A5054125964- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Nanoparticles: synthesis and applications
- Hematopoietic Stem Cell Transplantation
- Protease and Inhibitor Mechanisms
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Virus-based gene therapy research
- Hematological disorders and diagnostics
- Advanced biosensing and bioanalysis techniques
- CNS Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Nanocluster Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Antimicrobial Peptides and Activities
Northwestern University
2018-2025
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2018-2024
Duke University
2023
Columbia University
2021
George Washington University
2018
The University of Texas MD Anderson Cancer Center
2018
Rice University
2011-2016
University of California, Irvine
2006-2007
Western Washington University
2004
Gold nanoparticles (AuNPs) are promising vehicles for cancer immunotherapy, with demonstrated efficacy in immune delivery and innate cell stimulation. Nevertheless, their potential has yet to be assessed the vivo application of peptide vaccines. In this study, it is hypothesized that distribution adjuvant qualities AuNPs could leveraged facilitate ovalbumin (OVA) antigen CpG enhance therapeutic effect a B16‐OVA tumor model. AuNP OVA (AuNP‐OVA) (AuNP‐CpG) enhanced both agents induced strong...
Ablative treatments such as photothermal therapy (PTT) are attractive anticancer strategies because they debulk accessible tumor sites while simultaneously priming antitumor immune responses. However, the response following thermal ablation is often insufficient to treat metastatic disease. Here we demonstrate that PTT induces expression of proinflammatory cytokines and chemokines promotes maturation dendritic cells within tumor-draining lymph nodes, thereby T cell Unexpectedly, however,...
Gold nanoparticle accumulation in immune cells has commonly been viewed as a side effect for cancer therapeutic delivery; however, this phenomenon can be utilized developing gold mediated immunotherapy. Here, we conjugated modified CpG oligodeoxynucleotide stimulant to nanoparticles using simple and scalable self-assembled monolayer scheme that enhanced the functionality of vitro vivo. Nanoparticles attenuate systemic effects by enhancing delivery passively innate effector cells. The use...
Nanocarriers have been explored to improve the delivery of tumor antigens dendritic cells (DCs). Gold nanoparticles are attractive nanocarriers because they inert, non-toxic, and can be readily endocytosed by DCs. Here, we designed novel gold-based nanovaccines (AuNVs) using a simple self-assembling bottom-up conjugation method generate high-peptide density effective immune responses with limited toxicity. AuNVs were synthesized optimized DC-to-splenocyte interferon-γ enzyme-linked...
Abstract An in depth analysis of gold nanoparticle (AuNP) synthesis and size tuning, utilizing carbon monoxide (CO) gas as a reducing agent, is presented for the first time. The sizes AuNPs are tunable from ~4 to 100 nm by altering concentration HAuCl 4 inlet CO gas-injection flow rate. It also found that speciation aqueous , prior reduction, influences size, morphology, properties when reduced with gas. Ensemble extinction spectra TEM images provide clear evidence reduction offers high...
Gold nanoparticles (AuNP) have been widely used for drug delivery and recently explored applications in cancer immunotherapy. Although AuNPs are known to accumulate heavily the spleen, particle distribution within immune cells has not thoroughly studied. Here, cellular of Cy5 labeled 50 nm is characterized populations spleen from naïve tumor bearing mice using flow cytometry. Surprisingly, approximately 30% detected taken up by B at 24 h, with about 10% granulocytes, 18% dendritic cells, 8%...
Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet their metabolic requirements. In some malignant cells, de novo synthesis genes are transcriptionally silent mutated, meaning that uptake is required for survival. Recent data suggest lymphoma dependent upon lipoprotein-mediated also subject ferroptosis, an oxygen- and iron-dependent cell death mechanism triggered by accumulation of oxidized lipids in membranes unless the lipid hydroperoxidase,...
Designed and fabrication of a novel magnetic hollow gold nanoshell complexes that incorporates iron oxide nanoparticles in the interior. The combined effect smaller IONPs improved overall properties design MRI contrast capability. complex could be synthesized range 60–80 nm diameter while still having plasmonic peak near infrared region. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may re-organized for...
Abstract Introduction: Ferroptosis is a form of cell death caused by oxidative (-OOH) damage to phospholipids (PL) in the membrane. Understanding mechanisms ferroptosis important because role it plays cancer. Previous work has focused on intracellular antioxidant enzyme glutathione peroxidase 4 (GPx4), which detoxifies PL-peroxides (PL-OOH) and prevents ferroptosis. Studies show that alpha-tocopherol (α-toc), active Vitamin E, an exogenous lipophilic inhibits cancer cells vitro. The α-toc...
Abstract Introduction: PIK-75 is a potent multi-kinase inhibitor, targeting p110α, p38γ and DNA-PKs. We others have demonstrated that effective against diverse range of malignancies, including prostate cancer, cutaneous T-cell lymphomas, acute myeloid leukemia (AML) pancreatic among others. However, hydrophobic difficult to deliver target tissues, which has limited clinical development. To address these limitations, we developed bio-inspired delivery platform for some features natural...
Abstract Introduction: High-grade B-cell lymphomas (HGBCL) with C-MYC and BCL-2 rearrangements are aggressive resistant to standard treatment. Some B cell lymphomas, including HGBCLs diffuse large (DLBCL), susceptible ferroptosis, a death pathway marked by toxic lipid peroxides. We have shown that some DLBCLs sensitive ferroptosis induced gold high-density lipoprotein (HDL)-like nanoparticles (Au-HDL NPs), while others, HGBCLs, more resistant. Differential gene expression (DEG) analysis of...
Abstract Background: Patients with newly diagnosed or relapsed/refractory (R/R) anaplastic thyroid cancer (ATC) and R/R poorly differentiated (PDTC) have limited treatment options an overall poor prognosis. ICAM-1, a cell surface glycoprotein also known as CD54 overexpressed in variety of cancers including cancers, is to play key role tumorigenesis. AIC100 3rd generation ICAM-1 directed CAR T-cell product engineered affinity-tuned technology selectively bind kill tumor cells improve safety....
Abstract The development of immune checkpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed ligand (PD-L1) pathway has significantly transformed landscape cancer treatment. However, resistance mechanisms such as alternative checkpoints, T-cell exhaustion, low tumor burden, and immunosuppressive cells in microenvironment can limit therapeutic efficacy. Recent research highlighted role tumor-derived exosomes expressing PD-L1, which may contribute to by locally systemically...
Ibrutinib, a known Burton's tyrosine kinase (BTK) and interleukin-2 inducible T-cell (ITK) inhibitor, is used for the treatment of B-cell disorders (chronic lymphocytic leukemia [CLL] various other lymphomas) chronic graft versus host disease following allogeneic hematopoietic cell transplantation. Because it considered an immunosuppressant, continuation ibrutinib often debated when patients have active infection, this becomes especially difficult decision in setting coronavirus 2019...
Valve endothelial cells (VEC) have unique phenotypic responses relative to other types of vascular and highly sensitive hemostatic functions affected by changes in valve tissues. Furthermore, effects environmental factors on VEC function has not been characterized. This work used a poly(ethylene glycol) diacrylate (PEGDA) hydrogel platform evaluate the substrate stiffness cell adhesive ligands phenotype expression genes. Hydrogels molecular weights (MWs) 3.4, 8, 20 kDa were polymerized into...