Anthony M. Joudi
A5083791016- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Mechanical Circulatory Support Devices
- Algorithms and Data Compression
- DNA Repair Mechanisms
- Poisoning and overdose treatments
- Vascular Tumors and Angiosarcomas
- Genomics and Phylogenetic Studies
- Sirtuins and Resveratrol in Medicine
- Urinary and Genital Oncology Studies
- Immune responses and vaccinations
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Colorectal Cancer Screening and Detection
- Long-Term Effects of COVID-19
- Autophagy in Disease and Therapy
- Nosocomial Infections in ICU
Northwestern University
2021-2025
Lung Institute
2024
Pulmonary and Critical Care Associates
2021
Loyola University Medical Center
2016
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates ventilator-associated (VAP) in clinical trials SARS-CoV-2 are unexpectedly low. Objectives: We conducted an observational single-center study to determine prevalence and etiology at time initial intubation incidence subsequent VAP pneumonia. Methods: Bronchoscopic...
Regulatory T (Treg) cells orchestrate resolution and repair of acute lung inflammation injury after viral pneumonia. Compared with younger patients, older individuals experience impaired recovery worse clinical outcomes severe infections, including influenza SARS coronavirus 2 (SARS-CoV-2). Whether age is a key determinant Treg cell prorepair function remains unknown. Here, we showed that aging results in cell-autonomous impairment reparative experimental Transcriptional DNA methylation...
FOXP3+ natural regulatory T cells (nTregs) promote resolution of inflammation and repair epithelial damage following viral pneumonia-induced lung injury, thus representing a cellular therapy for patients with acute respiratory distress syndrome (ARDS). Whether in vitro induced Tregs (iTregs), which can be rapidly generated substantial numbers from conventional cells, also recovery is unknown. nTregs require specific DNA methylation patterns maintained by the epigenetic regulator,...
CD4+FOXP3+ regulatory T (Treg) cells maintain self-tolerance, suppress the immune response to cancer, and protect against tissue injury during acute inflammation. Treg require mitochondrial metabolism function, but how adapt their metabolic programs optimize function an occurring in a metabolically stressed microenvironment remains unclear. Here, we tested whether energy homeostasis-maintaining enzyme AMPK aberrant microenvironments caused by malignancy or lung injury, finding that is...
"The Paris System" proposes a 7-tier classification system for urine cytology. Establishing the risk of malignancy (ROM) associated with these diagnostic categories is essential to determine appropriate management patients. The objective this study was ROM "positive" and "suspicious" categories.The authors searched their electronic records cytology specimens that had been diagnosed as or high-grade urothelial carcinoma within an 11-year time frame. Then, determined 6-month follow-up...
Abstract DNA methylation at cytosine-phospho-guanine (CpG) residues is a vital biological process that regulates cell identity and function. Although widely used, bisulfite-based cytosine conversion procedures for sequencing require high temperature extreme pH, which lead to degradation, especially among unmethylated cytosines. Enzymatic (EM-seq), an enzyme-based method, has been proposed as less biased alternative profiling. Compared methods, EM-seq boasts greater genome coverage with GC...
This article has been removed from the AJRCCM website, as it may be revised in near future.
Abstract FOXP3+ regulatory T (Treg) cells are necessary to coordinate resolution of lung inflammation and a return homeostasis after respiratory viral infections, but the specific molecular requirements for these functions cell types governed by Treg remain unclear. This question holds significance as clinical trials transfer therapy infection being planned executed. Here, we report causal experiments in mice determining that control numbers activated CD8+ during recovery from influenza...
Background: Right heart remodeling is noted in patients with severe COVID‐19‐associated acute respiratory distress syndrome (ARDS). There limited information regarding right recovery following lung transplantation this cohort. Methods: Retrospective review of institutional transplant database from June 2020 to 2022 was performed at Northwestern University Chicago, Illinois. Demographic, laboratory, histopathologic, outcomes, and pre‐ postoperative echocardiographic data were recorded...
CD4+FOXP3+ regulatory T (Treg) cells maintain self-tolerance, suppress the immune response to cancer, and protect against tissue injury in lung other organs. Treg require mitochondrial metabolism exert their function, but how adapt metabolic programs sustain optimize function during an occurring a metabolically stressed microenvironment remains unclear. Here, we tested whether energy homeostasis-maintaining enzyme AMP-activated protein kinase (AMPK) aberrant microenvironments caused by...
Abstract Objectives Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Methods Meropenem plasma PK data (n = 70 patients) were modelled, rates calculated for empirical and definitive targets, between-patient variability was quantified [as a coefficient of variation (CV%)]. Results Attainment 100% T>4×MIC variable both (CV% 92) directed 33%) treatment. Conclusions...