A5045463696- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Nitric Oxide and Endothelin Effects
- Extracellular vesicles in disease
- Asthma and respiratory diseases
- Metastasis and carcinoma case studies
- Congenital heart defects research
- Lung Cancer Treatments and Mutations
- Adipose Tissue and Metabolism
- Mechanisms of cancer metastasis
- Animal Nutrition and Physiology
- Cancer-related gene regulation
- Cardiovascular Health and Disease Prevention
- Vascular Anomalies and Treatments
- Medical Imaging and Pathology Studies
- Air Quality and Health Impacts
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2025
Universitat de Barcelona
2016-2025
Instituto de Salud Carlos III
2019-2025
Institut d'Investigacions Biomèdiques de Barcelona
2022-2025
Centro de Investigación Biomédica en Red
2011-2024
Centre for Biomedical Network Research on Rare Diseases
2016-2024
Hospital Clínic de Barcelona
2009-2023
Medical Research Network
2015-2023
Universidad de Valladolid
2011
Intimal enlargement of pulmonary arteries is an early change in chronic obstructive disease (COPD). The cellular and extracellular components that are involved this unknown. present study was designed to characterize the structural changes occurring muscular initial stages. Lung specimens from patients with moderate COPD (n=8; forced expiratory volume one second (FEV 1 ), 66±10% predicted) smokers without airflow obstruction (n=7; FEV , 86±6% pred), were investigated by histochemistry matrix...
Inflammation and oxidative stress contribute to muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). Oxidants contained cigarette smoke (CS) induce adverse effects on tissues through phenomena.To explore inflammation quadriceps of human smokers diaphragm limb muscles guinea pigs chronically exposed CS.Muscle function, protein oxidation nitration, antioxidants, oxidized proteins, inflammation, creatine kinase activity, lung structures were investigated vastus...
To investigate whether endothelial dysfunction of pulmonary arteries (PA) is present in patients with mild chronic obstructive disease (COPD) and to what extent it related the morphological abnormalities PA, we studied 41 who underwent lung resection. Patients were divided into following groups: nonsmokers ( n = 7), smokers normal function 13), COPD 21). Endothelium-dependent relaxation mediated by nitric oxide was evaluated vitro PA rings exposed cumulative concentrations acetylcholine...
Endothelial dysfunction and intimal thickening have been shown in pulmonary arteries (PA) of patients with mild chronic obstructive disease (COPD). To investigate whether an inflammatory process related to tobacco smoking might be involved the development vascular abnormalities COPD, we characterized cell infiltrate endothelium-dependent relaxation PA 39 who underwent lung resection, divided into three groups: “nonsmokers” (n = 7); “smokers,” normal function 12); “COPD” 20)....
Cigarette smoking has been associated with alterations in the structure and endothelial function of pulmonary arteries. Nitric oxide (NO) endothelin-1 are endothelium-derived mediators opposite effects on vascular tone cell growth. To investigate whether cigarette could induce changes synthesis these arteries, we compared expression both NO synthase (eNOS) lungs smokers that nonsmokers. Lung tissue samples 23 nine nonsmokers were studied. Expression eNOS artery endothelium was evaluated by...
Chronic obstructive pulmonary disease (COPD) is associated with structural and functional changes in the circulation that commence at an early stage. To investigate whether vascular endothelial growth factor (VEGF) might be implicated as a mediator COPD-associated changes, we studied surgical specimens obtained from 19 nonsmokers, 21 smokers normal lung function, 28 patients moderate COPD, 10 severe emphysema. The expression of VEGF muscular arteries was evaluated by immunohistochemistry,...
The prevalence of cigarette smoking (CS) is increased among obese subjects, who are susceptible to develop nonalcoholic fatty liver disease (NAFLD). We investigated the hepatic effects CS in control and rats. Control Zucker rats were divided into smokers nonsmokers (n = 12 per group). Smoker exposed 2 cigarettes/day, 5 days/week for 4 weeks. assessed by biochemical analysis, histological examination, immunohistochemistry, gene expression analysis. Phosphorylation AKT extracellular...
Endothelial progenitor cells (EPC) have been shown to repair pulmonary endothelium, although they can also migrate into the arterial intima and differentiate smooth muscle-like (mesenchymal) contributing intimal hyperplasia. The molecular mechanisms by which this process proceeds not fully elucidated. Here, we study whether genes involved in endothelial-to-mesenchymal transition (EnMT) may contribute mesenchymal phenotype acquisition of EPC evaluate transforming growth factor β1 (TGFβ1) is...
