A5070050361- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Trauma and Emergency Care Studies
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac Health and Mental Health
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Erythropoietin and Anemia Treatment
- Sepsis Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
University of British Columbia
2016-2025
Vancouver General Hospital
2018-2025
Clinical Research Institute
2015-2024
University of Toronto
1946-2024
Centre for Health Evaluation and Outcome Sciences
2021-2024
Université de Montréal
2024
University of Alberta
2017-2024
The Alfred Hospital
2024
Montreal Heart Institute
2024
Sunnybrook Health Science Centre
2024
Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use diagnostic testing, although there limited data from randomized trials to guide care.
Advanced generation ablation technologies have been developed to achieve more effective pulmonary vein isolation (PVI) and minimize arrhythmia recurrence after atrial fibrillation (AF) ablation.We randomly assigned 346 patients with drug-refractory paroxysmal AF contact force-guided radiofrequency (CF-RF; n=115), 4-minute cryoballoon (Cryo-4; or 2-minute (Cryo-2; n=116). Follow-up was 12 months. The primary outcome time first documented of symptomatic asymptomatic tachyarrhythmia (AF,...
Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic functional testing.
A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from higher level.
Importance Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared stress testing in patients stable chest pain have informed guidelines but raise questions about overtesting and excess catheterization. Objective To test a modified cCTA strategy designed to improve clinical efficiency vs usual (UT). Design, Setting, Participants This was pragmatic randomized trial enrolling participants from December 3, 2018, May 18,...
Many CNS disorders involve an inflammatory response that is orchestrated by cells of the innate immune system: macrophages, neutrophils, and microglia (the endogenous cell). Hence, there considerable interest in anti-inflammatory strategies target these cells. Microglia express Kv1.3 (KCNA3) channels, which we showed previously are important for their proliferation NADPH-mediated respiratory burst. Here, demonstrate potential targeting channels to control inflammation. Rat Kv1.2, Kv1.3,...
Background: Despite rapid clinical adoption of novel anticoagulants, it is unknown whether outcomes differ among patients with worsening renal function (WRF) taking these new drugs compared warfarin. We aimed to determine the primary efficacy (stroke or systemic embolism) and safety (major bleeding nonmajor clinically relevant bleeding) end points from ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention Stroke Embolism...
To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing. We included enrolled the Prospective Multicenter Imaging Study Evaluation Chest Pain (PROMISE) trial randomized CTA. Exclusively level III-certified readers, blinded demographic data, assessed prevalence CAD 50%...
Background: Regional variations in reperfusion times and mortality patients with ST-segment–elevation myocardial infarction are influenced by differences coordinating care between emergency medical services (EMS) hospitals. Building on the Accelerator-1 Project, we hypothesized that time to could be further reduced enhanced regional efforts. Methods: Between April 2015 March 2017, worked 12 metropolitan regions across United States 132 percutaneous coronary intervention–capable hospitals 946...
Little is known about the influence of comprehensive public health initiatives according to out-of-hospital cardiac arrest (OHCA) location, particularly at home, where resuscitation efforts and outcomes have historically been poor.
Up to 50% of patients fail meet ST-segment-elevation myocardial infarction (STEMI) guideline goals recommending a first medical contact-to-device time <90 minutes for directly presenting percutaneous coronary intervention-capable hospitals and <120 transferred patients. We sought increase the proportion treated within by organizing coordinated regional reperfusion plans.
Guidelines recommend noninvasive testing for patients with stable chest pain, although many subsequently have normal test results and no adverse clinical events.To describe a risk tool developed to use only pretest data identify pain coronary arteries events during follow-up (minimal-risk cohort).This secondary analysis of randomized, pragmatic comparative effectiveness trial (Prospective Multicenter Imaging Study Evaluation Chest Pain [PROMISE]) includes stable, symptomatic outpatients...
This study sought to compare the performance of major guidelines for assessment stable chest pain including risk-based (American College Cardiology/American Heart Association and European Society Cardiology) symptom-focused (National Institute Health Care Excellence) strategies.Although noninvasive testing is not recommended in low-risk individuals with pain, recommend differing approaches defining patients.Patient-level data were obtained from PROMISE (Prospective Multicenter Imaging Study...