A5047252742- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Hormonal Regulation and Hypertension
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Angiogenesis and VEGF in Cancer
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Sodium Intake and Health
- Cancer Treatment and Pharmacology
- Abdominal vascular conditions and treatments
- Peripheral Nerve Disorders
- Receptor Mechanisms and Signaling
- Hemodynamic Monitoring and Therapy
- Sexual function and dysfunction studies
St. John's Hospital
2013-2024
Prairie Vascular Institute
2008-2022
Prairie Education and Research Cooperative
2000-2017
SRH Klinikum Karlsbad-Langensteinbach
2017
St. John's University
2002-2015
Massachusetts General Hospital
2015
Southern Illinois University School of Medicine
1997-2014
GTx (United States)
2014
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2014
Universitätsklinikum des Saarlandes
2014
Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension.We designed a prospective, single-blind, randomized, sham-controlled trial. Patients severe hypertension were randomly assigned 2:1 ratio to undergo renal or sham procedure. Before randomization, receiving stable antihypertensive regimen involving maximally tolerated doses of at least three drugs, including diuretic. The primary efficacy end point...
The treatment of peripheral artery disease with percutaneous transluminal angioplasty is limited by the occurrence vessel recoil and restenosis. Drug-coated balloons deliver antiproliferative agents directly to artery, potentially improving patency reducing restenosis.In this single-blind, randomized trial conducted at 54 sites, we assigned, in a 2:1 ratio, 476 patients symptomatic intermittent claudication or ischemic pain while rest angiographically significant atherosclerotic lesions...
The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior RDN studies have demonstrated significant and durable reductions in blood pressure. This analysis investigated factors that may help explain these disparate results. Patients with resistant hypertension were randomized 2 : 1 to (n = 364) or sham 171). endpoint was difference office systolic pressure (SBP) change at 6 months. A...
Hypertension represents a significant global public health concern, contributing to vascular and renal morbidity, cardiovascular mortality, economic burden. The opportunity influence clinical outcomes through hypertension management is therefore paramount. Despite adherence multiple available medical therapies, proportion of patients have persistent blood pressure elevation, condition termed resistant hypertension. Recent recognition the importance sympathetic somatic nerves in modulating...
The aim of this study was to assess the safety and effectiveness directional atherectomy (DA) for endovascular treatment peripheral arterial disease (PAD) in infrainguinal arteries patients with claudication or critical limb ischemia.To date, no prospective, multicenter, independently-adjudicated has evaluated durability DA PAD. Previous studies have not been prospectively powered evaluate any differences outcomes without diabetes.DEFINITIVE LE (Determination EFfectiveness SilverHawk(®)...
Background— Studies assessing drug-coated balloons (DCB) for the treatment of femoropopliteal artery disease are encouraging. However, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone. Vessel preparation directional atherectomy (DA) potentially improves outcomes DCB. Methods and Results— DEFINITIVE AR study (Directional Atherectomy Followed by a Paclitaxel-Coated Balloon Inhibit Restenosis Maintain Patency—A Pilot Study Anti-Restenosis Treatment) was...
Background —Animal models of therapeutic angiogenesis have stimulated development clinical application in patients with limited options for coronary revascularization. The impact recombinant human vascular endothelial growth factor (rhVEGF) on myocardial perfusion humans has not been reported. Methods and Results —Fourteen underwent exercise (n=11), dobutamine (n=2), or dipyridamole (n=1) single photon emission CT (SPECT) before as well 30 60 days after rhVEGF administration. After uniform...
This analysis proposes safety and performance goals for prospective single-arm trials of bare nitinol stents to treat patients with debilitating claudication associated femoropopliteal (FP) atherosclerotic lesions.To date there have been no analyses clinical data set efficacy benchmarks new in the treatment from FP disease. Industry has reluctant sponsor studies due logistical barriers.VIVA Physician's, Inc. (VPI) analyzed subject-level PTA control arm three randomized FDA device conducted...
Background— Preservation of renal function is an important objective artery stent procedures. Although atheroembolization can cause dysfunction during procedures, whether adjunctive use embolic protection devices or glycoprotein IIb/IIIa inhibitors improves unknown. Methods and Results— One hundred patients undergoing stenting at 7 centers were randomly assigned to open-label device, Angioguard, double-blind a platelet inhibitor, abciximab, in 2×2 factorial design. The main effects...
Angioplasty and stenting are options for revascularization of symptomatic femoral popliteal disease. Although angioplasty alone is effective in short lesions, longer lesions often treated with stents. Multiple overlapping stents expensive may be associated stent fracture. This trial evaluated the safety efficacy a single self-expanding up to 20 cm length patients atherosclerotic disease superficial artery (SFA) proximal artery.Patients >4 <18 were enrolled this nonrandomized, prospective,...
Abstract Background Drug coated balloon (DCB) angioplasty significantly reduces reintervention rates in patients with symptomatic femoropopliteal peripheral artery disease (PAD). However, stand‐alone DCB use long, severely calcified lesions is frequently associated vessel recoil and/or high‐grade dissections necessitating provisional stent implantation. Objectives Assess the safety and effectiveness of a preparation strategy directional atherectomy (DA) prior to PAD. Methods REALITY (...