A5080797913- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Pulmonary Hypertension Research and Treatments
- Inflammatory mediators and NSAID effects
- Gynecological conditions and treatments
- Heart Failure Treatment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Prostate Cancer Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Musculoskeletal pain and rehabilitation
- Clostridium difficile and Clostridium perfringens research
- Health Systems, Economic Evaluations, Quality of Life
- Endometrial and Cervical Cancer Treatments
- Helicobacter pylori-related gastroenterology studies
- Pharmacogenetics and Drug Metabolism
- Diagnosis and Treatment of Venous Diseases
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Systemic Sclerosis and Related Diseases
Mayo Clinic in Arizona
2016-2020
Carolina Women's Research and Wellness Center
2020
Actelion (Switzerland)
2010-2019
St. Michael's Hospital
2012
Columbia University
2012
Rutgers, The State University of New Jersey
2007
Merck & Co., Inc., Rahway, NJ, USA (United States)
2003-2007
Johnson & Johnson (United States)
2006
Northwestern University
2004
Battelle
2004
In Brief Study Design. Cross-sectional survey of patients with chronic low back pain in primary care setting. Objectives. To analyze the health resource use, productivity loss, and health-related quality life Sweden. Summary Background Data. Despite clinical economic importance LBP, overall burden disease is not well documented. Methods. data on patients' socio-demographics, disease-related healthcare use during past 6 months, inability to work previous 3 at time study visit were collected...
Idiopathic pulmonary fibrosis is a life-threatening condition, and few data concerning the impact on healthcare utilization associated costs are available. The objective of this study was to describe burden illness (comorbidity, resource utilization, costs) in patients with idiopathic fibrosis.Two cohorts (patients matched controls) were retrospectively identified from US claims databases between January 1, 2001 September 30, 2008. Cases defined by age 55 years or older either two more code...
Regulators and clinical experts increasingly recognize the importance of incorporating patient-reported outcomes (PROs) in studies therapies for pulmonary arterial hypertension (PAH). No PAH-specific instruments have been developed to date accordance with 2009 FDA guidance development PROs as endpoints trials. A qualitative research study was conducted develop a new instrument assessing PAH symptoms their impacts following PRO guidance. cross-sectional at 5 centers US symptomatic patients...
BackgroundPulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives this analysis were evaluate the effect macitentan on HRQoL in patients with PAH Study an Endothelin Receptor Antagonist Pulmonary Arterial Hypertension Improve Clinical Outcome (SERAPHIN) study. association between baseline and long-term outcomes was also investigated.MethodsPatients randomized placebo, 3 mg, or 10 mg once daily. Patients aged 14 years older completed...
Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms Impact Questionnaire is first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms impacts developed according to 2009 US Food Drug Administration PRO guidance; previous qualitative research patients with PAH supported its initial content validity.Content finalization psychometric validation were...
A retrospective, observational, cohort study in primary care. To determine the total direct medical and non-medical cost of chronic low back pain (LBP) France its associated factors. Chronic LBP affects 5-10% population burden is unknown. Ninety-eight randomly selected general practitioners included 796 adult patients with between October 2001 December 2002. Direct costs due to physician visits, investigations, medications, hospitalizations, other resource use were collected for 6 months...
Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, demonstrated testosterone suppression to castrate levels in men with advanced prostate cancer (PCa) the HERO study. Since PCa and its treatments can impact patients' daily life, it is imperative understand of systemic therapy on patient health-related quality life (HRQOL). To report HRQOL for patients relugolix compared those leuprolide on-treatment recovery periods A phase 3 randomized controlled study was conducted 934...
ObjectivesA new patient-reported outcome (PRO) instrument to measure fatigue symptoms and impacts in relapsing multiple sclerosis (RMS) was developed a qualitative stage, followed by psychometric validation migration from paper an electronic format.MethodsAdult patients with relapsing-remitting (RRMS) were interviewed elicit fatigue-related impacts. A draft questionnaire debriefed cognitive interviews further RRMS patients, revised. Content confirmation conducted progressive-relapsing (PRMS)...
OBJECTIVE: To assess the effect of once-daily relugolix combination therapy (relugolix-CT: 40 mg, estradiol 1 and norethindrone acetate 0.5 mg) compared with placebo on moderate-to-severe pain in women uterine leiomyomas heavy menstrual bleeding. METHODS: Two replicate, multinational, double-blind, 24-week, randomized, phase 3 studies (LIBERTY 2) were conducted premenopausal leiomyoma–associated bleeding (80 mL or greater per cycle for two cycles 160 during one cycle). A predefined secondary...
Objective: This interview study sought to capture patients' experiences and perceptions of endometriosis symptoms their impacts on daily life, as described by women in own words. Using open-ended questions a concept-elicitation approach, this assessed the signs different aspects quality including activities, functioning, well-being. Materials Methods: included US with moderate-to-severe endometriosis-associated pain who completed one two Phase 3, randomized, double-blind, placebo-controlled...
Background and Purpose— In this analysis of data from a large clinical trial in aneurysmal subarachnoid hemorrhage, the impact angiographic vasospasm (aVSP) on specific patient outcomes inpatient healthcare resource use was assessed. Methods— This post hoc exploratory end points collected for 409 patients with hemorrhage Clazosentan to Overcome Neurological Ischemia Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) trial. Central reviewers graded severity aVSP as none, mild,...
Symptomatic uterine fibroids are burdensome to live with; they associated with symptom-related distress, affect daily activities, and reduce health-related quality of life. The LIBERTY randomized clinical trials showed that oral relugolix combination therapy (40 mg relugolix, 1 estradiol, 0.5 norethindrone acetate once daily) markedly improved fibroid-associated symptoms conditions, including heavy menstrual bleeding, pain, anemia, was well-tolerated.This study aimed evaluate the effect on...
To evaluate the role of common internal controls in a meta-analysis relative efficacy cyclooxygenase 2-selective inhibitors (coxibs) treatment osteoarthritis (OA).A systematic search Medline and US Food Drug Administration electronic databases was performed to identify randomized, placebo-controlled clinical trials coxibs (etoricoxib, celecoxib, rofecoxib, valdecoxib) patients with hip and/or knee OA. The effect size for active (nonsteroidal antiinflammatory drugs [NSAIDs], naproxen) were...
Objective: Niemann-Pick disease type C (NP-C) is a rare and devastating genetic disorder characterised by range of progressive neurological symptoms, which imposes burden on patients, family members, the healthcare system society overall. The objective this study was to assess direct indirect costs associated with NP-C in UK.Methods: This non-interventional, retrospective, cross-sectional cohort based responses from patients and/or their carers/guardians recruited UK database. Resource use...