)
2023
Hamilton Health Sciences
2023
Footscray Hospital
2023
Dialyse Centrum Groningen
2023
Cooperative Trials Group for Neuro-Oncology
2023
Saskatoon Medical Imaging
2023
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates ventilator-associated (VAP) in clinical trials SARS-CoV-2 are unexpectedly low. Objectives: We conducted an observational single-center study to determine prevalence and etiology at time initial intubation incidence subsequent VAP pneumonia. Methods: Bronchoscopic...
BACKGROUNDDespite guidelines promoting the prevention and aggressive treatment of ventilator-associated pneumonia (VAP), importance VAP as a driver outcomes in mechanically ventilated patients, including patients with severe COVID-19, remains unclear. We aimed to determine contribution unsuccessful mortality for pneumonia.METHODSWe performed single-center, prospective cohort study 585 respiratory failure, 190 whom had who underwent at least 1 bronchoalveolar lavage. A panel intensive care...
Abstract Background Clinical end points that constitute successful treatment in severe pneumonia are difficult to ascertain and vulnerable bias. The utility of a protocolized adjudication procedure determine meaningful has not been well described. Methods This was single-center prospective cohort study patients with admitted the medical intensive care unit. objective develop an protocol for bacterial and/or viral pneumonia. Each episode independently reviewed by 2 pulmonary critical...
Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of hospital-acquired pneumonia (HAP) and ventilator-associated (VAP). MRSA associated with significant morbidity mortality. Several virulence factors allow S. to become an effective pathogen. The polysaccharide intracellular adhesin allows for the production biofilms, some strains can produce capsular polysaccharides that protect against phagocytosis, microbial surface components recognizing adhesive matrix molecules...
Critically ill patients who develop invasive pulmonary aspergillosis (IPA) have high mortality rates despite antifungal therapy. Diagnosis is difficult in these and incidences vary the literature. Bronchoalveolar lavage (BAL) fluid galactomannan (GM) a helpful marker, although optimal cutoff unclear. This was single-center cohort study of requiring mechanical ventilation medical intensive care unit (ICU) from June 2018 to March 2023. Demographics, BAL, outcome data were extracted electronic...
In this pilot study, we used shotgun metagenome sequencing (SMS) strategy on bronchoalveolar lavage (BAL) samples from hospitalized patients with suspected ventilate-associated pneumonia (VAP) in order to explore its potential for improving detection of ventilator-associated-pneumonia etiology.In total, 67BAL VAP were tested SMS respiratory pathogens. Results and routine culture compared.SMS detected all pathogens recovered by cultivation approaches. addition, putative other than the...
Abstract Some patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) develop severe pneumonia and the acute respiratory distress syndrome (ARDS) [1]. Distinct clinical features in these have led to speculation that immune response virus SARS-CoV-2-infected alveolus differs from other types of [2]. We collected bronchoalveolar lavage fluid samples 86 SARS-CoV-2-induced failure 252 known or suspected pathogens subjected them flow cytometry bulk transcriptomic...
Abstract Rationale Critically ill patients who develop invasive pulmonary aspergillosis (IPA) have high mortality rates despite antifungal therapy. Diagnosis is difficult in these patients. Bronchoalveolar lavage (BAL) fluid galactomannan (GM) a helpful marker of infection, although the optimal cutoff for IPA unclear. We aimed to evaluate BAL GM and fungal culture results, demographics, outcomes among large cohort mechanically ventilated with suspected pneumonia. Methods A single-center...
Introduction: In patients with suspected pneumonia who are tested respiratory culture and multiplex PCR, the potential added benefit of next-generation sequencing technologies is unknown. Methods: This was a single-center, retrospective study in which residual bronchoalveolar lavage (BAL) specimens were retrieved from hospitalized patients. We compared its research-use-only Respiratory Pathogen Illumina Panel (RPIP) results to BioFire® FilmArray Pneumonia (BioFire® PN) critically ill...
Abstract The microbiology of severe community acquired pneumonia (SCAP) has implications on management, clinical outcomes and public health policy. Therefore, knowledge the etiologies SCAP methods to identify these microorganisms is key. Bacteria including Streptococcus pneumoniae, Staphylococcus aureus Enterobacteriaceae continue be important causes SCAP. Viruses remain most commonly identified etiology Atypical organisms are also critical for health. With increased number immunocompromised...
Severe community-acquired pneumonia secondary to SARS-CoV-2 is a leading cause of death. Current guidelines recommend patients with receive empirical antibiotic therapy for suspected bacterial superinfection, but little evidence supports these recommendations. We obtained bronchoscopic bronchoalveolar lavage (BAL) samples from requiring mechanical ventilation. analyzed BAL multiplex PCR and quantitative culture determine the prevalence superinfecting pathogens at time intubation identify...
Antibiotic stewardship in critically ill pneumonia patients is crucial yet challenging, partly due to the limited diagnostic yield of noninvasive infectious tests. In this study, we report an antibiotic prescription pattern informed by bronchoalveolar lavage (BAL) results, where clinicians de-escalate antibiotics based on combination quantitative cultures and multiplex PCR rapid
Abstract Vancomycin overuse is common, yet few data are available regarding how to improve stewardship of this antibiotic. We identify an association between use a PCR assay rule out MRSA pneumonia and significant, sustained decrease in average vancomycin days therapy over 30-month period.
Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, one the most common reasons for infection-related death worldwide. Causes CAP include numerous viral, bacterial, fungal pathogens, though frequently no specific organism found. Beginning in 2019, COVID-19 pandemic has caused incredible mortality. many features typical such as fever, respiratory distress, cough, can be difficult to distinguish from other types CAP. Here, we highlight unique clinical...
Pneumonia is an infection associated with substantial morbidity and mortality [1]. The etiology of pneumonia often difficult to identify in hospitalized patients, but important ascertain order enhance antibiotic stewardship [2, 3]. There growing interest the use PCR-based diagnostic platforms improve diagnosis treatment intensive care unit (ICU). A test that facilitates prompt identification a pathogen may speed initiation appropriate therapy. Conversely, negative predicts qualitative...