A5003492689- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Pericarditis and Cardiac Tamponade
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Trypanosoma species research and implications
- Ultrasound in Clinical Applications
- Acute Myocardial Infarction Research
- Lysosomal Storage Disorders Research
- Cardiac electrophysiology and arrhythmias
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2016-2025
Sequoia (United States)
2024
SEQUOIA (Italy)
2024
Mayo Clinic Hospital
2020-2024
Cleveland Clinic
2024
Mayo Clinic in Florida
2019-2024
WinnMed
2008-2022
University of Minnesota Rochester
2022
University of Rochester
2021
Diastolic dysfunction is a major pathophysiological abnormality in hypertrophic cardiomyopathy (HCM). Doppler echocardiographic parameters correlate with left ventricular (LV) filling pressures other diseases, but it unclear whether these findings apply to patients HCM, who have multiple complex interrelated events leading diastolic dysfunction. This study compares estimates of direct measurements atrial pressure (LAP) via catheterization 100 HCM.One hundred were symptomatic HCM (New York...
Atrial fibrillation (AF) is a common sequela of hypertrophic cardiomyopathy (HCM), but evidence on its prevalence, risk factors, and effect mortality sparse. We sought to evaluate the prevalence AF, identify clinical echocardiographic correlates, assess in large high-risk HCM population.We identified patients who underwent evaluation at our institution from 1975 2012. AF was defined by known history (either chronic or paroxysmal), electrocardiogram, Holter monitoring index visit. examined...
Septal reduction therapy (SRT), surgical myectomy or alcohol ablation, is recommended for obstructive hypertrophic cardiomyopathy (oHCM) patients with intractable symptoms despite maximal medical therapy, but associated morbidity and mortality. This study sought to determine whether the oral myosin inhibitor mavacamten enables improve sufficiently no longer meet guideline criteria choose not undergo SRT. Patients left ventricular (LV) outflow tract (LVOT) gradient ≥50 mm Hg at...
Sex differences in hypertrophic cardiomyopathy (HCM) remain unclear. We sought to characterize sex a large HCM referral centre population.Three thousand six hundred and seventy-three adult patients with underwent evaluation between January 1975 September 2012 1661 (45.2%) female. Kaplan-Meier survival curves were assessed via log-rank test. Cox proportional hazard regression analyses evaluated the relation of survival. At index visit, women older (59 ± 16 vs. 52 15 years, P < 0.0001) had...
Background: Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk sudden cardiac death (SCD) and require a prophylactic implantable cardioverter defibrillator is challenging. In 2014, the European Society Cardiology proposed new stratification method based on prediction model (HCM Risk-SCD) that estimates 5-year SCD. The aim was to externally validate 2014 recommendations in geographically diverse cohort patients recruited from United States, Europe, Middle East,...
Importance Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias individuals hypertrophic cardiomyopathy (HCM) unknown. Objective To determine whether engagement increased for and/or mortality HCM. The a priori hypothesis was that participants engaging activity were not more likely to have arrhythmic event or die than those who reported nonvigorous activity. Design, Setting, and Participants This investigator-initiated, prospective cohort...
Cardiovascular multidisciplinary heart teams (MDHTs) have evolved significantly over the past decade. These play a central role in treatment of wide array cardiovascular diseases affecting interventional cardiology, cardiac surgery, imaging, advanced failure, adult congenital disease, cardio-oncology, and cardio-obstetrics. To meet specific needs both patients programs, composition function MDHTs had to adapt evolve. Although lessons been learned from cancer care, best practices for...
Echocardiographic myocardial dysfunction is reported commonly in sepsis and septic shock, but there are limited data on sepsis-related right ventricular dysfunction. This study sought to evaluate the association of with clinical outcomes patients severe shock. Historical cohort adult admitted all intensive care units at Mayo Clinic from January 1, 2007 through December 31, 2014 for who had an echocardiogram performed within 72 h admission. Patients prior heart failure, cor-pulmonale,...
Background Troponin‐T elevation is seen commonly in sepsis and septic shock patients admitted to the intensive care unit. We sought evaluate role of admission serial troponin‐T testing prognostication these patients. Methods Results This was a retrospective cohort study from 2007 2014 on units at Mayo Clinic with severe shock. Elevated significant delta were defined as ≥0.01 ng/mL ≥0.03 3 hours, respectively. The primary outcome in‐hospital mortality. Secondary outcomes included 1‐year...
Septal reduction therapy (SRT) in patients with intractable symptoms from obstructive hypertrophic cardiomyopathy (oHCM) is associated variable morbidity and mortality. The VALOR-HCM trial (A Study to Evaluate Mavacamten Adults Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Reduction Therapy) examined the effect of mavacamten on need SRT through week 32 oHCM.A double-blind randomized placebo-controlled multicenter at 19 US sites included oHCM maximal tolerated...
Background: In the randomized phase 3 VALOR-HCM study (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) of patients with obstructive hypertrophic cardiomyopathy, mavacamten reduced need septal reduction therapy. Because improves ventricular compliance, this sub-study examined effects treatment cardiac myosin inhibitor on diastolic function. Methods: cardiomyopathy maximally tolerated medical...
The association between new-onset left ventricular (LV) dysfunction during sepsis with long-term heart failure outcomes is lesser understood.Retrospective cohort study of all adult patients severe and septic shock 2007 2014 who underwent echocardiography within 72 h admission to the intensive care unit. Patients prior failure, LV dysfunction, structural disease were excluded. systolic was defined as ejection fraction <50% diastolic ≥grade II. Primary composite outcome included new...
Pulmonary hypertension (PH) is associated with increased mortality in various forms of left-sided heart disease. However, the implications PH hypertrophic cardiomyopathy (HCM) have not been elucidated. The objective this study was to determine prevalence and prognostic HCM. cohort consisted 1570 (54 ± 15 years; 53% male) adults HCM followed for a median 3.3 years. [pulmonary artery systolic pressure (PASP) >36 mmHg] identified 38% patients who were older (57 vs. 52 years, P < 0.0001), more...