A5021057705- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Aortic Thrombus and Embolism
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Coronary Artery Anomalies
- Mindfulness and Compassion Interventions
- Resilience and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Radiation Dose and Imaging
- Inflammatory Myopathies and Dermatomyositis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Hormonal and reproductive studies
- Cardiovascular Health and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
University of California, Los Angeles
2017-2025
Harbor–UCLA Medical Center
2020-2024
UCLA Medical Center
2020-2024
Torrance Memorial Medical Center
2022
University of Pisa
2022
The Lundquist Institute
2020-2021
Center for Rheumatology
2020-2021
Coronary artery disease (CAD), the most common manifestation of cardiovascular disease, remains cause mortality in United States. Risk assessment is key for primary prevention coronary events and calcium (CAC) scoring using computed tomography (CT) one such non-invasive tool. Despite proven clinical value CAC, current practice implementation CAC has limitations as lack insurance coverage test, need capital-intensive CT machines, specialized imaging protocols, accredited 3D labs analysis...
Abstract Objective Damage to the vascular endothelium is strongly implicated in pathogenesis of idiopathic inflammatory myopathies (IIM). Normally, high-density lipoprotein (HDL) protects from damage oxidized phospholipids, which accumulate under conditions oxidative stress. The current work evaluated antioxidant function HDL IIM patients. Methods HDL’s was measured patients using a cell-free assay, assesses ability isolated patient inhibit oxidation low-density lipoproteins and reported as...
Abstract Background Statins are the most widely used lipid lowering therapies which reduce cardiovascular risk, but associated with muscular adverse events (AEs). Idiopathic inflammatory myopathies (IIM) autoimmune diseases of muscle higher risk disease. More data is needed regarding statin safety in patients intrinsic disease such as IIM. Hypothesis tolerated IIM without leading to significant increase AEs. Methods Statin use was retrospectively examined a longitudinal cohort. Safety...
Blue zones are longevity hotspots around the world characterized by highest concentrations of healthy centenarians. Certified blue zone communities designed implementation environmental and policy changes that promote behaviors.To examine trends prevalence zero CAC, a marker ideal cardiovascular overall health status burden risk factors in Beach Cities/certified Southern California rest California.This is population-based cohort study persons aged 50 years or older California, who underwent...
Background: Residual cardiovascular (CV) risk persists despite statin therapy. In REDUCE-IT, icosapent ethyl (IPE) reduced total CV events by 30%, but the mechanisms of benefit are not fully understood. The EVAPORATE trial evaluated effects IPE as adjunct to statins on adverse atherosclerotic plaque characteristics CCTA. Here we use a novel software validated using histology evaluate effect vulnerable features. Methods: randomized statin-treated patients, with high TG (135-499 mg/dL), and...
Patients with idiopathic inflammatory myopathies (IIM) have severe vascular involvement, which contributes to disease morbidity and mortality. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated protein that protects the endothelium from oxidative injury damage. The current work assessed functional genetic determinants of PON1 activity in IIM patients.
Arterial stiffness expressed by cardio-ankle vascular index (CAVI) is a marker of arteriosclerosis. It can increase load, which in turn may affect the viscoelastic myocardial properties and left ventricular compliance. In present study, we sought to investigate association between CAVI structure assessed cardiac computed tomography (CT) multiethnic adult cohort.CAVI was measured using screening system VaSera VS-1500 AU (Fukuda Denshi, Japan). The average right values utilized for analysis....
Golub, Ilana; Benzing, Travis; Kianoush, Sina; Krishnan, Srikanth; Ichikawa, Keishi; Budoff, Matthew J. Author Information
Background: Aortic arch calcium (AAC), which is frequently detected on ungated lung computed tomography (CT) due to a large field of view, can serve as marker subclinical atherosclerotic burden. Our study sought validate novel cardiac screening metrics atherosclerosis by evaluating the inter- and intra- observer reproducibility AAC measurements with CT.Methods: The authors randomly selected 100 CT scans from Multi-Ethnic Study Atherosclerosis cohort. A Bland-Altman plot analysis was used...
Background: Despite the beneficial effects of statins on progression coronary atherosclerosis and cardiovascular (CV) events, significant CV risk persists in patients with hypertriglyceridemia. In REDUCE-IT (Reduction Cardiovascular Events Icosapent Ethyl-Intervention Trial), icosapent ethyl (IPE) added to reduced initial total events by 25% 30%, but mechanisms benefit are unclear. a follow-up analysis, degree from IPE was predominantly related achieved serum EPA levels. Methods: EVAPORATE...