Chronic obstructive pulmonary disease (COPD) is a major cause of death worldwide. No therapy stopping progress the available.To investigate role soluble guanylate cyclase (sGC)-cGMP axis in development lung emphysema and hypertension (PH) to test whether sGC-cGMP treatment target for these conditions.Investigations were performed human tissue from patients with COPD, healthy donors, mice, guinea pigs. Mice exposed cigarette smoke (CS) 6 hours per day, 5 days week up months treated BAY...
Background Exposure to cigarette smoke has been shown lead vascular remodelling. Computed tomography (CT) imaging measures of pruning have associated with pulmonary disease, an important morbidity smoking. In this study we compare CT-based distal vessel loss histological and parenchymal changes. Methods A retrospective review 80 patients who had undergone lung resection identified appropriate for three-dimensional (3D) reconstruction (n=18) a second group two-dimensional (2D) analysis...
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Abstract Background Cigarette smoking may contribute to pulmonary hypertension in chronic obstructive disease by altering the structure and function of vessels at early stages. The objectives this study were evaluate effects long-term exposure cigarette smoke on endothelial smooth muscle-cell proliferation arteries guinea pigs. Methods 19 male Hartley pigs exposed 7 cigarettes/day, 5 days/week, for 3 6 months. 17 control sham-exposed same periods. Endothelial was evaluated rings artery aorta...
Journal Article Hematological Values for Four Species of Birds Prey Get access F. J. Polo, Polo Departamento de Bioquimica y Fisiologfa, Facultad Biologfa, Universidad Barcelona, E-08071 Spain Search other works by this author on: Oxford Academic Google Scholar Celdrán, Celdrán V. I. Peinado, Peinado G. Viscor, Viscor Palomeque The Condor, Volume 94, Issue 4, 1 November 1992, Pages 1007–1013, https://doi.org/10.2307/1369300 Published: 01 1992 history Received: 03 February Accepted: 27 May
Cigarette smoke (CS) and chronic hypoxia (CH) can produce pulmonary hypertension. Similarities differences between both exposures their interaction have not been explored. The aim of the present study was to investigate effects CS CH, as single factors or in combination, on circulation guinea pig. 51 pigs were exposed for 12 weeks 32 sham-exposed. 50% animals each group additionally CH final 2 weeks. We measured artery pressure ( P pa ), weight ratio right ventricle (RV) left plus septum....
In chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk. The origin these changes their relationship with alterations in the circulation are unknown.To investigate whether number circulating hematopoietic associated hypertension or endothelial function.62 COPD patients 35 controls (18 non-smokers 17 smokers) without risk factors other than cigarette smoking were studied....
Beta-3 adrenergic receptor (β3AR) agonists have been shown to produce vasodilation and prevention of ventricular remodeling in different conditions. Given that these biological functions are critical pulmonary hypertension (PH), we aimed demonstrate a beneficial effect β3AR PH. An experimental study pigs (n = 34) with chronic PH created by vein banding was designed evaluate the acute hemodynamic long-term on hemodynamics, vascular RV performance Ex vivo human experiments were performed...
Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which frequently observed chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small, noncoding RNAs that regulate mRNA expression levels of many genes, leading to the manifestation identity and specific cellular phenotypes. Here, we evaluate miRNA profiles arteries (PAs) patients with COPD its relationship regulation SMC phenotypic change. from PAs 12...
Diagnosis of pulmonary arterial hypertension (PAH) is difficult due to the lack specific clinical symptoms and biomarkers, especially at early stages. We compared plasma metabolic fingerprints PAH patients (n = 20) with matched healthy volunteers using, for first time, untargeted multiplatform metabolomics approach consisting high-performance liquid gas chromatography coupled mass spectrometry. Multivariate statistical analyses were performed select metabolites that contribute most groups'...
Reference values for some hematologic parameters in 19 species and plasma chemical 11 of Psittacine birds, including cockatoos, parrots, amazons, macaws, conures, lories, were established use veterinary medicine. The following studied: hematocrit, hemoglobin concentration, erythrocyte number, mean corpuscular volume, hemoglobin, dimensions, leukocyte number differential count, glucose, urea, uric acid, cholesterol, triglycerides, creatinine, aspartate aminotransferase, alanine alkaline...