A5082357886- Acute Ischemic Stroke Management
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and genetic disorders
- Climate Change and Health Impacts
- Atherosclerosis and Cardiovascular Diseases
- Palliative Care and End-of-Life Issues
- Advanced Neuroimaging Techniques and Applications
- Geriatric Care and Nursing Homes
- Blood Coagulation and Thrombosis Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Family and Patient Care in Intensive Care Units
- Dementia and Cognitive Impairment Research
- DNA and Nucleic Acid Chemistry
- Protease and Inhibitor Mechanisms
- Lipid metabolism and disorders
- Childhood Cancer Survivors' Quality of Life
- Advanced X-ray and CT Imaging
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- MRI in cancer diagnosis
- Neurological Disorders and Treatments
University of Technology Sydney
2017-2025
NHS Highland
2025
Australian Institute of Tropical Health and Medicine
2024
James Cook University
2014-2024
University of Louisville
2010-2022
University of Newcastle Australia
2010-2022
Massachusetts General Hospital
2012-2022
University of Maryland, Baltimore
2012-2022
Harvard University
1986-2022
Hospital de Sant Pau
2022
The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and the best strategy person, given her/his profile?" Without answers to these questions, clinicians struggle make decisions regarding content focus of therapy, researchers design studies that inadvertently mix participants who have a high likelihood responding with those do not. Developing implementing biomarkers distinguish patient subgroups will help address issues unravel...
Abstract Acute ischemic stroke affects men and women differently. In particular, are often reported to experience higher acute severity than men. We derived a low-dimensional representation of anatomical lesions designed Bayesian hierarchical modeling framework tailored estimate possible sex differences in lesion patterns linked (National Institute Health Stroke Scale). This was developed 555 patients (38% female). Findings were validated an independent cohort (n = 503, 41% Here, we show...
Abstract Aim To achieve consensus on the knowledge and skills that undergraduate/pre‐licensure nursing students require to steward healthcare towards a more sustainable future. Design A two‐phase real‐time Delphi study. Methods Phase 1 included generation of Planetary Health, climate change sustainability skill statements based review relevant literature. 2 consisted survey designed seek proposed from panel 42 international experts. Results Of 49 statements, 44 (90%) achieved ≥75% 26 (53%)...
Genome-wide association studies (GWAS) have begun to identify the common genetic component ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power detect associations. As prevalence rates in are markedly affected by age, and younger onset cases may higher predisposition, we investigated whether an age-at-onset approach could novel associations with its...
Elevated plasma homocysteine levels are associated with stroke. However, this might be a reflection of bias or confounding because trials have failed to demonstrate an effect from lowering in stroke patients, although possible benefit has been suggested lacunar Genetic studies could potentially overcome these issues genetic variants inherited randomly and fixed at conception. Therefore, we tested the levels-associated variant MTHFR C677T for association magnetic resonance imaging-confirmed...
Background and Purpose— We evaluated deep learning algorithms’ segmentation of acute ischemic lesions on heterogeneous multi-center clinical diffusion-weighted magnetic resonance imaging (MRI) data sets explored the potential role this tool for phenotyping stroke. Methods— Ischemic stroke from MRI-GENIE (MRI-Genetics Interface Exploration) repository consisting 12 international genetic research centers were retrospectively analyzed using an automated algorithm ensemble 3-dimensional...
To examine whether high white matter hyperintensity (WMH) burden is associated with greater stroke severity and worse functional outcomes in lesion pattern-specific ways.MR neuroimaging NIH Stroke Scale data at index the modified Rankin (mRS) score 3-6 months after were obtained from MRI-Genetics Interface Exploration study of patients acute ischemic (AIS). Individual WMH volume was automatically derived fluid-attenuated inversion recovery images. lesions segmented diffusion-weighted imaging...
The impacts of climate change on planetary health are multifaceted and threaten public gains made since World War II. Healthcare is the fifth largest global emitter greenhouse gas emissions, demanding significant efforts to transition an environmentally sustainable future. Addressing these issues will require collective societal action. In this regard, universities have a dual responsibility - (1) tackle complex social, economic, environmental challenges by championing sustainability...
Genome-wide association studies recently identified 2 variants on chromosome 4q25 as susceptibility factors for atrial fibrillation. Interestingly, these were subsequently also shown to be associated with stroke. However, it remains unclear whether associates all the stroke subtypes or cardioembolic in particular, which is often attributable fibrillation.We performed a large case-control study 4199 ischemic patients, subtyped according Trial of Org 10172 Acute Stroke Treatment criteria, and...
Ideas and Opinions20 October 2015Evolving the Palliative Care Workforce to Provide Responsive, Serious Illness CareArif H. Kamal, MD, MHS, Jennifer M. Maguire, Diane E. Meier, MDArif MHSFrom Duke Cancer Institute, Durham, North Carolina; University of Carolina School Medicine, Chapel Hill, Icahn Medicine at Mount Sinai, New York, York., MDFrom York.Author, Article, Disclosure Informationhttps://doi.org/10.7326/M15-0071 SectionsAboutFull TextPDF ToolsAdd favoritesDownload CitationsTrack...