A5102007223- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Hormonal Regulation and Hypertension
- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Advanced X-ray and CT Imaging
- Elasticity and Material Modeling
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Paraoxonase enzyme and polymorphisms
- Congenital Heart Disease Studies
- Cholesterol and Lipid Metabolism
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac pacing and defibrillation studies
- Medical Imaging and Pathology Studies
- Cardiac Arrhythmias and Treatments
Valley Health System
2019-2025
Post Graduate Institute of Medical Education and Research
2024-2025
Ridgewood Public Schools
2024
University of Alabama
2005-2024
Summit Medical Group (United States)
2021-2024
Valley Hospital
2023-2024
All India Institute of Medical Sciences
2024
University of Alabama at Birmingham
2013-2023
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2023
Lebanon Valley College
2023
We have shown previously that patients with resistant hypertension and hyperaldosteronism increased brain natriuretic peptide suggestive of intravascular volume. In the present study, we tested hypothesis contributes to cardiac volume overload. Thirty-seven hypertensive (urinary aldosterone > or = 12 microg/24 hours plasma renin activity < 1.0 ng/mL per hour) 71 normal status were studied. Both groups had similar blood pressure left ventricular mass, whereas right end-diastolic volumes...
Abstract Background and Aims In patients with three-vessel disease and/or left main disease, selecting revascularization strategy based on coronary computed tomography angiography (CCTA) has a high level of virtual agreement treatment decisions invasive (ICA). Methods this study, artery bypass grafting (CABG) procedures were planned CCTA without knowledge ICA. The CABG was recommended by central core laboratory assessing the anatomy functionality circulation. primary feasibility endpoint...
Coronary computed tomography angiography provides non-invasive assessment of coronary stenosis severity and flow impairment. Automated artificial intelligence (AI) analysis may assist in precise quantification characterization atherosclerosis, enabling patient-specific risk determination management strategies. This multicentre international study compared an automated deep learning-based method for segmenting atherosclerosis (CCTA) against the reference standard intravascular ultrasound (IVUS).
Background— Although surgery is indicated in patients with mitral regurgitation (MR) when left ventricular (LV) end-systolic (LVES) dimension >40 mm, LV ejection fraction may decrease after valve surgery. We hypothesize that significant remodeling before not reflected by standard echocardiographic parameters measured at the base of heart. Methods and Results— Ninety-four (age, 54±11 years; 38% female) degenerative isolated MR underwent cine magnetic resonance imaging tissue tagging...
The incremental impact of atherosclerosis imaging-quantitative computed tomography (AI-QCT) on diagnostic certainty and downstream patient management is not yet known. aim this study was to compare the clinical utility routine implementation AI-QCT versus conventional visual coronary CT angiography (CCTA) interpretation. In multi-centre cross-over in 5 expert CCTA sites, 750 consecutive adult patients referred for were prospectively recruited. Blinded analysis, site physicians established...
Previous studies suggest that high-density lipoprotein and apoAI inhibit lipopolysaccharide (LPS)-induced inflammatory responses. The goal of the current study was to test hypothesis mimetic peptide L-4F exerts antiinflammatory effects similar apoAI. Pretreatment human umbilical vein endothelial cells (HUVECs) with LPS induced adhesion THP-1 monocytes. Incubation (1 50 microg/mL) reduced in a concentration-dependent manner. This response associated significant reduction synthesis cytokines,...
Background— Chronic obstructive pulmonary disease causes significant morbidity and concomitant vascular cardiac dysfunction are associated with poor prognosis. Computed tomography–detected relative artery (PA) enlargement defined as a PA to ascending aorta diameter ratio >1 (PA:A>1) is marker for hypertension predicts chronic exacerbations. However, little known about the relationship between PA:A ratio, blood volume, function. Methods Results— A single-center prospective cohort study...
Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and associated risk major adverse events (MACE). Methods: Global multicenter registry (CONFIRM2) including symptomatic patients with suspicion CAD referred for CTA. AI-QCT...
High density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) reduce inflammatory responses to lipopolysaccharide (LPS). We tested the hypothesis that apoA-I mimetic peptide 4F prevents LPS-induced defects in blood pressure vascular reactivity. Systolic (SBP) was measured rats at baseline 6 h after injection of LPS (10 mg/kg) or saline vehicle. Subgroups LPS-treated also received scrambled (Sc-4F). administration reduced SBP by 35% compared with baseline. attenuated reduction (17%...
Acute respiratory distress syndrome (ARDS) due to sepsis has a high mortality rate with limited treatment options. High density lipoprotein (HDL) exerts innate protective effects in systemic inflammation. However, its role ARDS not been well studied. Peptides such as L-4F mimic the secondary structural features and functions of apolipoprotein (apo)A-I, major protein component HDL. We set out measure changes HDL sepsis-mediated patients, study potential prevent rodent model lipopolysaccharide...
A patient with a neuroendocrine tumor and history of coronary artery disease underwent PET 68Ga-DOTATATE tracer for visualization. Analysis the scan showed uptake in left ventricle corresponding to previous myocardial infarct. binds by somatostatin receptors (SSTR) it has been proposed that may be useful detection cardiac inflammatory lesions. We aimed test whether SSTR could upregulated fibrotic scar. analyzed samples from patients end-stage ischemic cardiomyopathy (ICM, n = 8) control...
These studies were designed to determine whether the dual-domain peptide with a class A amphipathic helix linked receptor-binding domain of apolipoprotein (apo) E (Ac-hE-18A-NH2) possesses both antidyslipidemic and antiinflammatory properties.A single bolus (15 mg/kg IV) Ac-hE-18A-NH2 that contains LRKLRKRLLR (141- 150-residue region apo E) covalently A-I mimetic 18A not only reduced plasma cholesterol levels (baseline, 562+/-29.0 mg/dL versus 287.7+/-22.0 at 18 hours, P<0.001) in Watanabe...
Although cardiovascular magnetic resonance (CMR) is frequently performed to measure accurate LV volumes and ejection fractions, volume-time curves (VTC) derived filling rates are not routinely calculated due lack of robust segmentation techniques. VTC peak can be used accurately assess diastolic function, an important clinical parameter. We developed a novel geometry-independent dual-contour propagation technique, making use endocardial contours manually drawn at end systole diastole,...