A5029386074- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Radiation Dose and Imaging
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- Coronary Artery Anomalies
- Medical Imaging Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- Cardiac tumors and thrombi
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Atrial Fibrillation Management and Outcomes
- Kawasaki Disease and Coronary Complications
Cardiovascular Research Foundation
2012-2025
University of California, Los Angeles
1984-2025
Cedars-Sinai Smidt Heart Institute
2011-2024
UCLA Medical Center
2021-2024
All India Institute of Medical Sciences
2024
Cedars-Sinai Medical Center
1981-2023
George Washington University
2022
University of California, Irvine
1978-2021
Cardiovascular Medical Group
2008-2020
Ronald Reagan UCLA Medical Center
2016
Background— Guidelines for the management of patients with suspected coronary artery disease (CAD) rely on age, sex, and angina typicality–based pretest probabilities angiographically significant CAD derived from invasive angiography (guideline probabilities). Reliability guideline has not been investigated in referred to noninvasive testing. Methods Results— We identified 14048 consecutive who underwent computed tomographic angiography. Angina typicality was recorded use accepted criteria....
Atherosclerosis evaluation by coronary computed tomography angiography (CCTA) is promising for artery disease (CAD) risk stratification, but time consuming and requires high expertise. Artificial Intelligence (AI) applied to CCTA comprehensive CAD assessment may overcome these limitations. We hypothesized AI aided analysis allows rapid, accurate of vessel morphology stenosis.This was a multi-site study 232 patients undergoing CCTA. Studies were analyzed FDA-cleared software service that...
Importance Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared stress testing in patients stable chest pain have informed guidelines but raise questions about overtesting and excess catheterization. Objective To test a modified cCTA strategy designed to improve clinical efficiency vs usual (UT). Design, Setting, Participants This was pragmatic randomized trial enrolling participants from December 3, 2018, May 18,...
Objective— We sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and determine impact baseline statin aspirin use on mortality. Approach Results— Coronary computed tomographic angiography permits direct visualization CAD. To date, prognostic implications CAD potential benefit directing therapy based have not been carefully examined. A total 27 125 consecutive patients who underwent (12 enrolling centers 6 countries) were prospectively entered...
We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with without diabetes (DM) who are similar CAD risk factors.We identified 23,643 consecutive known undergoing computed tomography angiography. A total 3,370 DM were propensity matched a 1-to-2 fashion to 6,740 unique non-DM individuals. was defined as none, nonobstructive (1-49% stenosis), or obstructive (≥ 50% stenosis). All-cause mortality assessed by risk-adjusted Cox proportional...
In order to define the temporal and quantitative relationship between plasma concentrations of catecholamines extent location myocardial infarction, conscious dogs underwent left anterior descending or circumflex coronary occlusion with continuous haemodynamic monitoring. Plasma noradrenaline adrenaline were measured by serial isotope derivative method infarction size creatine kinase depletion method. Rapid increases in seen within 1 min occlusion. Within first hour profound elevations (10...
The incremental impact of atherosclerosis imaging-quantitative computed tomography (AI-QCT) on diagnostic certainty and downstream patient management is not yet known. aim this study was to compare the clinical utility routine implementation AI-QCT versus conventional visual coronary CT angiography (CCTA) interpretation. In multi-centre cross-over in 5 expert CCTA sites, 750 consecutive adult patients referred for were prospectively recruited. Blinded analysis, site physicians established...
Sequential testing by coronary CT angiography (CTA) and myocardial perfusion SPECT (MPS) obtained on stand-alone scanners may be needed to diagnose artery disease in equivocal cases. We have developed an automated technique for MPS–CTA registration demonstrate its utility improved MPS quantification guiding the coregistered physiologic with anatomic CTA information. <b>Methods:</b> Automated of left ventricular (LV) surfaces trees was accomplished iterative minimization voxel differences...
To date, the therapeutic benefit of revascularization vs. medical therapy for stable individuals undergoing invasive coronary angiography (ICA) based upon computed tomographic (CCTA) findings has not been examined. We examined 15 223 patients without known artery disease (CAD) CCTA from eight sites and six countries who were followed median 2.1 years (interquartile range 1.4–3.3 years) an endpoint all-cause mortality. Obstructive CAD by was defined as a ≥50% luminal diameter stenosis in...
A double‐blind, randomized study was performed to compare the efficacy of intravenous verapamil with saline in 28 patients a rapid ventricular rate and atrial fibrillation or flutter. Conversion sinus rhythm occurred none 14 after 3 20 (15%) 7 160 min verapamil. The slowed ≥15% 2 (14%) by saline, 17 (85%) 1 dose (p < 0.001), 19 (95%) doses 0.001). flutter 4 105 &15% (57%) verapamil, (100%)